研究领域
健康与遗传心理学 精神疾患遗传信息工具平台的开发 健康与遗传心理学 精神疾患发生发展过程中基因环境交互作用的机制 健康与遗传心理学 基因表达调控网络在精神疾患中的作用机制研究
研究经历：
1．人类全基因组范围内变异位点调控功能分析
2．慢性应激环境下基因表达调控网络的构建与分析。
3．重度抑郁症多层次知识库的构建与开发。
4．GWAS分析平台ICSNPathway生物学意义阐述。
5．淋巴细胞阿片类受体功能研究。
6．猴免疫缺陷病毒Nef蛋白功能研究。
研究兴趣：
1. 精神神经疾病遗传信息工具平台的开发；
2. 精神神经疾病发生发展过程中基因环境交互作用的机制；
3. 基因表达调控网络在精神神经中的作用机制研究。
近期论文
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1. Guo, L.Y*., Jin, B*., Zhang, Y.D. and Wang, J#. (2020) Identification of a missense ARSA mutation in metachromatic leukodystrophy and its potential pathogenic mechanism. Mol Genet Genom Med.
2. Guo, L.Y.*, Lin, W., Zhang, Y.D. and Wang, J#. (2020) A Systematic Analysis Revealed the Potential Gene Regulatory Processes of ATRA-Triggered Neuroblastoma Differentiation and Identified a Novel RA Response Sequence in the NTRK2 Gene. Biomed Res Int, 2020.
3. Wu, M.S*., Fang, K.C*., Wang, W.X., Lin, W., Guo, L.Y.# and Wang, J#. (2019) Identification of key genes and pathways for Alzheimer’s disease via combined analysis of genome-wide expression profiling in the hippocampus. Biophysics Reports.
4. Guo, L.Y.*, Lin, W., Zhang, Y.D., Li, W.H. and Wang, J#. (2019) BEST: a web server for brain expression Spatio-temporal pattern analysis. Bmc Bioinformatics, 20.
5. Guo, L.Y.*# and Wang, J.*# (2018) rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks. Nucleic Acids Res, 46, D1111-D1116.
6. Qu, S.S*., Du, Y., Chang, S.H., Guo, L.Y., Fang, K.C., Li, Y.Z., Zhang, F.C., Zhang, K.L. and Wang, J#. (2017) Common variants near IKZF1 are associated with primary Sjogren's syndrome in Han Chinese. Plos One, 12.
7. Wang, J.L*., Qu, S.S., Wang, W.X., Guo, L.Y., Zhang, K.L., Chang, S.H#. and Wang, J.# (2016) A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. J Psychiatr Res, 82, 23-29.
8. Guo, L.Y.*, Du, Y.*, Qu, S.S. and Wang, J#. (2016) rVarBase: an updated database for regulatory features of human variants. Nucleic Acids Res, 44, D888-D893.
9. Zhang, K.L., Chang, S.H., Guo, L.Y. and Wang, J#. (2015) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Protein Cell, 6, 221-224.
10. Guo, L.Y.*#, Du, Y. and Wang, J#. (2015) Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research. Sci Rep-Uk, 5.
11. Guo, L.Y.*, Du, Y., Chang, S.H., Zhang, W.N. and Wang, J#. (2014) Applying Differentially Expressed Genes From Rodent Models of Chronic Stress to Research of Stress-Related Disease: An Online Database. Psychosom Med, 76, 644-649.
12. Guo, L.Y.*, Du, Y.*, Chang, S.H., Zhang, K.L. and Wang, J.# (2014) rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Res, 42, D1033-D1039.
13. Zhang, W.N.*, Chang, S.H., Guo, L.Y., Zhang, K.L. and Wang, J#. (2013) The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies. J Affect Disorders, 151, 531-539.
14. Guo, L.Y.*, Zhang, W.N.*, Chang, S.H.*, Zhang, L.Y., Ott, J. and Wang, J# (2012) MK4MDD: A Multi-Level Knowledge Base and Analysis Platform for Major Depressive Disorder. Plos One, 7.
15. Zhang, K.L., Chang, S.H., Cui, S.J., Guo, L.Y., Zhang, L.Y. and Wang, J.# (2011) ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res, 39, W437-W443.
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