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招生方向:生态毒理学具有分子生物学,细胞生物学,生物化学,环境科学等专业背景的考生均可报考。 研究内容 系统生物学和海洋生态毒理学 2005年毕业于中国科学院长春应用化学研究所,获理学博士学位。2005年至2009年先后在英国伯明翰大学生物系,香港科技大学生物系从事系统生物学和海洋生态毒理学博士后研究。2009年到中国科学院烟台海岸带研究所工作。主要研究领域为系统生物学和海洋生态毒理学。目前主持的主要项目有国家自然科学基金、国家重点基础研究发展计划(子课题)等。已发表SCI论文100余篇,他引3000余次,h指数为32。2017年,入选中科院“特聘”研究员,2018年入选享受国务院“政府特殊津贴”专家。 目前共培养研究生22名。培养的研究生中,获得“中国科学院院长特别奖”1人次、“中国科学院院长优秀奖”1人次、“中国科学院大学-澳大利亚必和必拓”奖学金1人次、“刘瑞玉海洋科学奖”2人次、中科环保奖学金1人次、国家奖学金3人次、中国科学院百篇优秀博士论文1人次。吴惠丰研究员本人获2012年度“中国科学院大学-澳大利亚必和必拓”导师科研奖、2013年度“中国科学院优秀导师奖”、2014年度“中国科学院优秀指导教师奖”。

研究领域

系统生物学和海洋生态毒理学

近期论文

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[1] Ji, Chenglong.,Lu, Zhen.,Xu, Lanlan.,Li, Fei.,Cong, Ming.,...&Wu, Huifeng.(2020).Global responses to tris(1-chloro-2-propyl)phosphate (TCPP) in rockfish Sebastes schlegeli using integrated proteomic and metabolomic approach.SCIENCE OF THE TOTAL ENVIRONMENT,724. [2] 孟祥敬,李斐,王晓晴,等. 石墨烯联合磷酸三苯酯(TPP)胁迫紫贻贝(Mytilus galloprovincialis)的生理生化响应[J]. 科学通报,2020,65(16):1599-1609. [3] Yu, Deliang.,Wu, Huifeng.,Peng, Xiao.,Ji, Chenglong.,Zhang, Xiaoying.,...&Qu, Junle.(2020).Profiling of microRNAs and mRNAs in marine mussel Mytilus galloprovincialis.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,230,108697. [4] Lu, Z,Huang, WQ,Wang, S,Shan, XJ,Ji, CL,&Wu, HF.(2020).Liver transcriptome analysis reveals the molecular responses to low-salinity in large yellow croaker Larimichthys crocea.AQUACULTURE,517,UNSP 734827. [5] Sun, Tao,Wu, Huifeng,Cong, Ming,Zhan, Junfei,&Li, Fei.(2020).Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans.AGING-US,12(3),2723-2746. [6] Meng, Xiangjing,Li, Fei,Wang, Xiaoqing,Liu, Jialin,Ji, Chenglong,&Wu, Huifeng.(2020).Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate.MARINE POLLUTION BULLETIN,151,110838. [7] Lu, Z.,Wang, S.,Ji, CL.,Li, F.,Cong, M.,...&Wu, HF.(2020).iTRAQ-based proteomic analysis on the mitochondrial responses in gill tissues of juvenile olive flounder Paralichthys olivaceus exposed to cadmium.ENVIRONMENTAL POLLUTION,257,113591. [8] Zhou, Di.,Yu, Junbao.,Guan, Bo.,Li, Yunzhao.,Yu, Miao.,...&Yang, Jisong.(2020).A Comparison of the Development of Wetland Restoration Techniques in China and Other Nations.WETLANDS. [9] Lu, Z,Wang, S,Ji, CL,Shan, XJ,&Wu, HF.(2020).Evaluation of metal pollution-induced biological effects in Chinese shrimp Fenneropenaeus chinensis by NMR-based metabolomics.MARINE POLLUTION BULLETIN,150,110688. [10] Xu, LL.,Lu, Z.,Ji, CL.,Cong, M.,Li, F.,...&Wu, HF.(2019).Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach.ENVIRONMENTAL POLLUTION,255(2),113333. [11] Meng, XJ,Li, F,Wang, XQ,Liu, JL,Ji, CL,&Wu, HF.(2019).Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,378,UNSP 120778. [12] Lv, JS,Zhao, JM,Yang, DL,Wu, HF,&Cong, M.(2019).Tissue distribution and functional characterization of mytimacin-4 in Mytilus galloprovincialis.JOURNAL OF INVERTEBRATE PATHOLOGY,166,107215. [13] Ji, CL.,Lu, Z.,Xu, LL.,Li, F.,Cong, M.,...&Wu, HF.(2019).Evaluation of mitochondrial toxicity of cadmium in clam Ruditapes philippinarum using iTRAQ-based proteomics.ENVIRONMENTAL POLLUTION,251,802-810. [14] Wang, XQ,Meng, XJ,Li, F,Ding, JW,Ji, CL,&Wu, HF.(2019).The critical factors affecting typical organophosphate flame retardants to mimetic biomembrane: An integrated in vitro and in silico study.CHEMOSPHERE,226,159-165. [15] Lu, Z,Shan, XJ,Ji, CL,Zhao, JM,&Wu, HF.(2019).Proteomic responses induced by metal pollutions in oysters Crassostrea sikamea.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(2),685-693. [16] Liu, Feng,Lu, Zhen,Wu, Huifeng,&Ji, Chenglong.(2019).Dose-dependent effects induced by cadmium in polychaete Perinereis aibuhitensis.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,169,714-721. [17] Lu, Zhen,Wang, Shuang,Shan, Xiujuan,Ji, Chenglong,&Wu, Huifeng.(2019).Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,65,66-72. [18] Cong, Ming,Wu, Huifeng,Cao, Tengfei,Ji, Chenglong,&Lv, Jiasen.(2019).Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,65,46-52. [19] 王晓晴,刘佳琳,李斐,等. 磷酸三苯酯(TPP)和磷酸三(2-氯异丙基)酯(TCPP)诱导人胚肾细胞HEK293凋亡的机制研究[J]. 生态毒理学报,2019,14(5):123-132. [20] 李斐,王晓晴,刘佳琳,等. 溴系阻燃剂毒理效应的计算模拟预测与环境风险评估进展[J]. 生态毒理学报,2019,14(4):2-13. [21] 王晓晴,李斐,刘佳琳,等. 评估和预测有机磷酸酯阻燃剂对模拟生物膜损伤的方法. 评估和预测有机磷酸酯阻燃剂对模拟生物膜损伤的方法. 2018-12-21. [22] Chen, Lizhu.,Wu, Huifeng.,Zhao, Jianmin.,Zhang, Wei.,Zhang, Li.,...&Wang, Qing.(2018).The role of GST omega in metabolism and detoxification of arsenic in clam Ruditapes philippinarum.AQUATIC TOXICOLOGY,204,9-18. [23] Yang, Dinglong.,Zhang, Qianqian.,Wang, Qing.,Chen, Lizhu.,Liu, Yongliang.,...&Zhao, Jianmin.(2018).A defensin-like antimicrobial peptide from the manila clam Ruditapes philippinarum: Investigation of the antibacterial activities and mode of action.FISH & SHELLFISH IMMUNOLOGY,80,274-280. [24] Wu, Huifeng.,Zhong, Mingyu.,Lu, Zhen.,Shan, Xiujuan.,Li, Fei.,...&Cong, Ming.(2018).Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,61,102-106. [25] Cao, Ruiwen.,Wang, Qing.,Yang, Dinglong.,Liu, Yongliang.,Ran, Wen.,...&Zhao, Jianmin.(2018).CO2-induced ocean acidification impairs the immune function of the Pacific oyster against Vibrio splendidus challenge: An integrated study from a cellular and proteomic perspective.SCIENCE OF THE TOTAL ENVIRONMENT,625,1574-1583. [26] Zhong, Mingyu.,Wu, Huifeng.,Mi, Wenying.,Li, Fei.,Ji, Chenglong.,...&Tang, Jianhui.(2018).Occurrences and distribution characteristics of organophosphate ester flame retardants and plasticizers in the sediments of the Bohai and Yellow Seas, China.SCIENCE OF THE TOTAL ENVIRONMENT,615(0),1305-1311. 浏览/下载:529/150; 被引[WOS]:45; IF:6.551/6.419 评论推荐收藏 [27] Cong, Ming.,Wu, Huifeng.,Cao, Tengfei.,Lv, Jiasen.,Wang, Qing.,...&Zhao, Jianmin.(2018).Digital gene expression analysis in the gills of Ruditapes philippinarum exposed to short- and long-term exposures of ammonia nitrogen.AQUATIC TOXICOLOGY,194,121-131. [28] 李斐,丁家旺,吴惠丰,等. 电化学方法研究石墨烯和磷酸三苯酯(TPP)与模拟生物膜间的相互作用[J]. 科学通报,2017,62(36):4285-4293. [29] Li, Fei.,Wang, Li.,Ji, Chenglong.,Wu, Huifeng.,Zhao, Jianmin.,...&Wu, Huifeng.(2017).Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells.CHEMOSPHERE,187,88-96. [30] Xie, Jia.,Yang, Dinglong.,Sun, Xiyan.,Cao, Ruiwen.,Chen, Lizhu.,...&Zhao, Jianmin.(2017).Individual and Combined Toxicities of Benzo[a]pyrene and 2,2',4,4'-Tetrabromodiphenyl Ether on Early Life Stages of the Pacific Oyster, Crassostrea gigas.BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,99(5),582-588. [31] Yu, Qian.,Yang, Dinglong.,Wang, Qing.,Zhang, Yingying.,Cong, Ming.,...&Zhao, Jianmin.(2017).Molecular characterization, expression and functional analysis of two Kazal-type serine protease inhibitors from Venerupis philippinarum.FISH & SHELLFISH IMMUNOLOGY,70,156-163. [32] Xie, J.,Yang, DL.,Sun, XY.,Cao, RW.,Chen, LZ.,...&Zhao, JM.(2017).Individual and Combined Toxicities of Benzo[a]pyrene and 2,2',4,4'-Tetrabromodiphenyl Ether on Early Life Stages of the Pacific Oyster, Crassostrea gigas.BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,99(5),582-588. [33] 刘佳琳,徐兰兰,路珍,等. 基于核磁共振的褐牙鲆幼鱼组织代谢组学分析[J]. 海洋通报,2017,36(5):538-546. [34] Zhong, Mingyu.,Tang, Jianhui.,Mi, Lijie.,Li, Fei.,Wang, Runmei.,...&Tang, Jianhui.(2017).Occurrence and spatial distribution of organophosphorus flame retardants and plasticizers in the Bohai and Yellow Seas, China.MARINE POLLUTION BULLETIN,121(1-2),331-338. [35] Yang, Dinglong.,Wang, Qing.,Cao, Ruiwen.,Chen, Lizhu.,Liu, Yongliang.,...&Zhao, Jianmin.(2017).Molecular characterization, expression and antimicrobial activities of two c-type lysozymes from manila clam Venerupis philippinarum.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,73,109-118. [36] 陈丽竹,王丹,曹瑞文,等. 菲律宾蛤仔对三价和五价无机砷的富集转化规律[J]. 海洋通报,2017,36(3):326-332. [37] 吴惠丰,张明兴,李斐,等. 石墨烯与抑癌基因p53 DNA片段相互作用的分子模拟与光谱学验证[J]. 生态毒理学报,2017,12(3):243-250. [38] Yang, Dinglong.,Wang, Qing.,Chen, Lizhu.,Liu, Yongliang.,Cao, Ruiwen.,...&Zhao, Jianmin.(2017).Molecular characterization and antibacterial activity of a phage-type lysozyme from the Manila clam, Ruditapes philippinarum.FISH & SHELLFISH IMMUNOLOGY,65,17-24. [39] 谢嘉,滕佳,刘永亮,等. Cd~(2+)和Pb~(2+)单一与复合污染对脊尾白虾的急性毒性效应研究[J]. 海洋科学,2017,41(5):27-33. [40] Cong, Ming,Wu, Huifeng,Yang, Haiping,Zhao, Jianmin,Lv, Jiasen,&Wu, HF.(2017).Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum.ECOTOXICOLOGY,26(3),459-469. [41] Wu, Huifeng.,Liu, Jialin.,Lu, Zhen.,Xu, Lanlan.,Ji, Chenglong.,...&Wu, HF .(2017).Metabolite and gene expression responses in juvenile flounder Paralichthys olivaceus exposed to reduced salinities.FISH & SHELLFISH IMMUNOLOGY,63,417-423. [42] Zhang, Ying,Wu, Huifeng,Wei, Lei,Xie, Zeping,Guan, Bo,&Zhang, Y .(2017).Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics.MARINE POLLUTION BULLETIN,114(1),84-89. [43] Wu, Huifeng,Xu, Lanlan,Yu, Deliang,Ji, Chenglong,&Wu, HF .(2017).Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium.ECOTOXICOLOGY,26(1),74-80. [44] Xu, Lanlan,Ji, Chenglong,Zhao, Jianmin,Wu, Huifeng,&Wu, HF .(2016).Metabolic responses to metal pollution in shrimp Crangon affinis from the sites along the Laizhou Bay in the Bohai Sea.MARINE POLLUTION BULLETIN,113(1-2),536-541. 浏览/下载:231/70; 被引[WOS]:7; IF:4.049/4.407 评论推荐收藏 [45] Xie, Jia.,Zhao, Yun.,Wang, Qing.,Wu, Huifeng.,Teng, Jia.,...&Zhao, JM .(2016).An integrative biomarker approach to assess the environmental stress in the north coast of Shandong Peninsula using native oysters, Crassostrea gigas (vol 112, pg 318, 2016).MARINE POLLUTION BULLETIN,113(1-2),600-600. [46] Wu, Huifeng,Xu, Lanlan,Ji, Chenglong,Yu, Deliang,&Wu, HF .(2016).Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic.FISH & SHELLFISH IMMUNOLOGY,58,514-520. [47] Cong, M,Zhao, JM,Lu, JS,Ren, ZM,Wu, HF,&Wu, HF .(2016).Homologous cloning, characterization and expression of a new halophyte phytochelatin synthase gene in Suaeda salsa.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(5),1034-1043. 浏览/下载:197/68; 被引[WOS]:3; IF:1.068/0.983 评论推荐收藏 [48] Zheng, X,Zhao, YR,Wu, HF,Dong, JY,Feng, JH,&Feng, JH .(2016).Origin Identification and Quantitative Analysis of Honeys by Nuclear Magnetic Resonance and Chemometric Techniques.FOOD ANALYTICAL METHODS,9(6),1470-1479. [49] Ji, CL.,Yu, DL.,Wang, Q.,Li, F.,Zhao, JM.,...&Wu, HF .(2016).Impact of metal pollution on shrimp Crangon affinis by NMR-based metabolomics.MARINE POLLUTION BULLETIN,106(1-2),372-376. [50] Yu, DL,Ji, CL,Zhao, JM,Wu, HF,&Wu, HF .(2016).Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis.CHEMOSPHERE,150,194-201. [51] Shen, GP,Li, ZS,Zhang, Y,Wu, HF,Feng, JH,&Feng, JH .(2016).H-1 NMR-based metabolomics study on the physiological variations during the rat pregnancy process.MOLECULAR AND CELLULAR ENDOCRINOLOGY,423(C),40-50. [52] Ji, CL.,Li, F.,Wang, Q.,Zhao, JM.,Sun, ZD.,...&Wu, HF .(2016).An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA).CHEMOSPHERE,144,527-539. [53] Wang, Q.,Cao, RW.,Ning, XX.,You, LP.,Mu, CK.,...&Zhao, JM .(2016).Effects of ocean acidification on immune responses of the Pacific oyster Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,49,24-33. [54] Ji, CL,Wang, Q,Wu, HF,Tan, QG,Wang, WX,&Wu, HF .(2016).A metabolomic study on the biological effects of metal pollutions in oysters Crassostrea sikamea.MARINE POLLUTION BULLETIN,102(1),216-222. [55] 于倩,王清,韩伟,等. 具槽帕拉藻代谢组提取方法的比较研究[J]. 海洋通报,2015,34(6):703-709. [56] 于倩,王清,袁泽轶,等. 不同形态磷源对具槽帕拉藻(Paralia sulcata)生长和磷酸酶活性的影响[J]. 海洋与湖沼,2015,46(5):1018-1023. [57] 丛明,杨海萍,赵建民,等. 一种综合评价氨态氮对水生动物威胁的方法. 2015-08-21. [58] 吴惠丰,曹璐璐,李斐,等. 典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证[J]. 科学通报,2015,60(19):1804-1809. [59] Yu, Junbao.,Lv, Xiaofei.,Bin, Ma.,Wu, Huifeng.,Du, Siyao.,...&Han, Guangxuan.(2015).Fractal features of soil particle size distribution in newly formed wetlands in the Yellow River Delta.SCIENTIFIC REPORTS,5. [60] Li, Zhishui.,Lin, Chenghong.,Xu, Jingjing.,Wu, Huifeng.,Feng, Jianghua.,...&Feng, JH .(2015).The relations between metabolic variations and genetic evolution of different species.ANALYTICAL BIOCHEMISTRY,477,105-114. [61] Wu, Huifeng,Cao, Lulu,Li, Fei,Lian, Peiwen,Zhao, Jianmin,&Li, F .(2015).Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells.CHEMOSPHERE,126,32-39. [62] Li Fei,Wu Huifeng,Wang Qing,Li Xuehua,Zhao Jianmin,&Wu, HF .(2015).Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,33(3),705-713. [63] Lyu, Xiaofei.,Yu, Junbao.,Zhou, Mo.,Ma, Bin.,Wang, Guangmei.,...&Yu, JB .(2015).Changes of Soil Particle Size Distribution in Tidal Flats in the Yellow River Delta.PLOS ONE,10(3),e0121368. [64] Wei, Lei.,Wang, Qing.,Ning, Xuanxuan.,Mu, Changkao.,Wang, Chunlin.,...&jmzhao@yic.ac.cn.(2015).Combined metabolome and proteome analysis of the mantle tissue from Pacific oyster Crassostrea gigas exposed to elevated pCO(2).COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,13,16-23. [65] Li, Fei.,Cao, Lulu.,Li, Xuehua.,Li, Na.,Wang, Zijian.,...&Wu, HF .(2015).Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study.TOXICOLOGY LETTERS,232(2),533-541. [66] Ji, Chenglong,Wang, Qing,Wu, Huifeng,Tan, Qiaoguo,Wang, Wen-Xiong,&Wu, HF .(2015).A metabolomic investigation of the effects of metal pollution in oysters Crassostrea hongkongensis.MARINE POLLUTION BULLETIN,90(1-2),317-322. [67] Qu, Fanzhu.,Yu, Junbao.,Du, Siyao.,Li, Yunzhao.,Lv, Xiaofei.,...&Yu, JB .(2014).Influences of anthropogenic cultivation on C, N and P stoichiometry of reed-dominated coastal wetlands in the Yellow River Delta.GEODERMA,235,227-232. [68] Ji, Chenglong,Wu, Huifeng,Wei, Lei,Zhao, Jianmin,&Wu, HF .(2014).iTRAQ-based quantitative proteomic analyses on the gender-specific responses in mussel Mytilus galloprovincialis to tetrabromobisphenol A.AQUATIC TOXICOLOGY,157,30-40. [69] Li, Fei.,Yang, Xianhai.,Li, Xuehua.,Li, Renmin.,Zhao, Jianmin.,...&hfwu@yic.ac.cn.(2014).Determination and Prediction of the Binding Interaction between Organophosphate Flame Retardants and p53.CHEMICAL RESEARCH IN TOXICOLOGY,27(11),1918-1925. 浏览/下载:412/177; 被引[WOS]:6; IF:3.184/3.426 评论推荐收藏 [70] Li, Fei.,Li, Renmin.,Yang, Xianhai.,You, Liping.,Zhao, Jianmin.,...&hfwu@yic.ac.cn.(2014).The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach.MARINE POLLUTION BULLETIN,85(2),516-521. [71] Liu, Xiaoli.,Ji, Chenglong.,Zhao, Jianmin.,Wang, Qing.,Li, Fei.,...&Liu, XL .(2014).Metabolic profiling of the tissue-specific responses in mussel Mytilus galloprovincialis towards Vibrio harveyi challenge.FISH & SHELLFISH IMMUNOLOGY,39(2),372-377. [72] Yu, Junbao.,Li, Yunzhao.,Han, Guangxuan.,Zhou, Di.,Fu, Yuqin.,...&Yu, JB .(2014).The spatial distribution characteristics of soil salinity in coastal zone of the Yellow River Delta.ENVIRONMENTAL EARTH SCIENCES,72(2),589-599. [73] Li, Lianzhen,Wu, Huifeng,van Gestel, Cornelis A. M.,Peijnenburg, Willie J. G. M.,Allen, Herbert E.,&van Gestel, CAM .(2014).Soil acidification increases metal extractability and bioavailability in old orchard soils of Northeast Jiaodong Peninsula in China.ENVIRONMENTAL POLLUTION,188,144-152. [74] Ji, Chenglong,Zhao, Jianmin,Wu, Huifeng,&Wu, HF .(2014).Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,37(3),1116-1122. 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