个人简介
招生专业
070703-海洋生物学
090801-水产养殖
招生方向
免疫学基础及应用
水产养殖生物病害防治
教育背景
1992-09--1999-01 美国波士顿大学 理学博士
1987-09--1990-06 南开大学 理学硕士
1983-09--1987-06 南开大学 理学学士
工作简历
2005-01~现在, 中国科学院海洋研究所, 研究员
1999-02~2003-11,英国牛津大学和美国哈佛大学, 博士后
1992-09~1999-01,美国波士顿大学, 理学博士
1987-09~1990-06,南开大学, 理学硕士
1983-09~1987-06,南开大学, 理学学士
教授课程
海洋生物免疫与病害防控
海水养殖生物病害与防控
微生物与免疫学文献阅读
免疫学
奖励信息
（1） 海水养殖鱼类细菌性疫病的免疫防控, 二等奖, 部委级, 2015
专利成果
（ 1 ） 一种鱼类高迁移率族蛋白及其应用, 2015, 第 1 作者, 专利号: ZL201310480020.9
（ 2 ） 一种含有未甲基化CpG的DNA序列（CpG-DNA）及其应用, 2015, 第 1 作者, 专利号: ZL201310479972.9
（ 3 ） 一种海豚链球菌DNA疫苗及其应用, 2015, 第 1 作者, 专利号: ZL201310557674.7
（ 4 ） 一种海豚链球菌细菌素及其应用, 2015, 第 1 作者, 专利号: ZL201410067698.9
（ 5 ） 一种大菱鲆自然杀伤细胞增强因子表达载体的应用, 2015, 第 1 作者, 专利号: ZL2013102944639
（ 6 ） 一种抗菌肽及其应用, 2015, 第 1 作者, 专利号: ZL2014100676974
（ 7 ） 一种荧光假单胞菌TonB依赖型外膜受体及其应用, 2015, 第 1 作者, 专利号: ZL201410140163X
（ 8 ） 基于大菱鲆铁调素的肽及其应用, 2016, 第 1 作者, 专利号: ZL201410037471.X
（ 9 ） 条石鲷白细胞介素12亚基IL-12p40及其应用, 2016, 第 1 作者, 专利号: ZL201410140353.1
科研项目
（ 1 ） 病毒和细菌共诱导的多效型牙鲆microRNA及其功能解析和应用探索, 主持, 国家级, 2018-01--2022-12
（ 2 ） 水产动物疫病发生的分子基础与免疫机制, 主持, 国家级, 2018-12--2022-12
（ 3 ） 深海极端环境微生物资源的挖掘和生物安保探索, 主持, 部委级, 2019-01--2022-12
（ 4 ） 山东省重大科技创新工程专项项目“深蓝渔业生物学基础与前沿关键技术研发”, 主持, 省级, 2018-07--2020-12
近期论文
查看导师最新文章
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（1） Japanese flounder pol-miR-3p-2 suppresses Edwardsiella tarda infection by regulation of autophagy via p53, Dev Comp Immunol., 2020, 通讯作者
（2） Gene network analysis reveals a core set of genes involved in the immune response of Japanese flounder (Paralichthys olivaceus) against Vibrio anguillarum infection., Fish Shellfish Immunol., 2020, 通讯作者
（3） Characterization of Streptococcus iniae-induced microRNA profiles in Paralichthys olivaceus and identification of pol-3p-10740_175 as a regulator of antibacterial immune response., Fish Shellfish Immunol., 2020, 通讯作者
（4） The novel fish miRNA pol-miR-novel_171 and its target gene FAM49B play a critical role in apoptosis and bacterial infection., Dev Comp Immunol., 2020, 通讯作者
（5） pol-miR-7133 and pol-miR-3p-9227 of Japanese flounder Paralichthys olivaceus modulate Streptococcus iniae infection through regulation of the common target gene LAMP2., Aquaculture, 2020, 通讯作者
（6） Japanese flounder (Paralichthys olivaceus) Bmal1 is involved in the regulation of inflammatory response and bacterial infection, Aquaculture, 2020, 通讯作者
（7） Japanese flounder Paralichthys olivaceus interleukin 21 induces inflammatory response and plays a vital role in the immune defense against bacterial pathogen., Fish Shellfish Immunol., 2020, 通讯作者
（8） Particle and bacteria uptake by Japanese flounder (Paralichthys olivaceus) red blood cells: size dependence and pathway specificity, Tissue Cell., 2019, 通讯作者
（9） Teleost gasdermin E is cleaved by caspase 1, 3 and 7 and induces pyroptosis., J Immunol, 2019, 通讯作者
（10） Characterization of the genome feature and toxic capacity of a Bacillus wiedmannii isolate from the hydrothermal field in Okinawa Trough, Front Cell Infect Microbiol., 2019, 通讯作者
（11） A first study of the virulence potential of a Bacillus subtilis isolate from deep-sea hydrothermal vent, Front Cell Infect Microbiol., 2019, 通讯作者
（12） Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossus semilaevis) spleen identifies cellular processes essential to viral infection, Dev Comp Immunol, 2019, 通讯作者
（13） pol-miR-194a of Japanese flounder (Paralichthys olivaceus) suppresses type I interferon response and facilitates Edwardsiella tarda infection, Fish Shellfish Immunol., 2019, 通讯作者
（14） A comparative analysis of Edwardsiella tarda-induced transcriptome profiles in RAW264.7 cells reveals new insights into the strategy of bacterial immune evasion, Int J Mol Sci., 2019, 通讯作者
（15） Histones and chymotrypsin-like elastases play significant roles in the antimicrobial activity of tongue sole neutrophil extracellular traps., Fish Shellfish Immunol, 2018, 通讯作者
（16） Internalization of large particles by turbot (Scophthalmus maximus) IgM+ B cells mainly depends on macropinocytosis., Dev Comp Immunol, 2018, 通讯作者
（17） Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin, archives of microbiology, 2018, 通讯作者
（18） First characterization of two C-type lectins of the tubeworm Alaysia sp. from a deep-sea hydrothermal vent., Dev Comp Immunol, 2018, 通讯作者
（19） Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin, archives of microbiology, 2018, 通讯作者
（20） Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection., Dev Comp Immunol, 2018, 通讯作者
（21） Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin, archives of microbiology, 2018, 通讯作者
（22） Edwardsiella tarda Sip2: A serum-induced protein that is essential to serum survival, acid resistance, intracellular replication, and host infection, Front Microbiol, 2018, 通讯作者
（23） Comparative metagenomic analysis of the microbial communities in the surroundings of Iheya north and Iheya ridge hydrothermal fields reveals insights into the survival strategy of microorganisms in deep-sea environments, J Mar Syst, 2018, 通讯作者
（24） Bacterial communities associated with Shinkaia crosnieri from the Iheya North, Okinawa Trough: microbial diversity and metabolic potentials, J Mar Syst, 2018, 通讯作者
（25） Transcriptome analysis reveals temperature-regulated antiviral response in turbot Scophthalmus maximus, Fish & Shellfish Immunology, 2017, 通讯作者
（26） First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes, Veterinary Immunology and Immunopathology, 2017, 通讯作者
（27） A comparative study revealed first insights into the diversity and metabolisms of the microbial communities in the sediments of Pacmanus and Desmos hydrothermal fields, PLOS ONE, 2017, 通讯作者
（28） Comparative transcriptome analysis of Rimicaris sp. reveals novel molecular features associated with survival in deep-sea hydrothermal vent, Scientific Reports, 2017, 通讯作者
（29） A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish, Dev Comp Immunol, 2017, 通讯作者
（30） Neutrophil extracellular traps of Cynoglossus semilaevis: production characteristics and antibacterial effect, Front Immunol., 2017, 通讯作者
（31） Description of Domibacillus iocasensis sp. nov., isolated from the deep sea sediment of Okinawa Trough, and emended description of the genus Domibacillus., Int J Syst Evol Microbiol., 2017, 通讯作者
（32） Shewanella inventionis sp. nov., isolated from deep-sea sediment., Int J Syst Evol Microbiol., 2017, 通讯作者
（33） Comparative metagenomic analysis of the microbial communities in the surroundings of Iheya north and Iheya ridge hydrothermal fields reveals insights into the survival strategy of microorganisms in deep-sea environments., J Mar Syst., 2017, 通讯作者
（34） Description of Algoriphagus iocasae sp. nov., isolated from the deep sea sediment of Okinawa Trough., Int J Syst Evol Microbiol., 2017, 通讯作者
（35） Bacterial communities associated with Shinkaia crosnieri from the Iheya North, Okinawa Trough: microbial diversity and metabolic potentials., J Mar Syst., 2017, 通讯作者
（36） Comparative metagenomics reveals insights into the deep-sea adaptation mechanism of the microorganisms in Iheya hydrothermal fields., World J Microb Biot., 2017, 通讯作者
（37） A teleost CD46 is involved in the regulation of complement activation and pathogen infection, Sci Rep, 2017, 通讯作者
（38） Edwardsiella tarda-induced miRNAs in a teleost host: global profile and role in bacterial infection as revealed by integrative miRNA–mRNA analysis, Virulence, 2017, 通讯作者
（39） Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis, International Journal of Molecular Sciences, 2017, 通讯作者
（40） Intracellular Trafficking Pathways of Edwardsiella tarda: From Clathrinand Caveolin-Mediated Endocytosis to Endosome and Lysosome, Frontiers in Cellular and Infection Microbiology, 2017, 通讯作者
（41） Bacillus iocasae sp. nov., isolated from Pacmanus hydrothermal field, Manus Basin, International Journal of Systematic and Evolutionary Microbiology, 2017, 通讯作者
（42） A teleost bactericidal permeability-increasing protein kills Gram-negative bacteria, modulates innate immune response, and enhances resistance against bacterial and viral infection., PLoS ONE, 2016, 通讯作者
（43） Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: Signaling pathway and involvement in bacterial infection., Fish Shellfish Immunol., 2016, 通讯作者
（44） pol-miR-731, a teleost miRNA upregulated by megalocytivirus, negatively regulates virus-induced type I interferon response, apoptosis, and cell cycle arrest., Sci Rep., 2016, 通讯作者
（45） First comparative analysis of the community structures and carbon metabolic pathways of the bacteria associated with Alvinocaris longirostris in a hydrothermal vent of Okinawa Trough., PLoS ONE, 2016, 通讯作者
（46） The global regulatory effect of Edwardsiella tarda Fur on iron acquisition, stress resistance, and host infection: a proteomics-based interpretation., J Proteomics, 2016, 通讯作者
（47） The serine protease autotransporter Tsh contributes to the virulence of Edwardsiella tarda, Vet Microbiol., 2016, 通讯作者
（48） Description of Domibacillus iocasensis sp. nov., isolated from the deep sea sediment of Okinawa Trough, and emended description of the genus Domibacillus., Int J Syst Evol Microbiol., 2016, 通讯作者
（49） Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection., Dev Comp Immunol., 2016, 通讯作者
（50） Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria., Dev Comp Immunol., 2016, 通讯作者
（51） CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection., Dev Comp Immunol., 2016, 通讯作者
（52） Immune effects of R848: evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-？B-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus)., Dev Comp Immunol , 2015, 通讯作者
（53） CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif., Dev Comp Immunol , 2015, 通讯作者
（54） CD83 is required for the induction of protective immunity by a DNA vaccine in a teleost model, Dev Comp Immunol , 2015, 通讯作者
（55） Edwardsiella tarda evades serum killing by preventing complement activation via the alternative pathway, Fish Shellfish Immunol , 2015, 通讯作者
（56） Pseudomonas fluorescens: Fur is required for multiple biological properties associated with pathogenesis, Vet Microbiol, 2015, 通讯作者
（57） Edwardsiella tarda Sip1: A serum-induced zinc metalloprotease that is essential to serum resistance and host infection., Vet Microbiol , 2015, 通讯作者
（58） Edwardsiella tarda MliC: a lysozyme inhibitor that participates in pathogenesis in a manner that parallels Ivy, Infect Immun, 2015, 通讯作者
（59） Pseudomonas fluorescens: iron-responsive proteins and their involvement in host infection., Vet Microbiol , 2015, 通讯作者
（60） P247 and P523: two in vivo-expressed megalocytivirus proteins that induce protective immunity and are essential to viral infection, Plos ONE, 2015, 通讯作者
（61） Edwardsiella tarda-regulated proteins in Japanese flounder (Paralichthys olivaceus): identification and evaluation of antibacterial potentials, J Proteomics, 2015, 通讯作者
（62） Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection, Dev Comp Immunol, 2014, 通讯作者
（63） Turbot (Scophthalmus maximus) hepcidin-1 and hepcidin-2 possess antimicrobial activity and promote resistance against bacterial and viral infection, Fish Shellfish Immunol, 2014, 通讯作者
（64） Edwardsiella tarda Hfq: impact on host infection and global protein expression, Vet Res, 2014, 通讯作者
（65） Streptococcus iniae SF1: complete genome sequence, proteomic profile, and immunoprotective antigens., Plos ONE, 2014, 通讯作者
（66） Sil: a Streptococcus iniae bacteriocin with dual role as an antimicrobial and an immunomodulator that inhibits innate immune response and promotes S. iniae infection, Plos ONE, 2014, 通讯作者
（67） In-depth profiling and analysis of host and viral microRNAs in Japanese flounder (Paralichthys olivaceus) infected with megalocytivirus reveal involvement of microRNAs in host-virus interaction in teleost fish, BMC Genomics, 2014, 通讯作者
（68） Nuclear factor 45 of tongue sole (Cynoglossus semilaevis): evidence for functional differentiation between two isoforms in immune defense against viral and bacterial pathogens, Dev Comp Immunol , 2014, 通讯作者
（69） Poly(I:C) induces antiviral immune responses in Japanese flounder (Paralichthys olivaceus) that require TLR3 and MDA5 and is negatively regulated by Myd88, Plos ONE, 2014, 通讯作者
（70） NKLP27: a teleost NK-lysin peptide that modulates immune response, induces degradation of bacterial DNA, and inhibits bacterial and viral infection, Plos ONE , 2014, 通讯作者
（71） C7: a CpG oligodeoxynucleotide that induces protective immune response against megalocytivirus in Japanese flounder (Paralichthys olivaceus) via toll-like receptor 9-mediated signaling pathway, Dev Comp Immunol, 2014, 通讯作者
（72） Antibacterial and antiviral properties of tongue sole (Cynoglossus semilaevis) high mobility group B2 protein are largely independent on the acidic C-terminal domain., Fish Shellfish Immunol, 2014, 通讯作者
（73） Characterization of a c-type lysozyme of Scophthalmus maximus: expression, activity, and antibacterial effect, Fish Shellfish Immunol., 2013, 通讯作者
（74） 3. Chen C, Chi H, Sun B, Sun L. The galectin-3-binding protein of Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis., Dev Comp Immunol, 2013, 通讯作者
（75） Macrophage migration inhibitory factor of Sciaenops ocellatus regulates immune cell trafficking and is involved in pathogen-induced immune response, Dev Comp Immunol, 2013, 通讯作者
（76） The C-reactive protein of tongue sole Cynoglossus semilaevis is an acute phase protein that interacts with bacterial pathogens and stimulates the antibacterial activity of peripheral blood leukocytes., Fish Shellfish Immunol., 2013, 通讯作者
（77） Identification and characterization of a cell surface scavenger receptor cysteine-rich protein of Sciaenops ocellatus: bacterial interaction and its dependence on the conserved structural features of the SRCR domain, Fish Shellfish Immunol., 2013, 通讯作者
（78） Selection of normalization factors for quantitative real time RT-PCR studies in Japanese flounder (Paralichthys olivaceus) and turbot (Scophthalmus maximus) under conditions of viral infection, Vet Immunol Immunopathol., 2013, 通讯作者
（79） Complete genome sequence and transcription profiles of the rock bream iridovirus RBIV-C1., Dis Aquat Org. , 2013, 通讯作者
（80） SmLMWPTP, a teleost low molecular weight protein tyrosine phosphatase, inhibits the immune response of peripheral blood leukocytes in a manner that depends on the conserved P-loop., Dev Comp Immunol. , 2013, 通讯作者
（81） A NK-lysin from Cynoglossus semilaevis enhances antimicrobial defense against bacterial and viral pathogens. , Dev Comp Immunol. , 2013, 通讯作者
（82） Comparative study of four flagellins of Vibrio anguillarum: vaccine potential and adjuvanticity., Fish Shellfish Immunol., 2013, 通讯作者
（83） Overexpression of NF-？B inhibitor alpha in Cynoglossus semilaevis impairs pathogen-induced immune response., DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 通讯作者
（84） A peptidoglycan recognition protein from Sciaenops ocellatus is a zinc amidase and a bactericide with a substrate range limited to Gram-positive bacteria., FISH AND SHELLFISH IMMUNOLOGY, 2012, 通讯作者
（85） CsCXCe1: a novel Cynoglossus semilaevis CXC chemokine that functions as a chemoattractant and an immunomodulator for peripheral blood leukocytes, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 通讯作者
（86） Cynoglossus semilaevis thioredoxin: a reductase and an antioxidant with immunostimulatory property, CELL STRESS AND CHAPERONES, 2012, 通讯作者
（87） Edwardsiella tarda DnaK: expression, activity, and the basis for the construction of a bivalent live vaccine against E. tarda and Streptococcus iniae, FISH AND SHELLFISH IMMUNOLOGY, 2012, 通讯作者
（88） A divalent DNA vaccine based on Sia10 and OmpU induces cross protection against Streptococcus iniae and Vibrio anguillarum in Japanese flounder, FISH AND SHELLFISH IMMUNOLOGY, 2012, 通讯作者
（89） Development and efficacy of an attenuated Vibrio harveyi vaccine candidate with cross protectivity against Vibrio alginolyticus., FISH AND SHELLFISH IMMUNOLOGY, 2012, 通讯作者
（90） Molecular characterization of Cynoglossus semilaevis CD28, FISH AND SHELLFISH IMMUNOLOGY, 2012, 通讯作者
（91） Inv1: an Edwardsiella tarda invasin and a protective immunogen that is required for host infection., FISH AND SHELLFISH IMMUNOLOGY, 2012, 通讯作者
（92） Edwardsiella tarda Eta1: an in vivo-induced antigen that is involved in host infection, INFECTION AND IMMUNITY, 2012, 通讯作者
（93） Construction and evaluation of a live vaccine against Edwardsiella tarda and Vibrio harveyi: laboratory vs mock field trial, Vaccine, 2011, 通讯作者
（94） Edwardsiella tarda DnaJ is a virulence-associated molecular chaperone with immunoprotective potential, Fish and Shellfish Immunology , 2011, 通讯作者
（95） A pathogenic Vibrio harveyi lineage causes recurrent disease outbreaks in cultured Japanese flounder (Paralichthys olivaceus) and induces apoptosis in host cells, Aquaculture, 2011, 通讯作者
（96） Ferritin M of Cynoglossus semilaevis: an iron binding protein and a broad-spectrum antimicrobial that depends on the integrity of the ferroxidase center and nucleation center for biological activity., Fish and Shellfish Immunology , 2011, 通讯作者
（97） An inflammatory CC chemokine of Cynoglossus semilaevis is involved in immune defense against bacterial infection, Fish and Shellfish Immunology , 2011, 通讯作者
（98） Evaluation of housekeeping genes as references for quantitative real time RT-PCR analysis of gene expression in Japanese flounder (Paralichthys olivaceus)., Fish and Shellfish Immunology , 2011, 通讯作者
（99） HtpG is involved in the pathogenesis of Edwardsiella tarda, Veterinary Microbiology, 2011, 通讯作者
（100） A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum., Fish and Shellfish Immunology , 2011, 通讯作者
（101） Suppressor of cytokine signaling 3 inhibits head kidney macrophage activation and cytokine expression in Scophthalmus maximus, Developmental and Comparative Immunology , 2011, 通讯作者
（102） The tissue factor pathway inhibitor 1 of Sciaenops ocellatus possesses antimicrobial activity and is involved in the immune response against bacterial infection, Developmental and Comparative Immunology , 2011, 通讯作者
（103） The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation, Developmental and Comparative Immunology , 2011, 通讯作者
（104） CXCL8 of Scophthalmus maximus: expression, biological activity, and immunoregulatory effect, Developmental and Comparative Immunology , 2011, 通讯作者
（105） Construction and analysis of the immune effect of an Edwardsiella tarda DNA vaccine encoding a D15-like surface antigen, Fish and Shellfish Immunology, 2011, 通讯作者
（106） Identification and analysis of the tissue factor pathway inhibitor 2 of Sciaenops ocellatus. , Fish and Shellfish Immunology , 2011, 通讯作者
（107） The g-type lysozyme of Scophthalmus maximus has a broad substrate spectrum and is involved in the immune response against bacterial infection, Fish and Shellfish Immunology , 2011, 通讯作者
（108） Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: subunit vaccine vs DNA vaccine., Vaccine, 2011, 通讯作者
（109） A bivalent Vibrio harveyi DNA vaccine induces strong protection in Japanese flounder (Paralichthys olivaceus), Vaccine, 2011, 通讯作者
（110） Determination of internal controls for quantitative real time RT-PCR analysis of the effect of Edwardsiella tarda infection on gene expression in turbot (Scophthalmus maximus)., Fish and Shellfish Immunology , 2011, 通讯作者
（111） Interleukin-8 of Cynoglossus semilaevis is a chemoattractant with immunoregulatory property, Fish and Shellfish Immunology , 2011, 通讯作者
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