李博伟 - 中国科学院烟台海岸带研究所 -

个人简介

2001年本科毕业于厦门大学化学系，2009年博士毕业于中科院大连化物所后，在美国Florida State university从事博士后研究，2011年9月加入海岸带研究所，一直从事微流控芯片研究工作，申请人多年来一直致力于发展基于微流控芯片平台的化学和生物学领域的新原理、新方法研究，包括环境污染物快速检测和疾病早期诊断、微流控纸芯片传感微器件研发等。近年来以在 Angewandte Chemie International Edition、 Analytical Chemistry、 Biosensors & Bioelectronics、ACS Sensors等重要期刊发表论文。发表论文50余篇，其中SCI论文40余篇，影响因子大于10的5篇，影响因子大于5.0的21篇,总引用超1200余次，H-index=21,获得发明专利授权8项,主持国家自然科学基金面上项目和青年项目等多个项目。专利 [1] 李博伟,陈令新,齐骥,等. 一种基于离子印迹包被量子点检测液体样品的微流控纸芯片及其制备方法. 2016-12-26. [2] 陈令新,张忠,李博伟. 一种基于量子点的蛋白质印迹纸芯片的制备方法. 2015-04-23. [3] 丁家旺,李博伟,秦伟. 一种电位型纸芯片及其制备和应用. 2014-12-08. [4] 李博伟,陈令新,付龙文. 一种便携式纸基微流控芯片色彩检测装置和方法. 2012-12-27.

近期论文

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[1] Wang, Xiaoyan.,Yu, Shuangmei.,Wang, Jiangru.,Yu, Jialuo.,Arabi, Maryam.,...&Chen, Lingxin.(2020).Fluorescent nanosensor designing via hybrid of carbon dots and post- imprinted polymers for the detection of ovalbumin.TALANTA,211,120727. [2] 韩笑笑,齐骥,宋志花,等. 基于分子印迹的荧光传感技术及其应用研究[J]. 中国科学:化学,2020,50(04):463-475. [3] Zhou, JR.,Li, BW.,Qi, AJ.,Shi, YJ.,Qi, J.,...&Chen, LX.(2020).ZnSe quantum dot based ion imprinting technology for fluorescence detecting cadmium and lead ions on a three-dimensional rotary paper-based microfluidic chip.SENSORS AND ACTUATORS B-CHEMICAL,305,127462. [4] Zhang, Zhong.,Ma, Xin.,Li, Bowei.,Zhao, Jia.,Qi, Ji.,...&Yang, Xingbin.(2020).Fluorescence detection of 2,4-dichlorophenoxyacetic acid by ratiometric fluorescence imaging on paper-based microfluidic chips.ANALYST,145(3),963-974. [5] Liu, Ping.,Li, Bowei.,Fu, Longwen.,Huang, Yan.,Man, Mingsan.,...&Chen, Lingxin.(2020).Hybrid Three Dimensionally Printed Paper-Based Microfluidic Platform for Investigating a Cell's Apoptosis and Intracellular Cross-Talk.ACS SENSORS,5(2),464-473. [6] Lin, D.,Li, BW.,Qi, J.,Ji, XF.,Yang, SX.,...&Chen, LX.(2020).Low cost fabrication of microfluidic paper-based analytical devices with water-based polyurethane acrylate and their application for bacterial detection.SENSORS AND ACTUATORS B-CHEMICAL,303,127213. [7] Qi, J.,Li, BW.,Zhou, N.,Wang, XY.,Deng, DM.,...&Chen, LX.(2019).The strategy of antibody-free biomarker analysis by in-situ synthesized molecularly imprinted polymers on movable valve paper-based device.BIOSENSORS & BIOELECTRONICS,142,UNSP 111533. [8] Zhang, Xiaoyu.,He, Na.,Huang, Yan.,Yu, Fabiao.,Li, Bowei.,...&Chen, Lingxin.(2019).Mitochondria-targeting near-infrared ratiometric fluorescent probe for selective imaging of cysteine in orthotopic lung cancer mice.SENSORS AND ACTUATORS B-CHEMICAL,282,69-77. [9] Zhang, Z,Ma, X,Jia, MF,Li, BW,Rong, JH,&Yang, XB.(2019).Deposition of CdTe quantum dots on microfluidic paper chips for rapid fluorescence detection of pesticide 2,4-D.ANALYST,144(4),1282-1291. [10] 王冠,齐骥,戚安金,等. 基于印迹聚合物的微流控量子点纸基芯片检测环境中的镉、铅离子[J]. 分析试验室,2019,38(01):7-12. [11] Gao, Min,Wang, Rui,Yu, Fabiao,Li, Bowei,&Chen, Lingxin.(2018).Imaging of intracellular sulfane sulfur expression changes under hypoxic stress via a selenium-containing near-infrared fluorescent probe.JOURNAL OF MATERIALS CHEMISTRY B,6(41),6637-6645. [12] Qi, Ji,Li, Bowei,Wang, Xiaoyan,Fu, Longwen,Luo, Liqiang,&Chen, Lingxin.(2018).Rotational Paper-Based Microfluidic-Chip Device for Multiplexed and Simultaneous Fluorescence Detection of Phenolic Pollutants Based on a Molecular-Imprinting Technique.ANALYTICAL CHEMISTRY,90(20),11827-11834. [13] Wang, Jiangru.,Yu, Jialuo.,Wang, Xiaoyan.,Wang, Liyan.,Li, Bowei.,...&Chen, Lingxin.(2018).Functional ZnS:Mn(II) quantum dot modified with L-cysteine and 6-mercaptonicotinic acid as a fluorometric probe for copper(II).MICROCHIMICA ACTA,185(9). [14] Han, Jinglong,Qi, Anjin,Zhou, Junrui,Wang, Guan,Li, Bowei,&Chen, Lingxin.(2018).Simple Way To Fabricate Novel Paper-Based Valves Using Plastic Comb Binding Spines.ACS SENSORS,3(9),1789-1794. [15] Sun, Xiange.,Li, Bowei.,Tian, Chunyuan.,Yu, Fabiao.,Zhou, Na.,...&Chen, Lingxin.(2018).Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers.ANALYTICA CHIMICA ACTA,1007,33-39. [16] Han, Xiaoyue,Song, Xinyu,Li, Bowei,Yu, Fabiao,&Chen, Lingxin.(2018).A near-infrared fluorescent probe for sensitive detection and imaging of sulfane sulfur in living cells and &ITin vivo&IT.BIOMATERIALS SCIENCE,6(3),672-682. [17] Sun, Xiange.,Li, Bowei.,Qi, Anjin.,Tian, Chongguo.,Han, Jinglong.,...&Chen, Lingxin.(2018).Improved assessment of accuracy and performance using a rotational paper-based device for multiplexed detection of heavy metals.TALANTA,178,426-431. [18] Qi, Ji.,Li, Bowei.,Wang, Xinran.,Zhang, Zhong.,Wang, Zhuo.,...&Chen, Lingxin.(2017).Three-dimensional paper-based microfluidic chip device for multiplexed fluorescence detection of Cu2+ and Hg2+ ions based on ion imprinting technology.SENSORS AND ACTUATORS B-CHEMICAL,251,224-233. [19] Li, Bowei,Yu, Lijuan,Qi, Ji,Fu, Longwen,Zhang, Peiqing,&Chen, Lingxin.(2017).Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve.ANALYTICAL CHEMISTRY,89(11),5708-5713. [20] Li, Bowei.,Zhang, Zhong.,Qi, Ji.,Zhou, Na.,Qin, Song.,...&lxchen@yic.ac.cn.(2017).Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin.ACS SENSORS,2(2),243-250. [21] Ding, JW,Li, BW,Chen, LX,Qin, W,Qin, W ,&Qin, W .(2016).A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(42),13033-13037. [22] 于丽娟,贺志伟,魏梦琦,等. 回形针固定法制作三维(3D)微流控纸芯片[J]. 分析试验室,2016,35(5):611-614. [23] 王欣然,李博伟,尤慧艳,等. 基于量子点的荧光传感微流纸基芯片离子印迹法检测铜离子[J]. 分析化学,2015,43(10):1499-1504. [24] Wang Xin-Ran,Li Bo-Wei,You Hui-Yan,&Chen Ling-Xin.(2015).An Ion Imprinted Polymers Grafted Paper-based Fluorescent Sensor Based on Quantum Dots for Detection of Cu2+ Ions.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,43(10),1499-1504. [25] Yin, Kun.,Li, Bowei.,Wang, Xiaochun.,Zhang, Weiwei.,Chen, Lingxin.,...&lxchen@yic.ac.cn.(2015).Ultrasensitive colorimetric detection of Cu2+ ion based on catalytic oxidation of L-cysteine.BIOSENSORS & BIOELECTRONICS,64,81-87. [26] 李博伟,陈令新. 基于表面增强拉曼光谱微流控芯片的研究进展[J]. 分析测试学报,2015,34(3):302-307. [27] Li, Bowei,Fu, Longwen,Zhang, Wei,Feng, Weiwei,Chen, Lingxin,&Chen, LX .(2014).Portable paper-based device for quantitative colorimetric assays relying on light reflectance principle.ELECTROPHORESIS,35(8),1152-1159. [28] Zhang, Wei.,Li, Bowei.,Chen, Lingxin.,Wang, Yunqing.,Gao, Dingxue.,...&Wu, Aiguo.(2014).Brushing, a simple way to fabricate SERS active paper substrates.ANALYTICAL METHODS,6(7),2066-2071. [29] Qi, Nan.,Li, Bowei.,You, Huiyan.,Zhang, Wei.,Fu, Longwen.,...&lxchen@yic.ac.cn.(2014).Surface-enhanced Raman scattering on a zigzag microfluidic chip: towards high-sensitivity detection of As(III)ions.ANALYTICAL METHODS,6(12),4077-4082. [30] Zhang, Weiwei,Yin, Kun,Li, Bowei,&Chen, Lingxin.(2013).A glutathione S-transferase from Proteus mirabilis involved in heavy metal resistance and its potential application in removal of Hg2+.JOURNAL OF HAZARDOUS MATERIALS,261,646-652. [31] Li, Bowei,Zhang, Wei,Chen, Lingxin,&Lin, Bingcheng.(2013).A fast and low-cost spray method for prototyping and depositing surface-enhanced Raman scattering arrays on microfluidic paper based device.ELECTROPHORESIS,34(15),2162-2168. [32] Feng, Weiwei,Zhou, Na,Chen, Lingxin,&Li, Bowei.(2013).An optical sensor for monitoring of dissolved oxygen based on phase detection.JOURNAL OF OPTICS,15(5),55502. [33] Li, Qing-ling,Li, Bo-wei,Wang, Yun-qing,&Li, QL .(2013).Surface-enhanced Raman scattering microfluidic sensor.RSC ADVANCES,3(32),13015-13026.

个人简介

研究领域

近期论文