吴政 - 暨南大学 - 粤港澳中枢神经再生研究院

个人简介

吴政博士，2011年毕业于复旦大学生命科学院，同年进入宾夕法尼亚州立大学，师从原位神经再生先驱者陈功教授，进行博士后学习，并于2016年8月晋升为该校研究型助理教授，2020年9月全职加入暨南大学粤港澳中枢神经再生研究院，担任研究组长。目前，着手开发第二代原位细胞重编技术，在补充功能性神经元的基础上，纠正或减低致病基因的表达。已经参与完成多项NIH和Alzheimer association的基金项目，先后在Nature Communications， Cell Stem Cell和Molecular Neurodegeneration等杂志上发表多篇研究论文，并获得5项美国发明专利。

研究领域

主要研究神经退行性疾病发病机制和干预治疗，开发原位神经再生技术用于补充丢失的神经细胞。

近期论文

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(1). Zheng Wu, Matthew Parry, Xiao-Yi Hou, Min-Hui Liu, Hui Wang, Rachel Cain, Zi-Fei Pei, Yu-Chen Chen, Zi-Yuan Guo, Sambangi Abhijeet, Gong Chen. （2020）Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease. Nature Communications. Feb 27, 2020 (2). Zheng Wu*, QW Huo*, L Ren, FP Dong, MY Feng, Y Wang, YT Bai, B Lüscher, ST Li, GL Wang, C Long, Y Wang, G Chen. (2019) Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels. Molecular Brian. 2019, 15; 12(1):50. (*共同第一) (3). DY Jiang, Zheng Wu, CT Forsyth, Y Hu, SP Yee, G Chen. (2018) GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation. Molecular Brian. 2018, 11 (1), 31. (4). Y Wang, Zheng Wu*, YT Bai, GY Wu*, G Chen*. (2017) Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s disease. Molecular Neurodegeneration. 2017, 12:73. (*共同通讯). （5）. L Chen, L Wan, Zheng Wu, W Ren, Y Huang, B Qian, Y Wang. (2017) KCC2 downregulation facilitates epileptic seizures. Scientific Reports. Dec; 7(1):156. （6）. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Zheng, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G. (2016) KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. Jan 19; 113(3):751-6. （7）. Zheng Wu, Alan C. Foster, Ursula Staubli, Xia Wu, Chicheng Sun, Xin Tang, Yong-Xin Li, Gong Chen . (2015) Effects of 3-aminoglutarate, a “silent” false transmitter for glutamate neurons, on synaptic transmission and epileptiform activity. Neuropharmacology. Oct; 97:95-103. （8）. Zheng Wu, Ziyuan Guo, Marla Gearing, Gong Chen. (2014) Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model. Nature Communications. June 13, 2014. （9）. Wan L, Liu X, Wu Zheng, Ren W, Kong S, Dargham RA, Cheng L, Wang Y. (2014) Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons. Neurosci Bull. Oct; 30(5):866-76. （10）. Guo Z, Zhang L, Wu Zheng, Chen Y, Wang F, Chen G. (2014) In Vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’s Disease model. Cell Stem Cell. 14(2):188-202. （11）. Wu X*, Huang L*, Wu Zheng, Zhang C, Jiang D, Bai Y, Wang Y, Chen G. (2013) Homeostatic competition between phasic and tonic inhibition. J Biol Chem. 288(35):25053-65. （12）. Yajie Sun*, Zheng Wu*, Shuzhen Kong, Dongyun Jiang, Anar Pitre, Yun Wang, and Gong Chen. (2013) Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors. Mol Brain. 6:21. (*共同第一) （13）. Wu X, Wu Zheng, Ning G, Guo Y, Ali R, Macdonald RL, De Blas AL, Luscher B, Chen G. (2012) gamma-Aminobutyric Acid Type A (GABAA) Receptor Alpha Subunits Play a Direct Role in Synaptic versus Extrasynaptic Targeting. J Biol Chem. 287(33): 27417-27430. （14）. Qian B, Sun Y, Wu Zheng, Wan L, Chen L, Kong S, Zhang B, Zhang F, Wang ZY, Wang Y. (2011) Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats. Seizure. 20(4):312-9. （15）. Chen CR, Tan R, Qu WM, Wu Zheng, Wang Y, Urade Y, Huang ZL. (2011) Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts anti-epileptic effects via GABA-benzodiazepine receptor complex in mice, British Journal of Pharmacology. 164(5):1534-46. （16）. Zheng Wu*, Qi Xu*, Liecheng Wang, et al. (2009) Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats. Neurochemical Research. 34(8):1393–1400. (*共同第一) （17）. Zheng Wu, Xu Qi, Dehu Kong, et al. (2008) Temporal lobe epilepsy animal model established by stereotaxic microinjection of kainic acid. Neural Regeneration Research. 3(4), 436-440.