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1. Zhang Z, Jiang H, Zhang Y, Zhang D, Fawcett JP, Gu J*. Comprehensive Bioanalysis of Ultrahigh Molecular Weight, Highly Disperse Poly(ethylene oxide) in Rat via Microsolid Phase Extraction and RPLC-Q-Q-TOF Coupled with the MSALL Technique. Anal Chem. 2020; doi: 10.1021/acs.analchem.0c00189.
2. Zhang Z, Zhang Y, Song S, Yin L, Sun D, Gu J*. Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals. J Sep Sci. 2020; doi: 10.1002/jssc.201901340.
3. Wang T, Guo Y, He Y, Ren T, Yin L, Fawcett JP, Gu J*, Sun H*. Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein. Acta Pharm Sin B. 2020; doi:10.1016/j.apsb.2020.02.001
4. Wang H, Zheng M, Gao J, Wang J, Zhang Q, Fawcett JP, He Y*, Gu J*. Uptake and release profiles of PEGylated liposomal doxorubicin nanoparticles: A comprehensive picture based on separate determination of encapsulated and total drug concentrations in tissues of tumor-bearing mice. Talanta.2020; 208:120358.
5. Yin L, Ren T, Zhao S, Shi M*, Gu J*. Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique. Talanta. 2020; 206: 120184.
6. Su C, Liu Y, Li R, Wu W, Fawcett JP, Gu J*. Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems. Adv Drug Deliv Rev. 2019; 143: 97-114.
7. Yin L, Zhang Z, Liu Y, Gao Y, Gu J*. Recent advances in single-cell analysis by MSspectrometry. Analyst. 2019;144:824-845.
8. Yin L, Feng Y, Tong J, Guo Z, Zhang Y, Zhang Q, Sun Y, Fawcett JP, Gu J*. Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study. Anal Bioanal Chem. 2019;411:5139-5148.
9. Wang T, Yin L, Wang H, Fawcett JP, Gu J*. Development and application of a high-throughput liquid chromatography-tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine. J Pharm Biomed Anal. 2019;170:16-21.
10. Ren T, Zhang Z, Fawcett JP, Sun D*, Gu J*. Micro-solid phase extraction and LC-MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study. J Pharm Biomed Anal. 2019;166:13-19.
11. Zhang Z, Li R, Liu S, Yin L, Xu T, Fawcett JP, Gu J*. Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma. J Sep Sci. 2019;42:3033-3040.
12. Liang C, Sun H, Meng X, Yin L, Fawcett JP, Yu H, Liu T, Gu J*. Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry. Acta Pharm Sin B. 2018;8:228-234.
13. Lin W, Yin L, Sun T, Wang T, Xie Z, Gu J*, Jing X*. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules. 2018;19:1625-1634.
14. Su C, Liu Y, He Y*, Gu J*. Analytical methods for investigating in vivo fate of nanoliposomes: A review. J Pharm Anal. 2018;8:219-225.
15. Sun D, Su C, Liu Y, Meng X, Fawcett JP, Guo Y, Gu J*. A Unique Collision-Induced Dissociation Reaction of Cholamine Derivatives of Certain Prostaglandins. J Am Soc Mass Spectrom. 2018;29:2360-2367.
16. Sun D, Meng X, Ren T, Fawcett JP, Wang H, Gu J*. Establishment of a Charge Reversal Derivatization Strategy to Improve the Ionization Efficiency of Limaprost and Investigation of the Fragmentation Patterns of Limaprost Derivatives Via Exclusive Neutral Loss and Survival Yield Method. J Am Soc Mass Spectrom. 2018; 29:1365 -1375.
17. Su C, Yang H, Sun H, Fawcett JP, Sun D*, Gu J*. Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC-MS/MS. J Pharm Biomed Anal. 2018;158:288-293.
18. Ren T, Li R, Meng X, Fawcett JP, Sun D*, Gu J*. Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma. J Pharm Biomed Anal. 2018 ;151:260-265.
19. Zhou X#, Meng X#, Cheng L, Su C, Sun Y, Sun L, Tang Z, Fawcett JP, Yang Y*, Gu J*. Development and Application of an MSALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry. Anal Chem. 2017;89:5193-5200.
20. Cong Y, Hu L*, Zhang Z, Gao Y, Dong M, Qin H, Ye M*, Gu J, Zou H. Analysis of therapeutic monoclonal antibody glycoforms by mass spectrometry for pharmacokinetics study.Talanta,2017, 165:664-670.
21. Yin L, Su C, Ren T, Meng X, Shi M, Paul Fawcett J, Zhang M, Hu W, Gu J*. MSALL strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra. Analyst. 2017 ;142:4279-4288.
22. Su C, Sun H, Yang H, Yin L, Zhang J, Fawcett JP, Gu J*. A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study. Anal Bioanal Chem. 2017;409:6559-6565.
23. Meng X, Xu H, Zhang Z, Fawcett JP, Li J, Yang Y*, Gu J*. Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide. Anal Bioanal Chem. 2017;409:4885-4891.
24. Sun H, Zhang Q, Zhang Z, Tong J, Chu D*, Gu J*. Simultaneous quantitative analysis of polyethylene glycol (PEG), PEGylated paclitaxel and paclitaxel in rats by MS/MSALL technique with hybrid quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal. 2017;145:255-261.
25. Su C, Yang H, Meng X, Fawcett JP, Cao J, Yang Y*, Gu J*. Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. J Sep Sci, 2017, 40:1010- 1016.
26. Lu H, Su C, Yin L, Gu L, Gu J*, Chen X*. Liquid chromatography-tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma. J Pharm Anal. 2016; 6: 112-116.
27. Yang Z, Xu X, Sun L, Zhao X, Wang H, Fawcett JP, Yang Y*, Gu J*. Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2016, 1020: 36-42.
28. Sun H, Wang J, Sun Y, Peng W, Sun L, Yang Y*, Gu J*. Rapid and sensitive liquid chromatography with tandem mass spectrometry method for the simultaneous quantification of yonkenafil and its major metabolites in rat plasma. J Sep Sci. 2016, 39:3700-3708.
29. Yang Z, Sun L, Liang C, Xu Y, Cao J, Yang Y*, Gu J. Simultaneous quantitation of the diastereoisomers of scholarisine and 19-epischolarisine, vallesamine, and picrinine in rat plasma by supercritical fluid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. J Sep Sci. 2016, 39:2652-60.
30. Yang Z, Wang L, Xu M, Gu J, Yu L, Zeng S*. Simultaneous analysis of gemfibrozil, morphine, and its two active metabolites in different mouse brain structures using solid-phase extraction with ultra-high performance liquid chromatography and tandem mass spectrometry with a deuterated internal standard. J Sep Sci. 2016; 39:2087-96.
31. Yin L, Wang T, Shi M, Zhang Y, Zhao X, Yang Y*, Gu J*. Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring. J Sep Sci. 2016,39:964-72.
出版专著:
《缓控释制剂药物动力学》,科学出版社,2009年,合作主编
《临床药物动力学》,科学出版社,2010年,编委
学术会议:
1. Studies on the Fate of Nano-drug Delivery System in vivo, 4TH Ling-Nan International Forum on DMPK,广州,2019.
2. LC-MS for Bioanalysis of Therapeutic Peptides, Polymer Excipient and Nano-DDS, CPSA(Pharnaceutical Solutions through Analysis), 上海,2019.
3. Studies on DMPK of Nano-Carriers in vivo, The 2nd International Symposium on Advances in Pharmaceutical Analysis,法国里尔市,2018.
4. ASMS Conference on Mass Spectrometry and Allied Topics,美国加利福尼亚州,圣地亚哥市,2018.
5. ASMS Conference on Mass Spectrometry and Allied Topics,美国印第安纳州,印第安纳波利斯市,2017.
6. DMPK of Nano-DDS: Challenge and Our Strategies, Asian Federation of Pharmaceutical Sciences Conference 2017,厦门,2017.
7. Development of LC-HR-MS/MS with the swath technique for pharmacokinetic studies of PEG and pegylated drugs, 27th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2016),广州,2016.