王猛 - 中国科学院大学 - 生命科学学院

个人简介

招生专业 071005-微生物学 071010-生物化学与分子生物学 081703-生物化工招生方向合成生物学，生物学自动化，高通量筛选，天然产物生物合成教育背景 2005-09--2009-12 美国锡拉丘兹大学化学系博士学位 2001-09--2005-05 浙江大学化学系学士学位 2001-09--2005-05 浙江大学生物信息学第二学位工作简历 2015-05~现在, 中国科学院天津工业生物技术研究所, 研究员 2010-02~2015-04,伊利诺伊大学厄巴纳香槟分校, 博士后

近期论文

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（1） Directed evolution of xylose specific transporters to facilitate glucose-xylose co-utilization, Biotechnology and Bioengineering, 2016, 第 1 作者（2） Identification of an important motif that controls the activity and specificity of sugar transporters, Biotechnology and Bioengineering, 2016, 第 1 作者（3） Combined and Iterative Use of Computational Design and Directed Evolution for Protein-Ligand Binding Design, Methods in Molecular Biology, 2016, 第 1 作者（4） Development of a Synthetic Malonyl-CoA Sensor in Saccharomyces cerevisiae for Intracellular Metabolite Monitoring and Genetic Screening. ACS synthetic biology, ACS synthetic biology, 2015, 第 3 作者（5） Design and engineering of intracellular-metabolite-sensing/regulation gene circuits in Saccharomyces cerevisiae, Biotechnology and Bioengineering, 2015, 第 1 作者（6） Characterization and engineering of the adenylation domain of a NRPS-like protein: a potential biocatalyst for aldehyde generation, ACS catalysis, 2014, 第 1 作者（7） Resorcylic acid lactone biosynthesis relies on a stereo-tolerant macrocyclizing thioesterase, Organic Letters, 2014, 第 3 作者（8） Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism, Chemistry & Biology, 2013, 第 1 作者（9） Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster, Nature Communications, 2013, 第 4 作者（10） 6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective, Organic Letters, 2012, 第 2 作者（11） Biocatalyst development by directed evolution., Bioresource Technology, 2011, 第 1 作者（12） Microbial synthesis of drugs and fuels via synthetic biology, Chinese Bulletin of Life Sciences, 2011, 第 1 作者（13） A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading, Biochemistry, 2009, 第 1 作者（14） Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters, Bioorganic and Medicinal Chemistry Letter, 2009, 第 1 作者（15） Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains, Biochemistry, 2008, 第 1 作者（16） Synthesis of metronidazole esters and their monosaccharide ester derivatives, Enzyme Microbiology and Technology, 2006, 第 2 作者