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Bin Tan, Qingbo Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Naturally Occurring and Widespread Resistance to Bioactive Natural Products. ChemMedChem, 2023, DOI: 10.1002/cmdc.202300619 (invited review). Accepted manuscript online: 16 December 2023;
Kai Liu,# Jinyan Zhang,# Guangtao Zhang,#* Liping Zhang, Zhen Meng, Liang Ma, Wenjun Zhang, Weiliang Xiong, Yiguang Zhu, Binjun Wang,* Changsheng Zhang.* Deciphering Deoxynybomycin Biosynthesis Reveals Fe(II)/α-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition. Journal of the American Chemical Society, 2023, DOI: 10.1021/jacs.3c11772. Publication online 6 December, 2023.
Peng Jiang,# Hongbo Jin,# Guangtao Zhang, Wenjun Zhang, Wei Liu, Yiguang Zhu, Changsheng Zhang,* Liping Zhang.* A Mechanistic Understanding of the Distinct Regio- and Chemo-selectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angewandte Chemie International Edition, 2023, DOI: 10.1002/anie.202310728. Accepted manuscript online: 02 November 2023; Version of Record online: 14 November 2023;
Zhuangjie Fang, Qingbo Zhang,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin. Organic Letters, 2023, 25 (34): 6346-6351. DOI: 10.1021/acs.orglett.3c02231. Published online 22 August 2023; Published inissue 1 September 2023. ("Hot off the press" in Natural Product Reports, 2023, 40 (10): 1590-1594. DOI: 10.1039/D3NP90045B).
Xiaoyang Zhao#, Youzhe Chen#, Ting Long, Zhiying Liu, Qingbo Zhang, Haibo Zhang, Yan Yan, Changsheng Zhang*, Yiguang Zhu*. Genome Mining and Biosynthetic Reconstitution of Fungal Depsidones Reveal a Dual Functional Cytochrome P450 for Ether Formation. Journal of Natural Products, 2023, 86 (8): 2046–2053. DOI: 10.1021/acs.jnatprod.3c00609. Published online 11 August 2023; Published inissue 25 August 2023.
Ke-Gang Linghu, Tian Zhang, Guang-Tao Zhang, Peng Lv, Wen-Jun Zhang, Guan-Ding Zhao, Shi-Hang Xiong, Qiu-Shuo Ma, Ming-Ming Zhao, Meiwan Chen, Yuan-Jia Hu, Changsheng Zhang,* Hua Yu.* Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy. Journal of Pharmaceutical Analysis, 2023, DOI: 10.1016/j.jpha.2023.07.009. Pre-proof Available online 17 July 2023.
Mengyi Zhu,# Lijuan Wang,# Haibo Zhang, Liping Zhang, Bin Tan, Qi Huang, Yiguang Zhu, and Changsheng Zhang*. Biosynthesis and engineered overproduction of everninomicins with promising activity against multidrug-resistant bacteria. ACS Synthetic Biology, 2023, DOI: 10.1021/acssynbio.3c00055. Published online 21 April 2023;
Bin Tan#, Liping Zhang#, Qingbo Zhang#, Siqiang Chen, Weiliang Xiong, Yiguang Zhu*, Changsheng Zhang*. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, DOI: 10.1002/anie.202302043. First published online 19 April 2023;
Lijuan Wang#, Mengyi Zhu#, Qingbo Zhang, Shilan Zhai, Yiguang Zhu, Haibo Zhang*, and Changsheng Zhang*. Biosynthetic diversification of fidaxomicin aglycones by heterologous expression and promoter refactoring. Journal of Natural Products, 2023, 86 (4): 986–993. DOI: 10.1021/acs.jnatprod.3c00001. Published online 12 April 2023; Published in issue April 28 2023.
Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang*, Qingbo Zhang*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979–985. DOI: 10.1021/acs.jnatprod.2c01169. Published online 15 March 2023; Published in issue April 28 2023.
Ziqian Cheng, Qingbo Zhang, Jing Peng, Xiaoyang Zhao, Liang Ma, Changsheng Zhang*, Yiguang Zhu*. Genomics-Driven Discovery of Benzoxazole Alkaloids from the Marine-Derived Micromonospora sp. SCSIO 07395. Molecules, 2023, 28 (2): 821. DOI: 10.3390/molecules28020821. Published 13 January 2023.
in Tan,# Qingbo Zhang,# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu*, and Changsheng Zhang*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, 41, 1478–1484. DOI: 10.1002/cjoc.202200818. First Published 17 January 2023; Version of Record online: 30 March 2023; (Preprint January 06 2023, DOI: 10.22541/au.167303804.43320409/v)
Bin Tan, Qingbo Zhang*, Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84. DOI: 10.1021/acs.jnatprod.2c00772. Published online 6 January 2023; Published in issue 27 January 2023.
Xuemin Ding, Weixia Ye, Bin Tan, Qiaoyun Song, Yuchan Chen, Wei Liu, Lili Sun, Wei Tang, Yulei Qiao, Qingbo Zhang, Haibo Zhang, Ying Wang, Weimin Zhang, Changsheng Zhang*, Wenjun Zhang*. Talachalasins A-C, undescribed cytochalasans with a 16β-methyl or 2-oxabicyclo[3.3.1]nonan-3-one unit from the deep-sea-derived fungus Talaromyces muroii sp. SCSIO 40439. Chinese Journal of Chemistry, 2023, 41 (8): 915–923. DOI: 10.1002/cjoc.202200744. First published: 05 January 2023; Version of Record online: 23 February 2023; Issue Online: 15 March 2023.
Chunyan Fang, Qingbo Zhang, Wenjun Zhang, Changsheng Zhang*, and Yiguang Zhu*. Discovery of efrotomycin congeners and heterologous expression-based insights into the self-resistance mechanism. Journal of Natural Products, 2022, DOI: 10.1021/acs.jnatprod.2c00986. Epub 29 November 2022.
Bin Tan, Qingbo Zhang*, Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis. Tetrahedron, 2022, 127: 133103. DOI: 10.1016/j.tet.2022.133103. Epub 29 October 2022.
Tingting Xu,# Qingqing Gan,# Qiang Liu, Ruidong Chen, Xuhui Zhen, Changsheng Zhang and Jinsong Liu*. Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel activator-dependent form of GT family. Acta Crystallographica Section D Structural Biology, 2022, 78 (10): 1235-1248. DOI: 10.1107/S2059798322008658. Epub 27 September 2022.
Chunfang Yang,# Liping Zhang,# Wenjun Zhang, Chunshuai Huang, Yiguang Zhu, Xiaodong Jiang, Wei Liu, Mengran Zhao, Bidhan Chandra De, Changsheng Zhang*. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. Nature Communications, 2022, 13, 5386. DOI: 10.1038/s41467-022-33131-0. Epub 2022 Sept 14.
Bidhan Chandra De#, Wenjun Zhang#, Chunfang Yang, Attila Mándi, Chunshuai Huang, Liping Zhang, Wei Liu, Mark W Ruszczycky, Yiguang Zhu, Ming Ma, Ghader Bashiri, Tibor Kurtán, Hung-wen Liu*, Changsheng Zhang*. Flavin-enabled reductive and oxidative epoxide ring opening reactions. Nature Communications, 2022, 13: 4896. DOI: 10.1038/s41467-022-32641-1. Epub 2022 Aug 20.
Wei Liu, Liang Ma, Li-Ping Zhang, Yu-Chan Chen, Qing-Bo Zhang, Hai-Bo Zhang, Wei-Min Zhang, Changsheng Zhang*, Wen-Jun Zhang*. Two new phenylhydrazone derivatives from the Pearl River estuary sediment-derived Streptomyces sp. SCSIO 40020. Marine Drugs, 2022, 20 (7): 449. DOI: 10.3390/md20070449. Epub 2022 Jul 09.
张海波, Imran Khan, Kumar Saurav, 张丽萍, 方壮杰, 张鑫雅, 彭方, 张长生. 鲸鱼骨来源真菌Penicillium sp. S2014503的生物活性成分[J]. 热带海洋学报, 2022, (): 0-0. DOI: 10.11978/2022074. Epub 2022 May 16.
朱义广，牟鹏云，张庆波，张长生。中国南海来源真菌Penicillium sp. SCSIO 40438次级代谢产物研究。热带海洋学报, 2022, DOI: . Epub 2022 May 10.10.11978/2022079
Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang*. Antifungal Macrolides Kongjuemycins from Coral-associated Rare Actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic Letters, 2022, 24 (19): 3482–3487. DOI: 10.1021/acs.orglett.2c01089. (selected as Supplementary cover article) Epub 2022 April 27.
龙婷，张庆波，牟鹏云，王俊锋，张长生*，朱义广*。海洋来源节菱孢菌ZSDS1-F3中PKS-NRPS类天然产物挖掘。微生物学报，2022, 62 (8): 3224-3235. DOI: 10.13343/j.cnki.wsxb.20210783. Epub 2022 Apr 21.
王璐，叶伟霞，赵梦冉，张庆波，张丽萍，张长生，张文军*。湛江红树林内生真菌分离筛选及Stemphyliums sp. SCSIO 40436代谢产物研究。微生物学通报，2022, 49 (8): 2995-3007. DOI: 10.13344/j.microbiol.china.211223. Epub 2022 Apr 01.
赵梦冉，王璐，叶伟霞，张庆波，马亮，张丽萍，张文军，张长生，杨春芳*。湛江高桥红树林沉积物放线菌多样性及其中一株链霉菌产生的germicidins类化合物的鉴定。微生物学报， 2022, 62 (5): 1740-1753. DOI: 10.13343/j.cnki.wsxb.20210531 ; CNKI. Epub 2022 Feb 23.
徐慧欣，王 璐，张丽萍，刘威，张庆波，张海波，张长生，张文军*。Malfilamentoside A 的构型确定与新呋喃糖苷类化合物malfilamentoside D。 有机化学，2022, DOI: 10.6023/cjoc2021110038. Epub 2021 Dec 30.
叶伟霞，赵梦冉，王璐，蒋晓东，张文军，张长生，田海妍*。南海珊瑚来源真菌Aspergillus sp. SCSIO 40435的分离鉴定及其次级代谢产物研究。微生物学报，2022, .62 (5): 1819–1831. DOI: ; . 10.13343/j.cnki.wsxb.20210568CNKIEpub 2021 Nov 25
Xiao-Zhen Wu, Wen-Jun Huang, Wei Liu, Attila Mándi, Qingbo Zhang, Liping Zhang, Wenjun Zhang, Tibor Kurtán, Cheng-Shan Yuan,* Changsheng Zhang.* Penicisteckins A‒F, Isochroman-Derived Atropisomeric Dimers from Penicillium steckii HNNU-5B18. Journal of Natural Products, 2021, 84 (11): 2953–2960. DOI: 10.1021/acs.jnatprod.1c00787. Epub 2021 Nov 17.
Ruoxuan Bao,# Yongmei Meng,# Haibo Zhang, Chen Yang, Wei Li, Cheng Zhang, Jinye Zhang, Renqiang Sun, Zengxia Li, Wei Jiang, Chensong Zhang, Changsheng Zhang,* Hai-Xin Yuan,* Yongjun Dang.* Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death & Disease, 2021,12, Article number: 972. DOI: 10.1038/s41419-021-04264-9. Epub 2021 Oct 20.
Bidhan Chandra De, Wenjun Zhang, Guangtao Zhang, Zhiwen Liu, Bin Tan, Qingbo Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Host-dependent Heterologous Expression of Berninamycin Gene Cluster Leads to Linear Thiopeptide Antibiotics. Organic & Biomolecular Chemistry, 2021, 19 (41): 8940-8946. DOI: 10.1039/D1OB01759D. Epub 2021 Oct 1. ("Hot off the press" in Natural Product Reports, 2021, 38 (12): 2139-2144. DOI: 10.1039/D1NP90046C)
翟诗岚，刘威，吴正超，朱义广，张文军，张长生，马亮*。 珠江口沉积物来源链霉菌SCSIO 40020中bafilomycins的鉴定及其生物合成基因簇的异源表达。微生物学报, 2021, 61 (12): 3991-4005. 摘要 DOI: 10.13343/j.cnki.wsxb.20210121. Epub 2021 Sept 14.
Haibo Zhang, Liping Zhang, Imran Khan, Guangtao Zhang, Yiguang Zhu & Changsheng Zhang.* A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds. SCIENCE CHINA Chemistry, 2021, DOI: 10.1007/s11426-021-1072-6. Epub 2021 Aug 31.
Chunshuai Huang, Chunfang Yang,* Wenjun Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of An Unexpected 1,4-Oxazepine-Linked Seco-Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP. Journal of Natural Products, 2021, 84 (8): 2336–2344. DOI: 10.1021/acs.jnatprod.1c00461. Epub 2021 Aug 12.
Lu Wang,# Yanbing Huang,# Liping Zhang, Zhiwen Liu, Wei Liu, Huixin Xu, Qingbo Zhang, Haibo Zhang, Yan Yan, Zhiyong Liu, Tianyu Zhang, Wenjun Zhang,* Changsheng Zhang.* Structures and Absolute Configurations of Phomalones from Coral-associated fungus Parengyodontium album sp. SCSIO 40430. Organic & Biomolecular Chemistry, 2021, 19 (27): 6030-6037. DOI: 10.1039/d1ob00869b. Epub 2021 Jun 29.
Pengyun Mou, Qingbo Zhang, Jing Peng, Xiaodong Jiang, Liping Zhang, Zhongbo Zhou,* Changsheng Zhang, Yiguang Zhu*. Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434. Fitoterapia, 2021, 152: 104937. DOI: 10.1016/j.fitote.2021.104937. Epub 2021 May 15.
金红波，张丽萍，张文军，张光涛，朱义广，刘威，张长生*。斑鸠霉素氧化酶CftA体外生物活性研究。微生物学通报，2021，48 (7): 2389-2397. DOI: 10.13344/j.microbiol.china.210150. Epub 2021 Apr 27.
Xiaodong Jiang, Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang.* Discovery of a New Asymmetric Dimer Nenestatin B and Implications of Dimerizing Enzyme in a Deep Sea Actinomycete. Organic & Biomolecular Chemistry, 2021,19 (19): 4243-4247. DOI: 10.1039/d1ob00310k. Epub 2021 Apr 22. ("Hot off the press" in Natural Product Reports, 2021, 38 (8): 1418-1422. DOI: 10.1039/D1NP90030G)
Jing Peng, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Ting Long, Ziqian Cheng, Changsheng Zhang,* Yiguang Zhu*. New piericidin derivatives from a marine-derived Streptomyces sp. SCSIO 40063 with cytotoxicity activity. Natural Product Research, 2021, DOI: 10.1080/14786419.2021.1901699. Epub 2021 Mar 19.
Xinya Zhang,# Siqiang Chen,# Liping Zhang, Qingbo Zhang, Wenjun Zhang, Yuchan Chen, Weimin Zhang, Haibo Zhang,* and Changsheng Zhang.* Dassonmycins A and B, Polycyclic thioalkaloids from a marine sponge-derived Nocardiopsis dassonvillei SCSIO 40065. Organic Letters, 2021, 23 (8): 2858–2862. DOI: 10.1021/acs.orglett.1c00328. ( Front Cover paper ). Epub 2021 Mar 11. ("Hot off the press" in Natural Product Reports, 2021, 38 (6): 1053-1057. DOI: 10.1039/D1NP90020J).
Imran Khan, Jing Peng, Zhuangjie Fang, Wei Liu, Wenjun Zhang, Qingbo Zhang, Liang Ma, Guangtao Zhang, Changsheng Zhang* and Haibo Zhang.* Cylindromicin from arctic-derived fungus Tolypocladium sp. SCSIO 40433. Molecules, 2021, 26(4): 1080. DOI: 10.3390/molecules26041080. Epub 2021 Feb 18.
Hui-Xin Xu, Ting Yang, Li-Ping Zhang, Wei Liu, Hai-Bo Zhang, Qing-Bo Zhang, Chang-Sheng Zhang*, Wen-Jun Zhang*. Ocauxarthrol A from Auxarthron umbrinum SCSIO 40432 and configurational reassignment of chrysoqueen and auxarthrols. Tetrahedron Letters, 2021, 66: 152842. DOI: 10.1016/j.tetlet.2021.152842. Epub 2021 Feb 4.
Chunfang Yang,# Chunshuai Huang,# Chunyan Fang, Liping Zhang, Siqiang Chen, Qingbo Zhang, Changsheng Zhang*, Wenjun Zhang*. Inactivation of flavoenzyme-encoding gene flsO1 in fluostatin biosynthesis leads to diversified angucyclinone derivatives. Journal of Organic Chemistry, 2021, 86 (16): 11019–11028. DOI: 10.1021/acs.joc.0c02517. (Supplementary cover article) ("Hot off the press" in Natural Product Reports, 2021, DOI: 10.1039/d1np90037d). Epub 2021 Feb 3.
Liang Ma, Wenjun Zhang, Zhiwen Liu, Yanbing Huang, Qingbo Zhang, Xinpeng Tian, Changsheng Zhang, Yiguang Zhu.* Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products. Marine Genomics, 2021, 55: 100803. DOI: 10.1016/j.margen.2020.100803. Epub 2020 Jul 9.
Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, and Changsheng Zhang. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research, 2021, 35(2):188-194. DOI: 10.1080/14786419.2019.1616729 .Epub 2019 May 29.
Siqiang Chen, Qingbo Zhang, Xinya Zhang, Xiaodong Jiang, Haibo Zhang, Yiguang Zhu, Changsheng Zhang, and Liping Zhang.* A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064. Natural Product Research, 2020, DOI: 10.1080/14786419.2020.1867131. Epub 2020 Dec 30.
方春艳, 朱义广, 张长生, 张庆波*。PPtase高表达海洋放线菌Streptomyces sp. SCSIO 40060的次级代谢产物研究。中国海洋药物，2020, 39 (6): 12-18. HTML Epub 2020 Dec 15.
Liping Zhang,# Bidhan Chandra De,# Wenjun Zhang,* Attila Mándi, Zhuangjie Fang, Chunfang Yang, Yiguang Zhu, Tibor Kurtán, and Changsheng Zhang.* Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U. Journal of Biological Chemistry, 2020, 295 (50): 16987-16997. DOI: 10.1074/jbc.RA120.015563 . Epub 2020 Oct 1.
Zhuangjie Fang,# Xiaodong Jiang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu,Changsheng Zhang.* S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130. DOI: 10.1021/acs.jnatprod.0c00719. Epub 2020 Sep 24.
Jinxin Xu,#,* Xiaowen Tang,# Yiguang Zhu, Zhijun Yu, Kai Su, Yulong Zhang, Yan Dong, Weiming Zhu, Changsheng Zhang, Ruibo Wu, Jinsong Liu.* Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition. Communications Biology, 2020, 3(1): 455. DOI: 10.1038/s42003-020-01184-w. Epub 2020 Aug 19.
Imran Khan, Haibo Zhang,* Wei Liu, Liping Zhang, Fang Peng, Yuchan Chen, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, and Changsheng Zhang.* Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019. RSC Advances, 2020, 10 (35): 20738-20744. DOI: 10.1039/D0RA03529G. Epub 2020 Jun 2.
Ling Liu, Sainan Li, Runze Sun, Xiangjing Qin, Jianhua Ju, Changsheng Zhang, Yanwen Duan,* and Yong Huang.* Activation and characterization of bohemamine biosynthetic gene cluster from Streptomyces sp. CB02009. Organic Letters, 2020, 22 (12): 4614–4619. DOI: 10.1021/acs.orglett.0c01224. Epub 2020 May 28.
Yuanqi Wang, Changsheng Zhang, Yilei Zhao*, Rosalinda Zhao, Kendall Houk. Understand the specific regio- and enantioselectivity of fluostatin conjugation in the post-biosynthesis. Biomolecules, 2020, 10 (6): 815. DOI: 10.3390/biom10060815. Epub 2020 May 26.
Yiguang Zhu,# Qingbo Zhang,# Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu,* and Changsheng Zhang.* Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069. DOI: 10.1002/anie.202004978 and 10.1002/ange.202004978. Epub 2020 Apr 23.
Wei Liu,‡ Vinay Gopal Jannu,‡ Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang* and Yiguang Zhu*. Heterologous expression of the trichostatin gene cluster and functional characterization of the N-methyltransferase TsnB8. Organic & Biomolecular Chemistry, 2020, 18 (19): 3649-3653. DOI: 10.1039/d0ob00617c. Epub 2020 Apr 23.
Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan,* and Shoudeng Chen.* Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharmaceutica Sinica B (APSB), 2020, DOI: 10.1016/j.apsb.2020.04.009. Epub 2020 Apr 20.
Chunyan Fang, Qingbo Zhang, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Liang Ma, Haibo Zhang, and Changsheng Zhang.* Proximicins F and G and diproximicin A: aminofurans from the marine-derived Verrucosispora sp. SCSIO 40062 by overexpression of PPtase genes. Journal of Natural Products, 2020, 83 (4): 1152-1156. DOI: 10.1021/acs.jnatprod.9b01185. Epub 2020 Mar 19.
Bin Tan,# Qingbo Zhang,# Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang.* Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides. ACS Chemical Biology, 2020, 15 (3): 766-773. DOI: 10.1021/acschembio.9b00997. Introducing Our Authors for Bin Tan (DOI: 10.1021/acschembio.0c00202). Epub 2020 Mar 9.
Mahder S. Manenda, Marie-Ève Picard, Liping Zhang, Normand Cyr, Xiaojun Zhu, Julie Barma, Manon Couture, Changsheng Zhang, and Rong Shi.* Structural analyses of the group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. Journal of Biological Chemistry, 2020, 295 (14): 4709-4722. DOI: 10.1074/jbc.RA119.011212. Epub 2020 Feb 28.
Hongbo Jin, Wenjun Zhang, Guangtao Zhang, Liping Zhang, Wei Liu, and Changsheng Zhang.* Engineered biosynthesis of 5/5/6 type polycyclic tetramate macrolactams in an ikarugamycin (5/6/5 type)-producing chassis. Organic Letters, 2020, 22 (5): 1731-1735. DOI: 10.1021/acs.orglett.9b04672. Epub 2020 Feb 13. ("Hot off the press" in Natural Product Reprots, 2020, 37 (4): 472-476. DOI: 10.1039/D0NP90014A)
Bin Tan,# Siqiang Chen,# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang, and Changsheng Zhang.* Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066. DOI: 10.1021/acs.orglett.9b04597. Epub 2020 Jan 23.
Liang Ma, Qingbo Zhang, Chunfang Yang, Yiguang Zhu, Liping Zhang, Lijuan Wang, Zhiwen Liu, Guangtao Zhang, and Changsheng Zhang*. Assembly line and post-PKS modifications in the biosynthesis of marine polyketide natural products. Book chapter in: Comprehensive Natural Products III: Chemistry and Biology. Book editor, Begley, T. P. & H.-w. Liu; Volume editor, Y. Tang, 2020, Volume 1: 139-197. DOI: 10.1016/B978-0-12-409547-2.14711-0. Epub 2019 Nov 23.
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