喻子牛 - 中国科学院大学

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喻子牛博导收藏完善纠错
中国科学院大学海洋学院
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个人简介

招生专业 Major 070703-海洋生物学 Marine biology -遗传学 Genetics -分子生物学 Molecular Biology 070703-海洋生物学 Marine biology 招生方向 Fields 海洋生物技术 Marine Biotechnology 海洋动物遗传学与分子生物学 Genetics and Molecular Biology of Marine Animals 教育背景与所获学位 Education & Degrees earned 学历和学位 Education history & Degrees 1979.09-83.06, 湖南师范大学, 生物学, 学士(BSc); 1983.09-86.06, 山东大学, 发育生物学, 硕士(MSc); 1994.09-97.06, 青岛海洋大学, 海洋生物遗传学, 博士(Ph.D). 国外工作经历 Overseas Experience 1997.08-98.12 博士后 (Postdoctoral fellow), 美国特拉华大学海洋学院 (College of Marine Studies, University of Delaware, USA) 2000.09-01.02 访问学者 (Visiting scholar), 美国新泽西州立大学海洋与海岸科学学院 (Inst. Marine & Coastal Sciences, State University of New Jersey, USA) 2001.06-04.12 高级研究助理 (Senior research associate)，美国新泽西州立大学海洋与海岸科学学院 (Inst. Marine & Coastal Sciences, State University of New Jersey, USA) 工作经历 Work experience 1986.07-89.11 助教，青岛海洋大学水产学院； 1989.12-94.11 讲师，青岛海洋大学水产学院； 1994.12-97.11 副教授，青岛海洋大学水产学院； 1997.12-03.10 教授，青岛海洋大学水产学院； 2005.01- 现在责任研究员，中国科学院南海海洋研究所。专利成果 Patents 1. 太平洋牡蛎EST微卫星标记的筛选方法. 发明（设计）人: 喻子牛; 王艳红申请号: CN200710027648.8; 分类号: C12Q1/68(2006.01)I; C12N15/11(2006.01)I 授权公告号: CN100532573; 授权公告日: 2009.08.26 2. 华贵栉孔扇贝微卫星标记的构建方法. 发明（设计）人: 王艳红; 喻子牛申请号: CN200710027648.8; 分类号: C12Q1/68(2006.01)I; C12N15/11(2006.01)I;C12P19/34(2006.01)I 授权公告号: CN100552042; 授权公告日: 2009.10.21 3. 华南沿海七种巨蛎属牡蛎的PCR-RFLP鉴别方法，发明（设计）人: 喻子牛; 夏建军公开号：CN101130815A 4. 一种贝类凝集素基因及其应用。发明（设计）人: 陈金辉; 喻子牛; 张扬公开号：CN 102250909 A 5.张扬,张跃环,李军,喻子牛；一种新型特异结合LPS的贝类模式识别受体LRRP；专利号: ZL 201410075253.5 6. 向志明；瞿符发；肖述；喻子牛；一种血清淀粉样蛋白A及其编码基因和应用；专利号：ZL201410084163.2 7.向志明；瞿符发；肖述；喻子牛；一种纤维胶凝蛋白及其编码基因和应用；专利号：ZL 201410137128.2； 8. 张跃环, 喻子牛, 肖述, 张扬. 一种香长杂交牡蛎新品系的培育方法. 专利号: ZL201410073712.6 9.张跃环, 喻子牛, 肖述, 张扬. 一种长杂回交牡蛎新品系的培育方法. 专利号: ZL201410073380.1 10.张跃环, 喻子牛, 肖述, 张扬. 一种香杂回交牡蛎新品系的培育方法. 专利号:ZL201410072753.3 11. 张跃环, 喻子牛, 肖述, 张扬. 一种固定牡蛎远缘杂种回交优势的育种方法. 专利号: ZL201310700355.7 12.张跃环, 喻子牛, 肖述, 张扬. 一种牡蛎种间核质互换品系的制种方法. 专利号: ZL201410072660.0 科研项目 Grants & Fundings 1、NSFC-广东联合基金重点项目近江牡蛎广盐高温耐受/适应性及高效生物矿化的基因资源发掘与分子调控研究 2013-16 2、国家973计划课题贝类抗病和抗逆的关键基因及其网络调控机制 2010-14 3、院知识创新工程重要方向项目子课题牡蛎养殖生产与初级生产力的关系 2009-11 4、国家公益性行业专项贝类良种选育体系建设 2008-10 5、国家现代农业技术体系建设专项国家贝类产业技术研发中心 2008-12 6、国家海洋生物技术863项目香港巨牡蛎优质、高产、抗逆品种的培育 2006-10 7、中国科学院资助项目中国科学院“****”入选者研究课题， 2005-08 8、国家自然科学基金项目太平洋牡蛎多态EST标记开发及其基因组作图研究 2006-08 9、国家自然科学基金项目华贵栉孔扇贝微卫星分子标记开发及连锁图构建 2008-10 10、广东省科技计划项目近江牡蛎健康苗种规模化培育与良种选育关键技术研究 20113-15 11、广东省自然科学基金重点课题近江牡蛎基因组和EST微卫星标记开发及连锁图构建 2009-11 12、广东省科技计划项目近江牡蛎高生长率品种的良种选育及应用示范 2008-10。科研项目 Grants & Fundings 1、国家973计划课题贝类抗病和抗逆的关键基因及其网络调控机制 2010-14 2、院知识创新工程重要方向项目子课题牡蛎养殖生产与初级生产力的关系 2009-11 3、国家公益性行业专项贝类良种选育体系建设 2008-10 4、国家现代农业技术体系建设专项国家贝类产业技术研发中心 2008-12 5、国家海洋生物技术863项目香港巨牡蛎优质、高产、抗逆品种的培育 2006-10 6、中国科学院资助项目中国科学院“****”入选者研究课题， 2005-08 7、国家自然科学基金项目太平洋牡蛎多态EST标记开发及其基因组作图研究 2006-08 8、国家自然科学基金项目华贵栉孔扇贝微卫星分子标记开发及连锁图构建 2008-10 9、广东省自然科学基金重点课题近江牡蛎基因组和EST微卫星标记开发及连锁图构建 2009-11 10、广东省科技计划项目近江牡蛎高生长率品种的良种选育及应用示范 2008-10 合作情况 Collaborations

研究领域

(1) 贝类遗传学与育种研究 (Genetics and Breeding Studies of Mollusks)：开发、利用微卫星、线粒体DNA等分子标记，进行遗传多样性、群体遗传结构解析、育种过程中遗传变化的监测与评价、种类鉴定等；通过连锁分析进行遗传连锁图构建。利用家系选择、群体选择、多倍体诱导及杂交等方法和分子标记进行牡蛎优良品种培育；开展南海砗磲等珍稀贝类的人工繁育、培育和人工放流增殖。 (2) 贝类功能基因与基因组学 (Gene and Genomics Studies of Mollusks)：利用各种分子生物学技术和生物信息学方法, 以及转录组、表达谱、蛋白组分析，研究性状表达的分子机理，解析基因组特征；通过性状相关的功能基因筛选、克隆、表达分析，研究其分子水平的功能和调控，为性状解析和良种培育提供可供利用的基因、基因组信息和工具。 (3) 贝类线粒体基因组与分子系统学 (Mitochondrial Genome and Molecular Phylogenetics in Mollusks)：通过线粒体基因组测序和分析，运用分子系统学理论和方法，研究、比较贝类线粒体基因组的结构与变化、基因重排及其进化，进行种类鉴定；解析并探讨贝类种、属、科等各种类间、类群间的系统关系和地位。

近期论文

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1. Mao F., K. Liu, Y. Lin, Z. He, J. Li, Z. Xiang, Y. Zhang* and Z. Yu*, 2020, Opsonic character of the plasma proteins in phagocytosis-dependent host response to bacterial infection in a marine invertebrate, Crassostrea gigas. Develop. Comp. Immunol. 106 :103596 2. Zhou Z., J. Li, Y. Qin, Y. Zhou, Y. Zhang*, Z. Yu* etc., 2020, Artificial interspecific hybridization of two giant clams, Tridacna squamosa and Tridacna crocea, in the south China sea. Aquaculture, 515:734581. 3. Liu, Y., Mao F., X. Zhang, Z. He, J. Li, Z. Xiang, Y. Zhang* and Z. Yu*, 2020, Phagocyte Transcriptomic Analysis Reveals Focal Adhesion Kinase (FAK) and Heparan Sulfate Proteoglycans (HSPGs) as Major Regulators in Anti-bacterial Defense of Crassostrea hongkongensis. Frontiers in Immunology. 11:416. 4. Zhang, Y., H. Ma. J. Li, Z.. Zhou, Y. Qin, Z. Yu* etc., 2020, Analysis of inbreeding depression on performance traits of three giant clams (Tridacna derasa, T. squamosa, and T. crocea) in the South China Sea. Aquaculture, 521: 735023. 5. Liu, Y., Mao F., X. Zhang, Z. He, J. Li, Z. Xiang, Y. Zhang* and Z. Yu*, 2020, TRAF6 suppresses the apoptosis of hemocytes by activating pellino in Crassostrea hongkongensis. Develop. Comp. Immunol. 103:103501. 6. Qin, Y., Zhang, Y., H. Ma. J. Li, Z.. Zhou, Z. Yu* etc., 2020, Characterization and functional analysis of a caspase 3 gene: Evidence that ChCas 3 participates in the regulation of apoptosis in Crassostrea hongkongensis. Fish & Shellfish Immunology, 98:122-129. 7. Zhang, Y., Y. Qin, J. Li, Z.. Zhou, S. Xiao, Z. Yu* etc., 2019, Gametogenesis From the Early History Life Stages of the Kumamoto Oyster Crassostrea sikamea and Their Breeding Potential Evaluation. Frontiers in Physiology, 5(10) :524. 8. Ma, H., Y. Zhang, S. Xiao, Y. Zhang, Z. Xiang and Z. Yu* etc., 2019, The complete mitochondrial genome of giant clam, Hippopus hippopus (Cardiidae: Tridacninae). Conservation Genetics Resources. 11(3) : 263 -266. 9. Wu, X., Zhang, Y., Y. Qin, S. Xiao, Z. Yu* etc., 2019, Comparative studies of the growth, survival, and reproduction of diploid and triploid Kumamoto oyster, Crassostrea sikamea. J World Aquacult Soc. 1-12. 10. Qin, Y., Y. Zhang, R. Mo, Y. Zhang*, Z. Yu* et al, 2019, Influence of ploidy and environment on grow-out traits of diploid and triploid Hong Kong oysters Crassostrea hongkongensis in southern China. Aquaculture, 507: 108-118. 11. Mao F., Y. Lin, Z. He, J. Li, Z. Xiang, Y. Zhang* and Z. Yu*, 2018, Dual roles of cystatin A in the immune defense of the pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 75:190-197. 12. Qin, Y., Zhang, Y., H. Ma. J. Li, S. Xiao, Z. Yu* etc., 2018, Comparison of the Biochemical Composition and Nutritional Quality nBetween Diploid and Triploid Hong Kong Oysters, Crassostrea hongkongensis. Frontiers in Physiology, 9 :1674. 13. Ma, H., L. Lin, Y. Zhang, W. Shi and Z. Yu*, 2018, The complete mitochondrial genome sequence of the giant clam Tridacna derasa (Tridacnidae: Tridacna). Mitochondrial DNA Part B. https://doi.org/10.1080 /23802359.2018. 14. Li, J., Zhang, Y., Zhang, Y., Mao F., S. Xiao, Z. Xiang, Z. Yu* et al, 2018, A Lysin motif (LysM)-containing protein from Hong Kong oyster, Crassostrea hongkongensis functions as a pattern recognition protein and an antibacterial agent. Gene, 674 :134–142. 15. Li, J., Zhang, Y., Y. Qin, Mao F., Y. Lin, Y. Zhang, Z. Yu* et al, 2018, The first morphologic and functional characterization of hemocytes in Hong Kong oyster, Crassostrea hongkongensis. Fish & Shellfish Immunology, 81:423-429. 16. Qin, Y., S. Xiao, H. Ma. J. Li, Y. Zhang*, Z. Yu* etc., 2018, Effects of salinity and temperature on the timing of germinal vesicle breakdown and polar body release in diploid and triploid Hong Kong oysters, Crassostrea hongkongensis, in relation to tetraploid induction. Aquaculture Research, DOI: 10.1111/are.13833. 17. Zhang, Y., Li, J., Zhang, Y., Ma, H., Xiao, S., Xiang, X. ans Z. Yu*, (2017) Performance evaluation of reciprocal hybrids derived from the two brackish oysters, Crassostrea hongkongensis and Crassostrea sikamea in southern China. Aquaculture 473 310-316. 18. Zhang, Y., Li, J., Qin, Y., Zhou, Y., Zhang, Y., Yu, Z*. 2017, A comparative study of the survival, growth and gonad development of the diploid and triploid Hong Kong oyster, Crassostrea hongkongensis (Lam & Morton 2003). Aquaculture Research, 48(5): 2453-2462. 19. Zhang, Y., Zhang, Y., Li, J., Wang, Z., Yan, X., Yu, Z*. 2017, Incomplete sterility of hybrids produced by Crassostrea hongkongensis female× Crassostrea gigas male crosses. Aquaculture Research, 48(3): 1351-1358. 20. Zhang, Y., Y. Zhang, J. Li, Z. Yu*, 2017, Morphological and molecular evidence of hybridization events between two congeneric oysters, Crassostrea hongkongensis and C. ariakensis , in southern China. J. Mollus. Stud. 83(1):123-128. 21. Zhang, Y., Y. Zhang, J. Li, S. Xiao, Z. Xiang, Z. Wang*, X. Yan, Z. Yu*, 2016, Artificial interspecific backcrosses between the hybrid of female Crassostrea hongkongensis × male C. gigas and the two parental species. Aquaculture, 450:95-101. 22. Zhang, Y., J. Su, J. Li, Y. Zhang, S. Xiao, Z. Yu*, 2016, Survival and growth of reciprocal crosses between two stocks of the Hong Kong oyster Crassostrea hongkongensis (Lam & Morton, 2003) in southern China. Aquaculture Research, 48:2344-2354. 23. Zhang, Y., J. Li, Y. Qin, Y. Zhou, Y. Zhang, Z. Yu*, 2016, A comparative study of the survival, growth and gonad development of the diploid and triploid Hong Kong oyster, Crassostrea hongkongensis (Lam & Morton 2003). Aquaculture Research, 48:2353-2362. 24. Li, J. , Y. Zhang, Y. Liu, Y. Zhang, S. Xiao, Z. Yu*, 2016, Co-expression of heat shock protein (HSP) 40 and HSP70 in Pinctada martensii response to thermal, low salinity and bacterial challenges. Fish Shellfish Immunol. 48: 239-243. 25. Wang, F., S. Xiao, Zhang, Y., Y. Zhang, Y. Liiu, Y. Yan, Z. Xiang, Z. Yu*, 2015, ChAkt1 involvement in orchestrating the immune and heat shock responses in Crassostrea hongkongensis: Molecular cloning and functional characterization. Fish Shellfish Immunol. 4: 1015-1023. 26. Tong, Y., Y. Zhang*, J. Huang, S. Xiao, Y. Zhang, Jun Li, J. Chen, Z. Yu*, 2015, Transcriptomics Analysis of Crassostrea hongkongensis for the Discovery of Reproduction-Related Gene. PLoS One, 10(8):e0134280. 27. Xu, F., Y. Zhang*, J. Li, Y. Zhang, Z. Xiang, Z. Yu, 2015, Expression and Function analysis of two Naturally Truncated MyD88 variants in the Pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 45:510-516. 28. Xu, F., J. Li, Y. Zhang, X. Li, Y. Zhang*, Z. Xiang, Z. Yu*, 2015, CgIκB3, the third novel inhibitor of NF-kappa B (IκB) protein, is involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 46:648-655. 29. Zhang, Y., Y. Zhang, J. Li, Z. Wang, X. Yan, Z. Yu*, 2015, Incomplete sterility of hybrids produced by Crassostrea hongkongensis female x Crassostrea gigas male crosses. Aquaculture Res. DOI: 10.1111/ are.12941 30. Qu, F., Z. Xiang, F. Wang, Y. Zhang, J. Li, Y. Zhang, S. Xiao, Z. Yu*, 2015, Identification and function of an evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) from Crassostrea hongkongensis. Develop. Comp. Immunol. 31. Zhang, Y., Y. Zhang, Li J., Z. Wang*, X. Yan, Z. Yu*, 2015, Phenotypic trait of Crassostrea hongkongensis♀× C. angulata♂ hybrids in southern China. Aquaculture Research, DOI:10.1111/are.12787. 32. Qu, , F., Z. Xiang, F. Wang, Y. Zhang, Y. Tong, J. Li, Y. Zhang, Z. Yu*, 2015, A novel molluscan Fos gene with immune defense function identified in the Hong Kong oyster, Crassostrea hongkongensis. Develop. Comp. Immunol. 51:194-201. 33. Li, J. , Y. Zhang, Y. Zhang, Y. Liu, Z. Xiang, F. Qu, Z. Yu, 2015, Cloning and characterization of three suppressors of cytokine signaling (SOCS) genes from the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 44: 525–532. 34. Qu, F., Xiang, Z., F. Wang, L. Qi, F. Xu, S. Xiao and Z. Yu*, 2015, Prostaglandin E receptor 4 (PTGER4) involved in host protection against immune challenge in oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 42: 316–324. 35. Xiang, Z., F. Qu, F. Wang, Y. Tong, S. Xiao, J. Li, Y. Zhang and Z. Yu*, 2015, ChBax/Bak as key regulators of the mitochondrial apoptotic pathway: Cloned and characterized in Crassostrea hongkongensis. Fish Shellfish Immunol. 42:225-232. 36. Zhang, Y., J. Sun , H. Mu , J. Li ,Y. Zhang , F. Xu , Z. Xiang, P Y. Qian , J. W. Qiu* and Z. Yu*, 2015, Proteomic basis of stress responses in the gills of the Pacific oyster Crassostrea gigas. J. Proteome Res. 14, 304−317. 37. Zhang, Y., Y. Zhang, Z. Wang*, X. Yan and Z. Yu*, 2014, Phenotypic trait analysis of diploid and triploid hybrids from female Crassostrea hongkongensis × male C. gigas. Aquaculture 434：307-314. 38. Qu, F., Xiang Z., Zhang Y, Li J., Zhang Y, Z. Yu*, 2014, The identification of the first molluscan Akirin2 with immune defense function in the Hong Kong oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 41: 455-465. 39. Xiang, Z., F. Qu, , J. Li, F. Wang, Y. Zhang and Z. Yu*, 2014, Characteristic and functional analysis of a ficolin-like protein from the oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 40: 514-523. 40. Li, J., Y. Zhang, Y. Zhang, Z. X.iang, Y. Tong, F. Qu and Z. Yu*, 2014, Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 40: 455-465. 41. Zhang, Y., F. Yu, J. Li, Y. Tong, Y. Zhang and Z. Yu*, 2014, The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 40: 466-471. 42. Zhang, Y., J. Li, F. Yu, Y. Tong, Y. Zhang, X. Zhi and Z. Yu*, 2014, Identification and functional characterization of SIMPL in Crassostrea gigas reveals its ancient origin and involvement in the regulation of Rel/NF-κB transcription activity. Fish Shellfish Immunol. 40: 239-244. 43. Xia, J. X. Wu, S. Xiao, Z. Yu*, 2014, Mitochondrial DNA and morphological identification of a new cupped oyster species Crassostrea dianbaiensis (Bivalvia: Ostreidae) in the South China Sea. Aquat. Living Resour. 27, 41-48. 44. Qu, , F., Xiang, Z., Z. Yu*, 2014, The first molluscan acute phase serum amyloid A (A-SAA) identified from oyster Crassostrea hongkongensis: Molecular cloning and functional characterization. Fish Shellfish Immunol. 39 (2014) 145-151. 45. Huang, J., Y. Zhang, J. Li, Z. Yu*, 2014, Development of SNP markers in Crassostrea hongkongensis based on the next-generation sequencing and high resolution melting analysis. Conservation Genet Resour. 6:559–562. 46. Xiang, Z., F. Qu, L. Qi, Y. Tong, J. Li, S. Xiao, Z. Yu*, 2014, Cloning and characterization of an apoptosis-related DNA fragmentation factor (DFF) from oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 38: 119–126. 47. Wu, X., S. Xiao, Z. Yu*, 2013, Mitochondrial DNA and morphological identification of Crassostrea zhanjiangensis sp. nov. (Bivalvia: Ostreidae): a new species in Zhanjiang, China. Aquat. Living Resour. 26(4): 273-280.

学术兼职

2015-09-24-今,世界牡蛎学会(WOS), 理事 2015-03-12-今,《Aquatic Living Receources》, 副主编 2011-04-12-今,科技部国际科技合作项目评审专家, 评审专家 2010-06-05-今,中国贝类学会, 常务理事 2008-07-08-今,中国科学院湛江海洋经济动物实验站站长, 站长 2007-10-12-今,美国甲壳贝类学会（NSA）会员 , 会员 2007-09-20-今,国家贝类产业技术研发中心<育种与繁育> 研究室岗位专家, <育种与繁育> 研究室岗位专家

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