周国春 - 南京工业大学

个人简介

教育背景 1997，9 - 2000，7 博士中国科学院上海药物研究所 1986，9 - 1989，6 硕士兰州大学化学系 1982，9 -1986，7 本科南京大学化学系工作经历 2010，3－现在, 教授、课题负责人、博士生导师南京工业大学药学院研究方向：药物化学，化学生物学 2005，3－2010，3, 研究员、课题组长 (PI)、博士生导师中国科学院广州生物医药与健康研究院研究方向：药物化学，化学生物学 2002，8 – 2005，2 Research Associate 美国爱因斯坦医学院生物化学系 2001，2 – 2002，8 博士后美国麻省理工学院 (MIT) 癌症研究中心和约翰霍普金斯大学医学院分子药理系 2000，8 - 2001，1 博士后美国乔治城大学医学中心药物发现研究部 1989，6 - 1997，8 助理工程师、工程师江苏省农药研究所

研究领域

药物化学，化学生物学

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Z Liu, W-K Law, D Wang, X Nie, D Sheng, S Song, K Guo, P Wei, P Ouyang, C-W Wong*, Guo-Chun Zhou (周国春)* “Synthesis and discovery of andrographolide derivatives as non-steroidal farnesoid X receptor (FXR) antagonists” RSC Adv., 2014, 4, 13533–13545 (*共同通讯作者) Guo-Chun Zhou (周国春)*, Fang Liu, Junting Wan, Jing Wang*, Decai Wang, Ping Wei, Pingkai Ouyang “Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells” Eur J Med Chem 2013, 70, 631-639. (共同通讯作者) Guo-Chun Zhou (周国春)*, Zhibing Weng, Xiaoxia Shao, Fang Liu, Xin Nie, Jinsong Liu, Decai Wang, Chunguang Wang, Kai Guo* “Discovery and SAR studies of methionine–proline anilides as dengue virus NS2B-NS3 protease inhibitors”, Bioorg Med Chem Lett 2013, 23, 6549–6554. (共同通讯作者) Jing Wang, Shaopeng Chen, Hao Cheng, Fangyi Yang, Junting Wan, Jian Bo, Yingxue Liu, Junyun Yang, Jinsong Liu, and Guo-Chun Zhou “Identification, Structural Properties and Chelating Capacity of Miltipolone as a Broad-spectrum Growth Inhibitor to Cancer Cells”, Eur. J. Med. Chem. 2011, 46, 1117-1121. (通讯作者) Qijun Liu, Hong Li, Shaopeng Chen, Guo-Chun Zhou “Synthesis of (3S,4R)-bengamide E”, Chin. Chem. Lett., 2011, 22, 505–507.. (通讯作者) Huimin Cheng, Lianwen Zhang, Yingxue Liu, Shaopeng Chen, Hao Cheng, Xin Lu, Zhuxia Zheng, Guo-Chun Zhou “Design, Synthesis and Discovery of 5-Hydroxyaurone Derivatives as Growth Inhibitors against HUVEC and Some Cancer Cell Lines”, Eur. J. Med. Chem., 2010, 45, 5950-5957. (通讯作者) Hong Li, Yingxue Liu, Qijun Liu, Wenhui Hu, Guo-Chun Zhou “Asymmetric Synthesis of 2-Amino-5-Hydroxy-Caprolactam Derivatives Mediated by E-Selective Olefination and Asymmetric Oxidation of Enol Ether”, Synthesis, 2010, 23, 4068-4074. (通讯作者) Fangyi Yang, Jie Wang, Hao Cheng, Junting Wan, Zhiyu Xiao, Guo-Chun Zhou “Amplification in vitro of Unknown RNAs and RNA Mixtures Based on Unique Restriction Enzyme Cleavage”, Acta Biochim Biophys Sin, 2010, 42, 873-882. (通讯作者) Xin Liu, Yingyong Ou, Shaopeng Chen, Xin Lu, Hao Cheng, Xian Jia, Decai Wang, Guo-Chun Zhou “Synthesis and inhibitory evaluation of cyclohexen-2-yl and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells”, Eur. J. Med. Chem., 2010, 45, 2147-2153. (通讯作者) Wenjuan Zhang, Jing Xu, Fang Liu, Chunfang Li, Yanling Jie, Shaopeng Chen, Zhiyuan Li, Jinsong Liu, Ling Chen, Guo-ChunZhou “Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A”, Chin J Chem, 2010, 28 (8), 1417-1423. (通讯作者) Yuan Chen, Shaopeng Chen, Xin Lu, Hao Cheng, Yingyong Ou, Huimin Cheng, Guo-Chun Zhou “Synthesis, Discovery and Preliminary SAR Study of Benzofuran Derivatives as Angiogenesis Inhibitors”, Bioorg. Med. Chem. Lett. 2009, 19, 1851-1854. (通讯作者) Zhang, L.; Yan, K.; Zhang, Y.; etal and Guochun Zhou “High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections”, Proc. Natl. Acad. Sci. USA 2007, 104, 4606–4611. Guo-Chun Zhou, Sapan L. Parikh, Peter C. Tyler, Gary B. Evans, Richard H. Furneaux, Olga V. Zubkova, Paul A. Benjes and Vern L. Schramm “Inhibitors of ADP-Ribosylating Bacterial Toxins Based on Oxacarbenium Ion Character at their Transition States ”,J Am Chem Soc. 2004, 126 (18), 5690-5698. Guochun Zhou, Chiawei Tsai, Jun O. Liu “Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis”, J Med Chem. 2003, 46 (16), 3452-3454.