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个人简介

1996-2000年先后美国德克萨斯州先后在加拿大安大略健康中心做博士后研究,2000年在美国贝勒医学院任研究科学家。2004年到中国医学科学院医学实验动物研究所任教授和人类疾病模型中心主任,北京市外专局专家。

研究领域

主要研究方向为基因工程模型

近期论文

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1. Yang Y, Guan F, Bai L, Zhang L, Liu J, Pan X, Zhang L. Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3526-8. 2. Yi W, Hu X, Chen Z, Liu L, Tian Y, Chen H, Cong YS, Yang F, Zhang L, Rudolph KL, Zhang Z, Zhao Y, Ju Z. Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood. 2015 Jul 30;126(5):620-8. 3. Ma N, Cheng H, Lu M, Liu Q, Chen X, Yin G, Zhu H, Zhang L, Meng X, Tang Y, Zhao S.Magnetic resonance imaging with superparamagnetic iron oxide fails to track the long-term fate of mesenchymal stem cells transplanted into heart.Sci Rep. 2015 Mar 12;5:9058. 4. Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z. Inhibition of Wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mTOR. Hepatology. 2015 Feb 23. 5. XiYang YB, Wang YC, Zhao Y, Ru J, Lu BT, Zhang YN, Wang NC, Hu WY, Liu J, Yang JW, Wang ZJ, Hao CG, Feng ZT, Xiao ZC, Dong W, Quan XZ, Zhang LF, Wang TH 6. Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2. Mol Neurobiol. 2015 Jan 10 7. 8. Lian H, Wang X, Wang J, Liu N, Zhang L, Lu Y, Yang Y, Zhang L. Heart-specific overexpression of (pro)renin receptor induces atrial fibrillation in mice. Int J Cardiol. 2015 Jan 29;184C:28-35. 9. Ouyang J1, Zhu X2, Chen Y1, Wei H1, Chen Q3, Chi X4, Qi B4, Zhang L5, Zhao Y6, Gao GF1, Wang G7, Chen JL. NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription. Cell Host Microbe. 2014 Nov 12;16(5):616-26. 10. Zhu L, Yang T, Li L, Sun L, Hou Y, Hu X, Zhang L, Tian H, Zhao Q, Peng J, Zhang H, Wang R, Yang Z, Zhang L, Zhao Y. TSC1 controls macrophage polarization to prevent inflammatory disease. Nat Commun. 2014 Sep 1;5:4696. 11. Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W, Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions. J Immunol. 2014 Oct 15;193(8):3860-71. 12. Lu D, Zhang L, Bao D, Lu Y, Zhang X, Liu N, Ge W, Gao X, Li H, Zhang L.Calponin1 inhibits dilated cardiomyopathy development in mice through the εPKC pathway. Int J Cardiol. 2014 Feb 25. pii: S0167-5273(14)00385-4. 13. Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, Yang T, Shi X, Guo H, Tan X, Zhang L, Wang Q, Li Z, Zhao Y. The Inhibitory Effect of IFN-γ on Protease HTRA1 Expression in Rheumatoid Arthritis. J Immunol. 2014 Jun 6. pii: 1302700. [Epub ahead of print 14. Bai L, Shi G, Zhang L, Guan F, Ma Y, Li Q, Cong YS, Zhang L Cav-1 deletion impaired hematopoietic stem cell function. Cell Death Dis. 2014 Mar 27;5:e1140. doi: 10.1038/cddis.2014.105 15. Ma Y, Shen B, Zhang X, Lu Y, Chen W, Ma J, Huang X, Zhang L. Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9。PLoS One. 2014 Mar 5;9(3):e89413. doi: 10.1371/journal.pone.0089413. 16. Metabolizable Bi2Se3 Nanoplates: Biodistribution, Toxicity, and Uses for Cancer Radiation Therapy and Imaging, advanced Functional materials 2013, DOI: 10.1002/adfm.201302312 17. Guo G1, Kang Q1, Zhu X2, Chen Q3, Wang X1, Chen Y1, Ouyang J1, Zhang L4, Tan H5, Chen R6, Huang S7, Chen JL A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA. Oncogene. 2014 May 19. doi: 10.1038/onc.2014.131. 18. Deng J, Liu X, Rong L, Ni C, Li X, Yang W, Lu Y, Yan X, Qin C, Zhang L, Qin Z. IFNγ-Responsiveness of Endothelial Cells Leads to Efficient Angiostasis in Tumors involving down-regulation of Dll4. J Pathol. 2014 Feb 24. doi: 10.1002/path.4340. 19. Chen K, Fu C, Chen C, Liu L, Ren H, Han Y, Yang J, He D, Zhou L, Yang Z, Zhang L, Jose PA, Zeng C. Role of GRK4 in the regulation of arterial AT1 receptor in hypertension. Hypertension. 2014 Feb;63(2):289-96. 20. Wang S, Yu Y, Geng S, Wang D, Zhang L, Xie X, Wu B, Li C, Xu H, Li X, Hu Y, Zhang L, Kaether C, Wang B. A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model. Alzheimers Res Ther. 2014 May 12;6(3):26.

学术兼职

中国实验动物学报副主编; 中国分子心脏病杂志编委; 中国实验动物学会理事; 北京实验动物学会常务理事; 北京老年协会理事。

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