个人简介
1998.09～2001.07北京协和医学院 临床医学专业 学士
2002.09～2006.12 北京协和医学院 肿瘤分子药理学 博士
2006.12～2007.03中国医学科学院药物研究所 助理研究员
2007.04～2009.02 美国Van Andel 研究所 博士后
2009.04～2013.08 中国医学科学院药物研究所 助理研究员
2013.09至今 中国医学科学院药物研究所 副研究员
研究领域
主要从事抗肿瘤药物的分子药理学研究及新药创制与开发。
近期论文
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1. Yan Li, Wanqi Zhou, Xiaoguang Chen. The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma . Int J Oncol. 2012; 41(6):2139-49 (2.657)
2. Yan Li，Ke Tang, Haijing Zhang, Yi Zhang, Wanqi Zhou, Xiaoguang Chen. Function of Aurora kinase A in Taxol-resistant breast cancer and its correlation with P-gp. Mol Med Report. 2011; 4 (4 ): 739-46 (0.418)
3. Sen Zhang, Yan Li, Xiaoguang Chen et al. Renal‑protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. Biomedical Reports.2013; 1: 34-40（co-first author）.
4. Yan Li, Zhong-Fa Zhang, Jindong Chen， Bin Tean The et al. VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma. Am J Transl Res 2010;2(3):296-308
5. 李燕，郝志勇，陈晓光. hPPARγ2单克隆抗体的制备与鉴定. 中国免疫学杂志. 2010;26(6):533-537.
6. 李燕，辛洪启，左明新，陈晓光. hPPARγ2高表达细胞模型的建立及与细胞恶性程度的关系. 中国新药杂志. 2010; 19(9):785-792.
7. 李燕，张文明，陈晓光. PPAR γ激动剂诱导HT-29凋亡及周期阻滞的作用. 哈尔滨商业大学学报（自然科学版）. 2009;25(3): 257-263.
8. 李燕，刘悦，陈晓光. PPAR γ激动剂罗格列酮对HT-29的生长抑制作用. 哈尔滨商业大学学报（自然科学版）. 2009;25(4):385-398.
9. 秦爱方, 李燕, 宋宏锐, 陈晓光, 金小锋, 王克, 张莉婧, 霍连超, 冯志强. 含吡啶-2-酰肼结构的索拉非尼类似物的设计、合成及其抗肿瘤活性 药学学报 2012, 47(12) 1623-1629（共同第一作者）.
10. Zhang S, Li Y, Li H, Zheng X, Chen X. Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. Biomed Rep. 2013 Jan;1(1):34-40. Epub 2012 Sep 25.
11. Qing Zhou, Yan Li, Jing Jin, Liwei Lang, Zhixiang Zhu, Weishuo Fang, Xiaoguang Chen. Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo. Biol. Pharm. Bull. 2012, 35(12), 2170-2179
12. Xiangyan Li, Yan Li, Yi Zhang, Ke Wang, Xia Yuan, Jing Jin, Yan Zhang, Zhanzhu Liu, Xiaoguang Chen. (2011) A novel bisindolymaleimide derivative (WK234) inhibits proliferation and induces apoptosis through the protein kinase C b pathway, in chronic myelogenous leukemia K562 cells. Leukemia & Lymphoma. 2011 Online on May 3
13. Jing Li, Yan Li, Zhiqiang Feng, Xiaoguang Chen. F84, a quinazoline derivative, exhibits high potent antitumor activity against human gynecologic malignancies. Investigational New Drugs, 2010, 28(2): 132
14. Jing Li, Yan Li, Zhi-qiang Feng, Xiao-guang Chen. Anti-tumor activity of a novel EGFR tyrosine kinase inhibitor against human NSCLC in vitro and in vivo. Cancer Letters. 2009,(279): 213–220.
15. 唐 克，李 燕，陈晓光多靶点抗肿瘤药物索拉菲尼的研究进展中国新药杂志. 2012, 20(24):2434-2441,
16. Jin J, Zhang Y, Li Y, Zhang H, Li H, Yuan X, Li X, Zhou W, Xu B, Zhang C, Zhang Z, Zhu L, Chen X. RNA-interference-mediated downregulation of Pin1 suppresses tumorigenicity of malignant melanoma A375 cells. Neoplasma. 2013, 60(1):92-100. doi: 10.4149/neo_2013_013.
17. Zhang S, Xin H, Li Y, Zhang D, Shi J, Yang J, Chen X.Skimmin, a coumarin from hydrangea paniculata, slows down the progression of membranous glomerulonephritis by anti-inflammatory effects and inhibiting immune complex deposion. Evid Based Complement Alternat Med. 2013;2013:819296. doi: 10.1155/2013/819296. Epub 2013 Aug 6.
18. Zhang S, Li H, Li Y, Zhang F, Liu Y, Chen X. Nicousmide normalizes renovascular pypertension in two-kidney one-clip hypertensive rats. Biomed Rep. 2013 Jan;1(1):89-92. Epub 2012 Oct 22.
19. Dan Huang, Yan ding, Yan Li, wang-Mei Luo, Zhong-Fa Zhang, John Snder, Kristin Vandenbeldt, Chao-Nan Qian, Bin Tean The. Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res. 2010, 70:1053-1062.
20. Zhouguang Hui, Maria Tretiakova, Zhongfa Zhang, Yan Li, Bin Tean Teh, Bin S Teh et al. radiosensitization by Inhibiting STAT1 in Renal Cell Carcinoma. International Journal of Radiation Oncology. 2009, 73(1): 288-295
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