个人简介
2009年7月毕业于北京协和医学院药理学专业，现于中国医学科学院药物研究所工作，先后任助理研究员、副研究员。
研究领域
主要从事神经退行性疾病和脑血管病相关靶点的确证、活性物质的发现及药物作用机理的基础性和应用性研究。
近期论文
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1. Liu R, Li JZ, Song JK, Zhou D, Huang C, Bai XY, Xie T, Zhang X, Li YJ, Wu CX, Zhang L, Li L, Zhang TT*, Du GH*. Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits. Neurobiol Aging. 2014; 35: 1275-1285.
2. Li Y, Zhou S, Li J, Sun Y, Hasimu H, Liu R*, Zhang T*. Quercetin protects human brain microvascular endothelial cells from fibrillary β-amyloid1–40-induced toxicity. Acta Pharmaceutica Sinica B, 2015; 5(1): 47–54.
3. Liu R, Li JZ, Song JK, Sun JL, Li YJ, Zhou SB, Zhang TT*, Du GH*. Pinocembrin protects human brain microvascular endothelial cells against fibrillar amyloid-β(1-40) injury by suppressing the MAPK/NF-κB inflammatory pathways. Biomed Res Int. 2014; 2014: 470393.
4. Liu R, Wu CX, Zhou D, Yang F, Tian S, Zhang L, Zhang TT, Du GH*. Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis. BMC Med. 2012; 10: 105.
5. Liu R, Zhang TT, Zhou D, Bai XY, Zhou WL, Huang C, Song JK, Meng FR, Wu CX, Li L, Du GH*. Quercetin protects against the Aβ(25-35)-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU. Neuropharmacology. 2013; 67: 419-431.
6. Zhao L, Wang JL*, Liu R*, Li XX, Li JF, Zhang L. Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer's disease mouse model. Molecules. 2013; 18(8): 9949-9965.
7. Liu R, Zhang T, Yang H, Lan X, Ying J, Du G*. The flavonoid apigenin protects brain neurovascular coupling against amyloid-β25-35-induced toxicity in mice. J Alzheimers Dis. 2011; 24(1): 85-100.
8. Liu R, Zhang L, Lan X, Li L, Zhang TT, Sun JH, Du GH*. Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor κappaB signaling pathway. Neuroscience. 2011; 176: 408-419.
9. Liu R, Zhang TT, Wu CX, Lan X, Du GH*. Targeting the neurovascular unit: development of a new model and consideration for novel strategy for Alzheimer's disease. Brain Res Bull. 2011; 86(1-2): 13-21.
10. Liu R, Meng F, Zhang L, Liu A, Qin H, Lan X, Li L, Du G*. Luteolin isolated from the medicinal plant Elsholtzia rugulosa (Labiatae) prevents copper-mediated toxicity in β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Molecules. 2011; 16(3): 2084-2096.
11. Liu R, Gao M, Qiang GF, Zhang TT, Lan X, Ying J, Du GH*. The anti-amnesic effects of luteolin against amyloid beta(25-35) peptide-induced toxicity in mice involve the protection of neurovascular unit. Neuroscience. 2009; 162(4): 1232-1243.
12. Liu R, Lan X, Ying J, Du GH*. Protective effects of luteolin against amyloid β25-35-induced toxicity on rat cerebral microvascular endothelial cells. Chin J Nat Med. 2010; 8(3): 223-227.
13. Huang ZL, Liu R, Bai XY, Zhao G, Song JK, Wu S, Du GH*. Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder. Acta Pharmacol Sin. 2014; 35: 24-32.
14. Wu CX, Liu R, Gao M, Zhao G, Wu S, Wu CF, Du GH*. Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis. Neurosci Lett. 2013; 546: 57-62.
15. Lan X, Liu R, Sun L, Zhang T, Du G*. Methyl salicylate 2-O-β-D-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes. J Neuroinflammation. 2011; 8: 98.
16. Meng F, Liu R, Gao M, Wang Y, Yu X, Xuan Z, Sun J, Yang F, Wu C, Du G*. Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats. Brain Res. 2011; 1391: 93-101.
17. Zhang D, Liu R, Sun L, Huang C, Wang C, Zhang DM, Zhang TT*, Du GH*. Anti-inflammatory activity of methyl salicylate glycosides isolated from Gaultheria yunnanensis (Franch.) Rehder. Molecules. 2011; 16(5): 3875-3884.
18. Yang Z, Liu R, Li X, Tian S, Liu Q, Du G*. Development and validation of a high-performance liquid chromatographic method for determination of pinocembrin in rat plasma: application to pharmacokinetic study. J Pharm Biomed Anal. 2009; 49(5): 1277-1281.
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