个人简介
教育背景：
1994.9 -1999.7 济宁医学院 临床医学学士
1999.9 -2002.7 天津医科大学 生理学硕士
2005.9 -2008.7 北京协和医学院 药理学博士
工作经历：
2002.7 – 2005.8 中科院电工研究所 实习研究员
2008.9 – 2011.9 中国医学科学院药物研究所 助理研究员
2011.10 – 中国医学科学院药物研究所 副研究员
研究领域
主要从事神经退行性疾病发病机制及药物新靶点的发现和新药开发研究。
近期论文
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1. Bao XQ, Kong XC, Kong LB, Wu LY, Sun H, Zhang D.Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models.Brain Res. 2013 Dec 30. doi: 10.1016/j.brainres.2013.12.026. [Epub ahead of print]
2. Ye X, Tai W, Bao X, Chen X, Zhang D.FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells.Naunyn Schmiedebergs Arch Pharmacol. 2014;387(1):75-85.
3. Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H, Zhang D.FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer's Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation. PLoS One. 2013;8(11):e78033.
4. Tai W, Ye X, Bao X, Zhao B, Wang X, Zhang D. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology. 2013; 75:201-12.
5. Bao XQ, Kong XC, Qian C, Zhang D. FLZ protects dopaminergic neuron through activating Akt/mTOR pathway and inhibiting RTP801 expression in Parkinson’s disease models. Neuroscience. 2012;202:396-404.
6. Kong XC, Zhang D, Qian C, Liu GT, Bao XQ*. FLZ, a novel HSP27 and HSP70 inducer, protects SH-SY5Y cells from apoptosis caused by MPP(+).Brain Res. 2011;1383:99-107.
7. Hou Y*, Bao XQ*, Wei HL, Luo Y, Liu GT. Long-term deprivation of gonadal hormone accelerates brain aging in mice. Neurol Res. 2011;33(1):43-9.(co-first author)
8. Bao XQ, Liu GT. The anti-hepatocyte apoptosis of bicyclol in HepG2 cells intoxicated with D-galactosamine is mediated through its induction of heat shock protein 27. Acta Pharmacol Sin. 2010; 31(2):219-226.
9. Bao XQ, Liu GT. Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by d-galactosamine. J Asian Nat Prod Res. 2010;12(4):313-23.
10. Bao XQ, Liu GT. Induction of heat shock protein 27 and 70 overexpression by bicyclol attenuates concanavalin A -induced liver injury through suppression of NF-{kappa}B in mice.Mol Pharmacol. 2009;75(5):1180-1188.
11. Bao XQ, Liu GT. Bicyclol: a novel antihepatitis drug with hepatic heat shock protein 27/70-inducing activity and cytoprotective effects in mice. Cell Stress Chaperones. 2008 Sep;13(3):347-55.
12.鲍秀琦，孔祥臣，刘耕陶. 番荔枝酰胺衍生物FLZ对自然衰老小鼠学习记忆障碍的改善作用及机制.中国新药杂志. 2010; 19(10):867-872.
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