个人简介
教育背景：
2007 – 2009 日本名古屋大学 理学研究科 化学系 博士
2005 – 2007 日本名古屋大学 理学研究科 化学系 硕士
1998 – 2002 北京大学 化学与分子工程学院 化学系 学士
工作经历：
2014 至今 中国医学科学院&北京协和医学院 药物研究所 副研究员
2009 – 2014 日本东北大学 生命科学研究科 助理教授
研究领域
1. 生物活性的复杂天然产物的全合成，特别关注具有笼状碳骨架的天然产物目标分子。
2. 有机合成策略和合成反应的开发。
3. 创新药物的研发。
近期论文
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1. Tetsuya Sengoku#, Shu Xu# (#equal contribution), Kenji Ogura, Yoshinori Emori, Kenji Kitada, Daisuke Uemura, Hirokazu Arimoto* Total synthesis of the antibiotic kendomycin: A macrocyclization using the Tsuji–Trost etherification Angew. Chem. Int. Ed. 2014, 53, 4213–4216.
2. Shu Xu#, Kaori Itto# (#equal contribution), Masahide Satoh, Hirokazu Arimoto* Unexpected dehomologation of primary alcohols to one-carbon shorter carboxylic acids using o-iodoxybenzoic acid (IBX) Chem. Commun. 2014, 50, 2758–2761.
3. Xiaolei Wang, Miho Emoto, Atsushi Sugimoto, Yusuke Miyake, Kaori Itto, Mitsuo Amasaka, Shu Xu, Hiroshi Hirata, Hirotada Fujii, Hirokazu Arimoto* Synthesis of 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging Tetrahedron Lett. 2014, 55, 2146–2149.
4. Shu Xu, Daisuke Unabara, Daisuke Uemura, Hirokazu Arimoto*Enantioselective total synthesis of pinnaic acid and halichlorine Chem. Asian J. 2014, 9, 367–375.
5. Yusuke Miyake, Xiaolei Wang, Mitsuo Amasaka, Kaori Itto, Shu Xu, Hirokazu Arimoto, Hirotada Fujii, Hiroshi Hirata* Simultaneous imaging of an enantiomer pair by electron paramagnetic resonance using isotopic nitrogen labeling Anal. Chem. 2013, 85, 985–990.
6. Jun Nakamura, Hidenori Yamashiro, Sayaka Hayashi, Mami Yamamoto, Kenji Miura, Shu Xu, Takayuki Doi, Hideki Maki, Osamu Yoshida, Hirokazu Arimoto* Elucidation of the active conformation of vancomycin dimers with antibacterial activity against vancomycin-resistant bacteria Chem. Eur. J. 2012, 18, 12681–12689.
7. Mapping of a lipoglycopeptide antibiotic binding site on Staphylococcus aureus penicillin-binding protein 2 using a vancomycin photoaffinity analogue Jun Nakamura, Ryota Ichikawa, Hidenori Yamashiro, Takafumi Takasawa, Xaolei Wang, Yasushi Kawai, Shu Xu, Hideki Maki, Hirokazu Arimoto* Med. Chem. Commun. 2012, 3, 691–695.
8. Shu Xu, Hideaki Yoshimura, Norihito Maru, Osamu Ohno, Hirokazu Arimoto*, Daisuke Uemura Pinnarine, another member of the halichlorine family. Isolation and preparation from pinnaic acid J. Nat. Prod. 2011, 74, 1323–1326.
9. Osamu Yoshida, Jun Nakamura, Hidenori Yamashiro, Kenji Miura, Sayaka Hayashi, Kosei Umetsu, Shu Xu, Hideki Maki*, Hirokazu Arimoto* New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis Med. Chem. Commun. 2011, 2, 278–282.
10. Shu Xu, Takayuki Toyama, Jun Nakamura, Hirokazu Arimoto* One-pot reductive cleavage of exo-olefin to methylene with a mild ozonolysis-Clemmensen reduction sequence Tetrahedron Lett. 2010, 51, 4534–4537.
11. Yuki Nakama, Osamu Yoshida, Masanori Yoda, Keisuke Araki, Yuri Sawada, Jun Nakamura, Shu Xu, Kenji Miura, Hideki Maki, and Hirokazu Arimoto* Discovery of a novel series of semisynthetic vancomycin derivatives effective against vancomycin-resistant bacteria J. Med. Chem. 2010, 53, 2528–2533.
12. Shu Xu, Hirokazu Arimoto*, Daisuke Uemura Asymmetric total synthesis of pinnaic acid Angew. Chem. Int. Ed. 2007, 46, 5746–5749.
13. Shu Xu, Jia Xi Xu* Mass spectrometric fragmentation of 1-(benzyloxycarbonyl)amino-2-alkyl/cycloalkyl thioacetates: a thioester pyrolysis-type rearrangement under electron impact ionization Chin. Chem. Lett. 2006, 17, 1069–1072.
14. Jiaxi Xu*, Shu Xu, Qihan Zhang The first synthesis of optically active 1-substituted taurines Heteroatom Chem. 2005, 16, 466–471.
15. Negative-ion electrospray ionization mass spectrometry of N-benzyloxycarbonyl-protected 1-substituted and cyclic taurines Jiaxi Xu*, Yuan Ma, Shu Xu, Yufen Zhao Rapid Commun. Mass Spectrom. 2005, 19, 1835–1838.
16. Jiaxi Xu*, Shu Xu A general route to the synthesis of N-protected 1-substituted and 1,2-disubstituted taurines Synthesis 2004, 276–282.
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