个人简介
1996年至2012年：中国医学科学院药物研究所合成室研究员，博士研究生导师。
1994年5月至1995年12月：美国国家健康研究院（NIH）NIDDK 研究所糖化学部访问学者，进行新型糖基抗霍乱疫苗的合成研究。
1992年5月至1994年5月：美国Virginia大学化学系进行生物活性物质糖苷磷酸肌醇酯衍生物的合成研究。
1986年至1990年12月：法国巴黎高等师范学院化学系 P.Sinay教授试验室进行糖化学合成工作，进行具有抗凝血，抗血栓活性的小分子肝素合成和构效关系究。1990年获得法国理学博士学位。
1986年至1987年于法国SANOFI集团 CHOAY 研究所Dr.M.Petitou实验室进行糖化学合成工作，主要进行具有抗凝血，抗血栓活性的小分子肝素合成研究。
1983年至1985年12月：瑞士洛桑大学药物化学系学习。同时在联邦洛桑高工暨洛桑大学有机化学研究所P. Vogel 教授试验室进行合成研究工作。
1978年至1982年：北京市科委营养源研究所合成室工作。
近期论文
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1．Xiaozhuo Chen _, Yanpeng Xu_, Zhehui Zhao, Pingsheng Le i﹡
Synthesis of several novel 14-membered ketolides bearing modified 5-O-40-[1,2, 3] triazol desosamine side chain
Tetrahedr.Lett 55 2014 6128-6130
2．Zhehui Zhao, Longlong Jin, Yanpeng Xu, Di Zhu, Yi Liu, Chao Liu, Pingsheng Lei﹡
Synthesis and antibacterial activity of a series of novel9-O-acetyl- 40-substituted 16-membered macrolides derived from josamycin
Bioorg.Med. Chem. Lett 23 2014 480-484
3．Yu-yao Guan , Chao Song , Ping-sheng Lei﹡
Synthesis of cholestane saponin as mimic of OSW-1 and PG545 to explore its cytotoxic and ntiangiogenesis activities
JANPR 2014 60(1) 43-52
4．Yanpeng Xu, Xiaozhuo Chen, Di Zhu, Yi Liu, Zhehui Zhao, LongJin, Chao Liu, Pingsheng Lei*
Synthesis and antibacterial activity of novel modified 5-O- mycaminose 14-membered ketolides
Euro.J.Med.Chem. 2013 69 174-181
5．Yu-yao Guan , Dan Zhenga, Zheng Yan , Nan Wang , Ping-sheng Lei *
Synthesis and antitumor activity of 5, 6-dihydro-17-hydroxy icogenin analogs
Euro.J.Med.Chem. 2012 51 200-205
6．Xiaozhuo Chen, Peng Xu, Yanpeng Xu, Lu Liu, Yi Liu, Di Zhu, Pingsheng Lei*
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides
Bioorg.Med.Chem.Lett. 2012 22 7402-7405
7．Haixing Wang, Yanshen Guo, Yuyao Guan, Liang Zhou, Pingsheng Lei*
Synthesis of cholestane and furostan saponin analoquew and the determination of sapogenin’s absolute configuration at C-22 Steroide 2011 76 18-27
8．Xiao-zhuo Chen, Peng Xu, Lu Liu, Pingsheng Lei*
Synthesis and antibacterial activities of novel ketolides with 11, 12-sulfur contained aryl alkyl side chains Euro.J.Med.Chem. 2011 46（1） 208-217
9．Yuyao Guan,Dan Zheng, Haixing Wang, Zheng Yan, Nan Wang, Pingsheng Lei*
Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy ang their antitumor activities Bioorg.Med.Chem.Lett 21 2921-2924 2011
10．Dan Zheng, Yuyao Guan, Xiaozhuo Chen, Yanpeng Xu, Xiaoguang Chen, Pingsheng Lei*
Synthesis of cholestane saponins as mimic of OSW-1 and their cytotoxic activities Bioorg.Med.Chem.Lett 21 3257-3260 2011
11．Dan Zheng, Yuyao Guan, Xiaozhuo Chen, Wanqi Zhou, Xiaoguang Chen,Ping-sheng Lei*
Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1-4 lingked analogue and their antitumor activuties Bioorg.Med.Chem Lett. 2010 20 5439-5442
12．Peng Xu, Xiao-zhuo Chen, Lu Liu , Zhi-ping Jin, Ping-sheng Lei*
A new series of macrolide derivatives with 4”-O-saccharide substiyuents
Bioorg.Med.Chem.Lett. 2010 20 5527-5531
13．Peng Xu, Lu Liu, Xiao-zhuo Chen, Yun Li, Jian Liu, Zhi-ping Jin, , Ping-sheng Lei*
Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity Bioorg.Med.Chem.Lett. 2009 19（15） 4079-4083
14．Haixing Wang, Fuqin Su, Liang Zhou, Xiaoguang Chen, Pingsheng Lei*
Synthesis and cytotoxicities of icogenin analogues with disaccharide residues
Bioorg.Med.Chem.Lett. 2009 19（10） 2796-2800
15．Peng Xu, Lu Liu, Zhi-ping Jin，Guang-qiang Wang,Jian Liu,Yu Li, Pingsheng Lei*
Synthesis and antibacterial activity of 4”-O-heteroarylcarbamoyl derivatives of macrolide Bioorg.Med.Chem.Lett. 2008 18 5507-5511
16．Peng Xu, Lu Liu, Zhiping Jin and Lei Ping-sheng*
Synthesis snd Antibacterial Activity of Derivatives of 6-O-allylic Acylides
Bioorg.Med.Chem.Lett. 2007 17? 3330-3334
17．Hou Shu-jie, Xu Peng, Liang Zhou, Dequan Yu, Lei Ping-sheng*,
Synthesis and Antitumor Activity of Icogenin and its Analogue
Bioorg.Med.Chem.Lett. 2006 16(9) 2454-2458
18．Zou Chuan-chun, Hou Shu-jie, Shi Yang, Lei Ping-sheng*and Liang Xiao-tian.
The synthesis of gracillin and dioscin:two typical representatives of spirostanol glycosides
Carbohydr. Res., 2003, 338: 721-727.
19．Villeneuve, S., Souchon, H., Riotto, M. M., Mazie, J. C., Lei, P. S., Glaudemans, C. P. J., Kovac, P., Fourner, J. M.,
Crystal structure of an anti-carbohydrate antibody directed against Vibrio Cholerae O:1 in complex with antigen: Molecular basis for serotype specificity Proc.Natl.Acad.Sci., 2000, (15):8433-8438
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