庾石山 - 中国医学科学院药物研究所 -

个人简介

1993年获理学博士学位，1995-1996年在奥地利维也纳大学作博士后研究。现任中国医学科学院药物研究所副所长和“天然药物活性物质与功能”国家重点实验室主任。

研究领域

1. 有毒药用植物活性成分的化学研究; 2. 中药药效物质的化学研究; 3. 高效快速新型结构活性天然产物的识别方法学研究。

近期论文

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1. Shi YS, Liu YB, Li Y, Li L, Qu J, Ma SG, Yu SS*. Chiral resolution and absolute configuration of a pair of rare racemic spirodienone sesquineolignans from Xanthium sibiricum. Org. Lett., 2014, 16, 5406-5409. 2. Li Y, Liu YB, Liu YL, Wang C, Wu LQ, Li L, Ma SG, Qu J, and Yu SS*. Mollanol A, a Diterpenoid with a New C‑Nor-D-homograyanane Skeleton from the Fruits of Rhododendron molle. Org. Lett., 2014, 16, 4320−4323. 3. Liu YB, Ding GZ, Li Y, Qu J, Ma SG, Lv HN, Liu Y, Wang WJ, Dai JG, Tang Y, Yu SS*. Structures and Absolute Configurations of Penicillactones A–C from an Endophytic Microorganism, Penicillium dangeardii Pitt. Org. Lett., 2013, 15, 5206-5209. 4. Ma SG, Gao RM, Li YH, Jiang JD, Gong NB, Li L, Lü Y, Tang WZ, Liu YB, Qu J, Lv HN, Li Y, Yu SS*. Antiviral Spirooliganones A and B with Unprecedented Skeletons from the Roots of Illicium oligandrum. Org. Lett., 2013, 15(17), 4450-4453. 5. Li Y, Liu YB, Li YH, Jiang D, Yu SS*, Ma SG, Qu J, Lv HN. Mollolide A, a Diterpenoid with a Unique 1,10:2,3-disecograyanane Skeleton from the Roots of Rhododendron molle. Org. Lett., 2013, 15 (12): 3074–3077. 6. Wang XJ, Liu YB, Li L, Yu SS*, Lv HN, Ma SG, Bao XQ, Zhang D, Qu J, Li Y. Lycojaponicumins D and E: Two New Alkaloids from Lycopodium japonicum. Org. Lett., 2012, 14(22):5688-5691. 7. Wang XJ, Zhang GJ, Zhuang PY, Zhang Y, Yu SS*, Bao XQ, Zhang D, Yuan YH, Chen NH, Ma SG, Qu J, Li Y. Lycojaponicumins A-C, Three alkaloids with an unprecedented skeleton from Lycopodium japonicum. Org. Lett., 2012, 14(10): 2614-2617. 8. Wu XF, Hu YC, Yu SS*, Jiang N, Ma J, Tan RX, Li Y, Lv HN, Liu J, Ma SG. Org. Lett., 2010, 12(10), 2390-2393. 9. Tang WB, Xie JL, Xu S, Lv HN, Lin MB, Yuan SP, Bai JY, Hou Q*, Yu SS*. Novel Nitric Oxide-Releasing Derivatives of Brusatol as Anti-Inflammatory Agents: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies. J. Med. Chem., 2014, 57, 7600−7612. 10. Du D, Yan J, Ren JH, Lv HN, Li Y, Xu S, Wang YD, Ma SG, Qu J, Tang WB, Hu ZW*, Yu SS*. Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart failure activity in vivo. J. Med. Chem., 2013, 56(1): 97-108. 11. Lv HN, Ren JH, Ma SG, Xu S, Qu J, Liu ZJ, Zhou Q, Chen XG, Yu SS*. Synthesis, biological evaluation and mechanism studies of deoxytylophorinine and its derivatives as potential anticancer agents. PLoS ONE., 2012, 7, e30342. 12. Wang YD, Zhang GJ, Qu J, Li YH, Jiang JD, Liu YB, Ma SG, Li Y, Lv HN, Yu SS*. Diterpenoids and Sesquiterpenoids from the Roots of Illicium majus. J. Nat. Prod., 2013, 76 (10), 1976–1983. 13. Qu J, Fang L, Ren XD, Liu YB, Yu SS*, Li l, Bao XQ, Zhang D, Li Y, Ma SG. Bisindole alkaloids with neural anti-inflammatory activity from Gelsemium elegans. J. Nat. Prod., 2013, 76 (12), 2203-2209. 14. Zhang Y, Liu YB, Li Y, Ma SG, Li L, Qu J, Zhang D, Chen XG, Jiang JD, Yu SS*. Sesquiterpenes and Alkaloids from the Roots of Alangium chinense. J. Nat. Prod., 2013, 76(6), 1058−1063. 15. Liu JH, Zhao N, Zhang GJ, Yu SS*, Wu LJ, Qu J, Ma SG, Chen XG, Zhang QJ, Bai J, Chen H, Fang ZF, Zhao F. Bioactive quassinoids from the seeds of Brucea javanica. J. Nat. Prod., 2012, 75, 683-688. 16. Tang WZ, Ma SG, Qu J, Yu SS*, Liu YB, Su DM, Liu J. J Nat Prod., 2011, 74, 1268-1271. 17. Chen H, Bai J, Fang ZF, Yu SS*, Ma SG, Xu S, Li Y, Qu J, Ren JH, Li Li, Si YK, Chen XG. J Nat Prod., 2011, 74(12), 2438-2445. 18. Fang L, Du D, Ding GZ, Si YK, Yu SS*, Liu Y, Wang WJ, Ma SG, Xu S, Qu J, Wang JM, Liu YX. J Nat Prod., 2010, 73(5), 818-824. 19. Wang XJ, Ding GZ, Fang L, Dai JG, Yu SS*, Wang YH, Chen XG, Ma SG, Qu J, Xu S, Du D. J Nat Prod., 2010, 73(7), 1240-1249. 20. Zhuang PY, Zhang GJ, Wang XJ, Zhang Y, Yu SS*, Ma SG, Liu YB, Qu J, Li Y, Xu S, Lv HN, Chen X, Li L, Si YK, Zhang D. Prenylated C6-C3 compounds from the roots of Illicium henryi. Phytochemistry, 2013, 86: 176-183.

学术兼职

兼SCI期刊《Journal of Asian Natural Products Research》副主编；《药学学报》等五种中文核心期刊的编委。