胡丹 - 暨南大学

个人简介

2003年6月毕业于沈阳药科大学药学日语专业，获学士学位；2003年9月-2006年6月，在沈阳药科大学药学专业学习，获硕士学位；2006年10月，获日本文部省国费留学生奖学金，赴日本东京大学留学，于2010年3月获日本东京大学先端生命科学专业博士学位；同年4月获日本学术振兴会外国人特别研究员（JSPS）奖励计划，在日本产业技术综合研究所（AIST）从事博士后研究；2012年4月起任日本产业技术综合研究所（AIST）特别研究员。2013年1月回国，在暨南大学药学院工作，被聘为副研究员。

近期论文

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1. Hu Dan, HuangHang, TatenoHiroaki,Nakakita Sin-ichi, Sato Takashi, Narimatsu Hisashi, Yao Xinsheng and Hirabayashi Jun. Engineering ofa3'-sulpho-Galbeta1-4GlcNAc-specific probe by a single amino acid substitution of a fungal galectin.Journal of Biochemistry2015,157, 197-200. 2. Hu Dan, Tateno Hiroaki and Hirabayashi Jun. Lectin Engineering, a Molecular Evolutionary Approach to Expanding the Lectin Utilities. Molecules 2015, 20, 7637-7656. 3. Hu Dan, Tateno Hiroaki and Hirabayashi Jun. Directed evolution of lectins by an improved error-prone PCR and ribosome display method. Methods in Molecular Biology 2014, 1200, 527-538. 4. Hu Dan, Tateno Hiroaki, Sato Takashi, Narimatsu Hisashi and Hirabayashi Jun. Tailoring GalNAc alpha 1-3Gal beta-specific lectins from a multi-specific fungal galectin: dramatic change of carbohydrate specificity by a single amino-acid substitution. Biochemical Journal 2013, 453, 261-270. 5. Hu Dan, Tateno Hiroaki, Kuno Atsushi, Yabe Rikio and Hirabayashi Jun. Directed Evolution of Lectins with Sugar-binding Specificity for 6-Sulfo-galactose. Journal of Biological Chemistry 2012, 287, 20313-20320. 6. Hu Dan, Kamiya Yukiko, Totani Kiichiro, Kamiya Daiki, Kawasaki Norihito, Yamaguchi Daisuke, Matsuo Ichiro, Matsumoto Naoki, Ito Yukishige, Kato Koichi and Yamamoto Kazuo. Sugar-binding activity of the MRH domain in the ER alpha-glucosidase II beta subunit is important for efficient glucose trimming. Glycobiology 2009, 19, 1127-1135. 7. Hu Dan, Man Zhiqiu, Wang Pu, Tan Xuan, Wang Xiaodong, Takaku Shizuka, Hyuga Sumiko, Sato Toshinori, Yao XinSheng, Yamagata Sadako and Yamagata Tatsuya. Ganglioside GD1a negatively regulates matrix metalloproteinase-9 expression in mouse FBJ cell lines at the transcriptional level. Connective Tissue Research 2007, 48, 198-205. 8. Hu Dan, Tan Xuan, Sato Toshinori, Yamagata Sadako and Yamagata Tatsuya. Apparent suppression of MMP-9 activity by GD1a as determined by gelatin zymography. Biochemical and Biophysical Research Communications 2006, 349, 426-431.