个人简介
学习经历:
1978.9-1983.7 华西医科大学医学院 临床医学专业 本科生
1985.9-1988.7 在华西医科大学基础医学院 攻读药理学硕士学位
1998.9–2001.7 在华西医科大学基础医学院 攻读病理生理学博士学位
海外学习经历：
1999年1月–2002年12月 在日本名古屋大学医学部进修学习
工作经历:
1977.2-1978.8 四川化工厂科研科 实验员
1983.8-2002.7 华西医科大学基础医学院药理教研室先后任助教、讲师、副教授
2002.7-今 暨南大学药学院 先后任副教授、教授、硕士生、博士生导师、药学系系主任、副院长。
近期论文
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1. Wang XX, Xu J, Wang H, Wu L, Yuan WQ, Du J, Cai SH. Trichostatin A, a histone deacetylase inhibitor, reverses epithelial–mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. Biochem. Biophys. Res. Commun:456:320-326,2015.
2. L. Wu, J. Xu, W. Yuan, B. Wu, H. Wang, G. Liu, X. Wang, J. Du and S. Cai:The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells.PLoS One:1932-6203 .2014.
3. Jun Xu ,Sichao Huang ,Tiantian Zhang ,Nong Wu ,Hongjun Kang , Shaohui Cai ,Weizai Shen:The SAR studies on FAP inhibitors as tumor-targeted agents.Med Chem Res:0888-5885.2014.
4. X.-F. Wang, H.-S. Wang, H. Wang, F. Zhang, K.-F. Wang, Q. Guo, G. Zhang, S.-H. Cai and J. Du: The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: Focus on macrophage polarization of THP-1 cells. Cellular Immunology:0008-8749,2014.
5. H. Wang, H. S. Wang, B. H. Zhou, C. L. Li, F. Zhang, X. F. Wang, G. Zhang, X. Z. Bu, S. H. Cai and J. Du:Epithelial-mesenchymal transition (EMT) induced by TNF-alpha requires AKT/GSK-3beta-mediated stabilization of snail in colorectal cancer. PLoS ONE: 1932-6203,2013.
6. G. M. Jiang, H. S. Wang, F. Zhang, K. S. Zhang, Z. C. Liu, R. Fang, H. Wang, S. H. Cai and J. Du: Histone deacetylase inhibitor induction of epithelial-mesenchymal transitions via up-regulation of Snail facilitates cancer progression. Biochimica Et Biophysica Acta-Molecular Cell Research: 0167-4889,2013.
7. R. Fang, G. Zhang, Q. Guo, F. Ning, H. Wang, S. Cai and J. Du : Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma. Cancer letters: 1872-7980,2013.
8. Y. Deng, P. Gao, C. Guo, L. Wu, J. Xu, H. Chen and S.-h. Cai: Z-GP Modification to CI-994, a Histone Deacetylase Inhibitor and the Application in Target-ing Carcinoma Chemotherapy. Medicinal Chemistry :1573-4064,2013.
9. H. Liu, B. H. Zhou, X. Qiu, H. S. Wang, F. Zhang, R. Fang, X. F. Wang, S. H. Cai, J. Du and X. Z. Bu: T63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-FOXO3a pathway in lung cancer cells. Free Radical Biology and Medicine: 0891-5849,2012.
10. Huang S, Fang R, Xu J, Qiu S, Zhang H, Du J, Cai S: Evaluation of the tumor targeting of a FAP alpha-based doxorubicin prodrug. J Drug Target:19(7):487-496,2011
11. Y. M. Yi, G. Zhang, J. Zeng, S. C. Huang, L. L. Li, R. Fang, G. M. Jiang, X. Z. Bu, S. H. Cai and J. Du:A new tumor vaccine FAP tau-MT elicits effective antitumor response by targeting indolamine-2,3-dioxygenase in antigen presenting cells.Cancer Biology & Therapy:1538-4047,2011.
12. J. Xu, Y. J. Lu, W. Z. Shen, H. B. Luo, S. C. Huang, J. L. Bao, S. H. Cai and Y. Q. Wang: Homology Modeling of alpha-Glucosidase and its Interactions with Andrograpolide Derivatives.Letters in Drug Design & Discovery:1570-1808,2011.
13. G. M. Jiang, Y. W. He, R. Fang, G. Zhang, J. Zeng, Y. M. Yi, S. Zhang, X. Z. Bu, S. H. Cai and J. Du: Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels.International Journal of Biochemistry & Cell Biology:1357-2725,2010.
14. Y. B. Yang, S. X. Cai, L. Yang, S. H. Yu, J. H. Jiang, X. Q. Yan, H. X. Zhang, L. Liu, Q. Liu, J. Du, S. H. Cai and K. L. P. Sung:Targeting eradication of malignant cells derived from human bone marrow mesenchymal stromal cells.Experimental Cell Research:0014-4827,2010.
15. J. Xu, S. C. Huang, H. B. Luo, G. J. Li, J. L. Bao, S. H. Cai and Y. Q. Wang:QSAR Studies on Andrographolide Derivatives as alpha-Glucosidase Inhibitors.International Journal of Molecular Sciences:1422-0067,2010.
16. S. C. Huang, R. Fang, J. Xu, S. H. Qiu, H. Zhang, J. Du and S. H. Cai: Evaluation of the tumor targeting of a FAP alpha-base d doxorubicin prodrug.Journal of Drug Targeting:1061-186X,2010.
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