楊嘉鈴 - 台湾清华大学

个人简介

學歷一覽密西根州立大學美國生物化學博士 1983年09月 ~ 1988年中興大學中華民國土壤學系學士 1975年09月 ~ 1979年06月經歷一覽國立清華大學教授生物科技所教授 2002年08月 ~ 國立清華大學教授生命科學系教授 1996年08月 ~ 國立清華大學副教授生物醫學所副教授 1991年08月 ~ 1996年07月中央研究院博士後研究生物醫學所博士後研究 1989年02月 ~ 1991年07月密西根州立大學博士後研究癌病學研究室博士後研究 1988年01月 ~ 1989年01月

研究领域

分子癌病、基因毒理、核酸修補、分子生物學

近期论文

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2010 Yen, A.H. and Yang, J.L.* ,2010,Cdc20 Proteolysis Requires p38 MAPK Signaling and Cdh1-Independent APC/C Ubiquitination During Spindle Assembly Checkpoint Activation by Cadmium, Journal of Cellular Physiology ,223,2,pp327-334 (SCI) 楊嘉鈴 2009 Wang, C.Y., Wang, Y.T., Tzeng, D.W. and Yang, J.L.* ,2009,Lead acetate induces EGFR activation upstream of SFK and PKC alpha linkage to the Ras/Raf-1/ERK signaling,Toxicology and Applied Pharmacology,235,2,pp244-252 (SCI) 楊嘉鈴 2008 Wang, C.Y., Lin, Y.W. and Yang, J.L.* ,2008,Activation of protein kinase C alpha signaling prevents cytotoxicity and mutagenicity following lead acetate in CL3 human lung cancer cells,Toxicology,250,1,pp55-61 (SCI) 楊嘉鈴 2008 Li, J.P., Wang, C.Y., Tang, Y.A., Lin, Y.W. and Yang, J.L.* ,2008,Role of extracellular signal-regulated kinase (ERK) signaling in nucleotide excision repair and genotoxicity in response to As(III) and Pb(II),Pure and Applied Chemistry ,80,12,pp2735-2750 (SCI) 楊嘉鈴 2007 Li, J.P. and Yang, J.L.*,2007,Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite,Journal of Cellular Physiology ,212,2,pp481-488 (SCI) 楊嘉鈴 2006 Lin, Y.W. and Yang, J.L.* ,2006,Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive-feedback regulation of proliferating signaling,Journal of Biological Chemistry,281,2,pp915-926 (SCI) 楊嘉鈴 2006 Li, J.P., Lin, J.C. and Yang, J.L.*,2006,ERK activation in arsenite-treated G1-enriched CL3 cells contributes to survival, DNA repair inhibition, and micronucleus formation,Toxicological Sciences,89,1,pp164-172 (SCI) 楊嘉鈴 2006 Hsiue, G.H., Wang, C.H., Lo, C.L., Li, J.P. and Yang, J.L. ,2006,Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery,International Journal of Pharmaceutics,317,1,pp69-75 (SCI) 楊嘉鈴 2004 2004,Ko JC, WangYT, and Yang JL* (2004) Dual and opposing roles of ERK in regulating G1 and S-G2/M delays in A549 cells caused by hyperoxia. Exp Cell Res 297: 472-483 , 楊嘉鈴 2003 2003,Lin YW, Chuang SM, Yang JL* (2003) ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway. J Biol Chem 278: 21534-21541 , 楊嘉鈴 2003 2003,Lin YW, Chuang SM, Yang JL* (2003)Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity. Carcinogenesis 24: 53-61 , 楊嘉鈴 2003 2003,Chuang SM, Wang IC, Hwua YS,Yang JL* (2003) Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases. Carcinogenesis 24: 7-15 , 楊嘉鈴 2001 2001,Yang JL*, Chuang SM(2001) Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells.Mol Cell Biochem 222: 85-95 , 楊嘉鈴 2001 2001,Chao JI, Yang JL* (2001) Alteration of cadmium-induced mutational spectrum by catalase depletion in Chinese hamster ovary-K1 cells. Mutat. Res.498: 7-18 , 楊嘉鈴 2001 2001,Chao JI, Yang JL* (2001) Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chem. Res. Toxicol. 14: 1193-1202 , 楊嘉鈴 2000 2000,Chuang SM, Liou GY, Yang JL* (2000) Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity. Carcinogenesis 21: 1491-1500 , 楊嘉鈴 2000 2000,Chuang SM, Wang IC, Yang JL* (2000) Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis 21: 1423-1432. , 楊嘉鈴