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个人简介

教育背景 2003-09--2009-01 大连化学物理研究所 博士 1999-09--2003-06 大连理工大学 学士 专利与奖励 1. 食品中化学有害物代谢机理与控制技术研究,中国分析测试协会科学技术奖一等奖(2013-1-008-02) 2. 人参皂甙对尿苷二磷酸葡萄糖醛酸转移酶的结构-抑制作用之间关系的研究。辽宁省自然科学学术成果壹等奖 (2013-LNL1670) 3. 紫杉烷类化合物的定量结构-保留关系模型及其在紫杉烷立体异构体及位置异构体鉴别中的应用。辽宁省自然科学学术成果贰等奖 (2011-LNL0701) 4. 人细胞色素P450 3A4酶的高选择性探针底物及其应用。辽宁省自然科学学术成果叁等奖(2014-LNL0008) 5. Chinese Young Scientist Travel Award, The 18th Microsomes and Drug Oxidation (MDO) Meeting, Beijing, China (May 16-20, 2010) 6. 大连市青年科技之星(2015年)

研究领域

1. 药物筛选与评价新技术研究 2. 蛋白特异性功能探针研发及其应用基础研究 3. 外源物与代谢酶相互作用研究

近期论文

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Lv X, Wang XX, Hou J, Fang ZZ, Wu JJ, Liu SW, Cao YF, Ge GB*, Yang L*. Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-Glucuronosyltransferases. Toxicology and Applied Pharmacology 2016; 301: 42-9. (*corresponding author) Jin Q, Feng L, Wang DD; Wu JJ, Hou J, Dai ZR, Wang JY, Ge GB*, Cui JN*, Yang L*. A highly selective near-infrared fluorescent probe for carboxylesterase 2 and its bioimaging applications in living cells and animals. Biosensors & Bioelectronics, 2016; 83:193-9. (*corresponding author) Wang YR, Feng L, Xu L, Li Y, Wang DD, Hou J, Zhou K, Jin Q, Ge GB*, Cui JN*, Yang L*. A rapid-response fluorescent probe for sensitive and selective detection of human albumin in plasma and cell culture supernatants. Chem. Commun. 2016; 52:6064-7. Advance Article. (*corresponding author) Qian XK, Wang P, Xia YL, Dou TY, Ge GB*, Mi XL*, Yang L*. A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors & Actuators B. Chemical 2016; 231: 615–23. (*corresponding author) Wang DD, Jin Q, Zou LW, Hou J, Lv X, Lei W, Cheng HL, Ge GB*, Yang L*. A bioluminescent sensor for highly selective and sensitive detection of human carboxylesterase 1 in complex biological samples. Chem. Comm. 2016; 52: 3183-6. (*corresponding author) Dai ZR, Ge GB#, Feng L, Ning J, Hu LH, Jin Q, Lv X, Cui JN*, Yang L*. A highly selective ratiometric two-photon fluorescent probe for human cytochrome P450 1A. J. Am. Chem. Soc., 2015, 137 (45): 14488–95. (#contributed equally) Jin Q, Feng L, Wang DD, Dai ZR, Wang P, Zou LW, Liu ZH, Wang JY, Yu Y, Ge GB*, Cui JN*, Yang L*. A two-photon ratiometric fluorescent probe for imaging carboxylesterase 2 in living cells and tissues. ACS Applied Materials & Interfaces, 2015, 7: 28474–81. (*corresponding author) Feng L, Liu ZM, Hou J, Lv X, Ning J, Ge GB*, Cui JN*, Yang L*. A highly selective fluorescent ESIPT probe for the detection of Human carboxylesterase 2 and its biological applications. Biosensors & Bioelectronics, 2015; 65: 9-15 (*corresponding author) Lv X, Ge GB#, Feng L, Troberg J, Hu LH, Hou J, Cheng HL, Wang P, Liu ZM, Finel M, Cui JN*, Yang L*. An optimized ratiometric fluorescent probe for sensing human UDP-glucuronosyltransferase 1A1 and its biological applications. Biosensors & Bioelectronics, 2015; 72: 261-7. (#contributed equally) Lv X, Wang DD, Feng L, Wang P, Zou LW, Hao DC, Hou J*,Cui JN, Ge GB*, Yang L*. A highly selective marker reaction for measuring the activity of human carboxylesterase 1 in complex biological samples. RSC Adv., 2016, 6, 4302-9. (*corresponding author) Cui P, Dou TY, Sun YP, Li SY, Feng L, Zou LW, Wang P, Hao DC, Ge GB*, Yang L*. Efficient enzymatic preparation of Esculentoside B following condition optimization by response surface methodology. Journal of Molecular Catalysis B: Enzymatic 2016; 130:25–31 Zhu LL, Xiao L, Li W, Zhang Y, Han W, Zhu Y, Ge GB*, Yang L. Human UDP-Glucuronosyltransferases 1A1, 1A3, 1A9, 2B4 and 2B7 are inhibited by Diethylstilbesterol. Basic and Clinical Pharmacology & Toxicology, 2016; doi: 10.1111/bcpt.12618. Cui P, Dou TY, Li SY, Lu JX, Zou LW, Wang P, Sun YP, Hao DC, Ge GB*. Highly selective and efficient biotransformation of linarin to produce tilianin by naringinase. Biotechnology Letters, 2016; 38(8), 1367-73. Zou LW, Li YG, Wang P, Zhou K, Hou J, Jin Q, Hao DC, Ge GB*, Yang L*. Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2. Eur. J. Med. Chem. 2016; 112: 280-8. (*corresponding author) Xin H, Qi XY, Wu JJ, Wang XX, Li Y, Hong JY, He W, Xu W, Ge GB*, Yang L. Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases. Food and Chemical Toxicology, 2016; 90: 112-22. (*corresponding author) Wang P, Xia YL, Yu Y, Lu JX, Zou LW, Feng L,Ge GB*, Yang L*. Design, synthesis and biological evaluation of esculetin derivatives as anti-tumour agents. RSC Adv., 2015, 5: 53477-83. (*corresponding author) Feng L, Liu ZM, Xu L, Lv X, Ning J, Hou J, Ge GB*, Cui JN*, Yang L*. A highly selective long-wavelength fluorescent probe for human carboxylesterase 2 and its biomedical applications. Chem. Comm. 2014; 50 (93), 14519-22 (*corresponding author) Wang XX, Lv X, Li SY, Hou J, Ning J, Wang JY, Cao YF, Ge GB*, Guo B, Yang L. Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi). Toxicology and Applied Pharmacology 2015, 289: 70-8. (*corresponding author) Tian XG, Wang C, Ge GB#, Ai CZ, Ning J, Ai C, Hong J, Cai YX, Huo X, Hou J, et al. A highly selective probe for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human microsomes: isoform specificity, kinetic characterization, and applications. RSC Adv. 2015, 5: 5924-7. (#contributed equally) Zhu LL, Xiao L, Xia Y, Zhou K, Wang H, Huang M, Ge GB*, et al. Diethylstilbestrol can effectively accelerate estradiol-17-O-glucuronidation, while potently inhibiting estradiol-3-O-glucuronidation. Toxicology and Applied Pharmacology, 2015, 283: 109-16. (*corresponding author) He W, Wu JJ, Ning J, Hou J, Xin H, He YQ, Ge GB*, Xu W*. Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice. Toxicology in Vitro, 2015, 29:1569-76. (*corresponding author) Li YG, Hou J, Li SY, Lv X, Ning J, Ge GB*, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia, 2015; 101:99-106. (*corresponding author) Liu ZM, Feng L, Ge GB#, Lv X, Hou J, Cao YF, Cui JN, Yang L. A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase1. Biosensors & Bioelectronics, 2014; 57:30-5. (#contributed equally) Liu XD, Hu LH, Ge GB#, et al. Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay. Proteomics. 2014, 14(16):1943-51. (#contributed equally) Ge GB, Ning J, Hu LH, Dai ZR, Hou J, Cao YF, Yun ZW, Ai CZ, Ma XC*, Yang L*. A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications. Chem. Commun. 2013; 49: 9779-81. Liu ZM, Feng L, Hou J, Lv X, Ning J, Ge GB*, et al. A ratiometric fluorescent sensor for highly selective detection of human carboxylesterase 2 and its application in living cells. Sensors and Actuators B: Chemical, 2014; 205: 151-7. (*corresponding author) Ge GB, Ai CZ, Hu WB, et al. The role of serum albumin in the metabolism of Boc5: molecular identification, species differences and contribution to plasma metabolism. Eur. J. Pharm. Sci. 2013; 48: 360–9. Ning J, Hou J, Wang P, Wu JJ, Dai ZY, Zou LW, Li W, Ge GB*, et al. Interspecies Variation in Phase I Metabolism of Bufalin in Hepatic Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and Human. Xenobiotica. 2015; 45(11):954-60 (*corresponding author) Xia YL, Liang SC, Zhu LL, Ge GB*, et al. Identification and Characterization of Human UDP-Glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin. Drug Metab Pharmacokinet. 2014; 29(2):135-40. (*corresponding author) Ge GB, Zhang R, Ai CZ, Zhang YY, et al. Stereochemical differentiation of C-7 hydroxyl taxane isomers by electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2009; 23(3): 425-32. He GY, Zhang SX, Xu L, Wang P, He YQ, Ge GB*, Yang L. C-8 Mannich base derivatives of baicalein displayed improved glucuronidation stability: explore the mechanism by experiment and theoretical calculation. RSC Advances, 2015, 5: 89818 – 26. (*corresponding author) LV X, Hou J, Xia YL, Ning J, He GY, Wang P, Ge GB*, Xiu ZL, Yang L. Glucuronidation of bavachinin by human tissues and expressed UGT enzymes: identification of UGT1A1 and UGT1A8 as the major contributing enzymes. Drug Metabolism and Pharmacokinetics. 2015, 30: 358-65.(*corresponding author) Ge GB, Luan HW, Zhang YY, He YQ, et al. Profiling of yew hair roots from various species using ultra-performance liquid chromatography-electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2008; 22(15): 2315-23. Ge GB, Zhang YY, Hao DC, Hu Y, et al. Chemotaxonomic study of medicinal Taxus species with fingerprint and multivariate analysis. Planta Medica, 2008; 74(7): 773-9. Zhu LL#, Ge GB#, He GY, Liang SC, et al. Potent and Selective Inhibition of Magnolol on Catalytic Activities of UGT1A7 and 1A9. Xenobiotica, 2012; 42(10):1001-8. (#contributed equally) Liang SC#, Ge GB#, Liu HX, Shang HT, et al. Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS. J. Pharm. Biomed. Anal. 2011, 54(1):236-41. (#contributed equally) Wang AX#, Ge GB#, Qi XY, Hu Y, et al. Rapid Profiling and Target Analysis of Principal Components in Fuling Decoctions by UFLC-DAD-ESI-MS. Fitoterapia, 2010; 81: 662-7. (#contributed equally) Ge GB, Liang SC, Hu Y, Liu XB, et al. Rapid Qualitative and Quantitative Determination of Seven Valuable Taxanes from Various Taxus Species by UFLC-ESI-MS and UFLC-DAD. Planta Medica. 2010; 76(15):1773-7. Sun DX, Zhu LL, Xiao L, Xia YL, Ge GB* et al, In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences. Xenobiotica. 2014; 44(11):988-95 (*corresponding author) Hou J, Shi Q, Cao M, Pan P, Fan X, Bai G, Xin Y, Ge GB*. A Novel Approach for Fluorescent Visualization of Glycyrrhetic Acid on Cell with Quantum Dot. Biochemistry (Moscow) 2014; 79(1):25-30. (*corresponding author)

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