个人简介

教育经历： Ph.D.博士学位 专业: 有机化学; 研究方向: 不对称催化 导师：冯小明教授 B.S.学士学位 专业: 应用化学 导师：冯小明教授 研究和工作经历： 2014年9月 – 2015年4月: 研究助理教授 美国纽约州立大学水牛城分校 合作导师： Dr. Qing Lin 2009年8月 – 2014年8月: 生物化学研究助理，博士后研究助理，美国纽约州立大学水牛城分校 合作导师： Dr. Qing Lin[1] 获得的荣誉： 2008 宝钢教育奖,宝钢优秀学生特等奖 2008-2009 四川大学创新人才一等奖 2007-2008 四川大学创新人才一等奖 2007-2008 四川大学优秀博士二等奖学金 2004-2005 四川大学优秀硕士研究生二等奖学金 2002 四川大学第四届学生科技节动画设计二等奖

研究领域

有机化学

在“光点击”化学反应中，利用两个高度环张力环融合在一起的策略，设计并合成了两代环丙烯亲偶极体，并且将其用到“光点击”生物正交化学反应中，提高10倍以上的反应动力学活性。利用其高活性且稳定的性质，首次合成ε-Sph赖氨酸衍生物，并将其用于基因编载重组蛋白质表达。实现超快速反应动力学并实现蛋白质残基的特定标记。这一系列的研究，在推进“光点击”生物正交反应在活体动物中的靶标分子的跟踪和操控研究项目中起到了中流砥柱承前启后的作用。

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Linmeng Zhang , Xiaocui Zhang , Zhuojun Yao , Shichao Jiang , Jiajie Deng , Bo Li , and Zhipeng Yu *, titled "Discovery of Fluorogenic Diarylsydnone-Alkene Photoligation: Conversion of ortho-Dual-Twisted Diarylsydnones into Planar Pyrazolines" J. Am. Chem. Soc., 2018, 140 (24), pp 7390–7394. Carlo P. Ramil, Maoqing Dong, Peng An, Tracey M. Lewandowski, Zhipeng Yu, Laurence J. Miller,* and Qing Lin ,* titled " Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells " J. Am. Chem. Soc., 2017 , 139, 13376–13386. Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu,* and Qing Lin*, titled "Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking " J. Am. Chem. Soc., 2017, 139, 6078–6081. Carlo P. Ramil, Peng An, Zhipeng Yu , and Qing Lin*, tiltled "Sequence-specific 2-cyanobenzothiazole ligation " J. Am. Chem. Soc., J. Am. Chem. Soc., 2016 , 138, 5499–5502 . Zhipeng Yu and Qing Lin*, titled "Design of Spiro[2.3]hex-1-ene, a Genetically Encodable Double-Strained Alkene for Superfast Photoclick Chemistry" J. Am. Chem. Soc., 2014, 136, 4153–4156. Zhipeng Yu, Tymish Y. Ohulchanskyy, Peng An, Paras N. Prasad, and Qing Lin*, titled "Fluorogenic, Two-Photon-Triggered Photoclick Chemistry in Live Mammalian Cells" J. Am. Chem. Soc., 2013, 135, 16766–16769. Abstract Image Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang,* Qing Lin*, titled "Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells" Angew. Chem. Int. Ed.2012, 51, 10600-10604. Zhipeng Yu, Lok Yin Ho, and Qing Lin*, titled "Rapid, Photoactivatable Turn-On Fluorescent Probes Based on an Intramolecular Photo click Reaction" J. Am. Chem. Soc., 2011, 133, 11912–11915. Zhipeng Yu, Lok Yin Ho, Zhiyong Wang, Qing Lin*, titled "Discovery of new photoactivatable diaryltetrazoles for photoclick chemistry via ‘scaffold hopping’" Bioorg. Med. Chem. Lett., 2011, 21, 5033-5036. Zhipeng Yu, Reyna K. V. Lim, Qing Lin*, titled "Synthesis of Macrocyclic Tetrazoles for Rapid Photoinduced Bioorthogonal 1,3-Dipolar Cycloaddition Reactions" Chem. Eur. J. 2010, 16, 13325-13329 Thumbnail image of graphical abstract Peng An, Zhipeng Yu and Qing Lin*, titled "Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells" Chem. Commun., 2013,49, 9920-9922. Peng An, Zhipeng Yu and Qing Lin*, titled "Design and Synthesis of Laser-Activatable Tetrazoles for a Fast and Fluorogenic Red-Emitting 1,3-Dipolar Cycloaddition Reaction" Org. Lett., 2013, 15, 5496–5499. Jiangyun Wang, Wei Zhang, Wenjiao Song, Yizhong Wang, Zhipeng Yu, Jiasong Li, Minhao Wu, Lin Wang, Jianye Zang, and Qing Lin*, titled "A Biosynthetic Route to Photoclick Chemistry on Proteins" J. Am. Chem. Soc., 2010, 132, 14812–14818. Wenjiao Song, Yizhong Wang, Zhipeng Yu, Claudia I. Rivera Vera, Jun Qu, and Qing Lin*, titled "A Metabolic Alkene Reporter for Spatiotemporally Controlled Imaging of Newly Synthesized Proteins in Mammalian Cells" ACS Chem. Biol., 2010, 5, 875–885 (Cover Article). Wenjiao Song, Zhipeng Yu, Michael M. Madden and Qing Lin*, titled "A bioorthogonal chemistry strategy for probing protein lipidation in live cells" Mol. BioSyst., 2010, 6, 1576-1578 . Zhipeng Yu, Xiaohua Liu, Lin Zhou, Lili Lin, Xiaoming Feng*, titled "Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids" Angew. Chem. Int. Ed. 2009, 48, 5195-5198. Shao-Liang Zheng, Yizhong Wang, Zhipeng Yu, Qing Lin*, and Philip Coppens*, titled "Direct Observation of a Photoinduced Nonstabilized Nitrile Imine Structure in the Solid State" J. Am. Chem. Soc. 2009, 131, 18036-18037. Zhipeng Yu, Xiaohua Liu, Zhenhua Dong, Mingsheng Xie, and Xiaoming Feng*, titled "An N,N’-Dioxide/In(OTf)3 Catalyst for the Asymmetric Hetero-Diels-Alder Reaction Between Danishefsky’s Dienes and Aldehydes: Application in the Total Synthesis of Triketide". Angew. Chem. Int. Ed. 2008, 47, 1308-1311. Bo Gao, Zhipeng Yu, Zhengyan Fu and Xiaoming Feng*, titled "A Convenient and Versatile Approach to 2,3-dihydro-4H-pyran-4-ones via Tandem Aldol Reaction-conjugate Addition", Tetrahedron Letters. 2006, 47, 1537-1539. Bo Gao, Zhengyan Fu, Zhipeng Yu, Lan Yu, Yaozong Huang and Xiaoming Feng*, titled "Highly enantioselective hetero-Diels–Alder reaction between trans-1-methoxy-2-methyl-3-trimethyl-siloxybuta-1,3-diene and aldehydes catalyzed by (R)- BINOL-Ti(IV) complex", Tetrahedron. 2005, 61, 5822-5830.