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个人简介

指導學生 王鳴易 / 劉倉豪 / 林修兆 / 洪鼎惟 / 林世傑 / 呂居勳 / 蘇子誠 / 李俐瑩 / 鄭庭璞 專利 Stroma-free, serum-free and chemically defined medium and method for ex vivo mononuclear cell expansion using the same 7,723,106 B2, 2010 U.S. Hwang, S.M., Yao, C.L., Hsieh, Z.B., Chu, I.M 包覆紫杉醇之油水乳化液劑型 第127765號 中華民國 王姿容, 朱一民 Preparation of Liquid-Core Microcapsules for Cell Cultures 5,585,183 USA 朱一民 包覆紫杉醇之油水乳化液劑型 6,348,491 USA 王姿容,朱一民 一種細胞培養用液化核心包囊之改良製法 第66532號 中華民國 朱一民 擷抗層析電泳裝置及方法 第127669號 中華民國 楊宗樺,朱一民 紫杉醇乳化液之配方及其製造方法 第160991號 中華民國 朱一民,甘霈, 陳志賓 細胞培養用之液核心微包囊及其製造方法 第2678413號 日本 朱一民 利用微列生物晶片資料與生物資料庫建構動態網路關係之方法 第I-320148 中華民國發明專利 潘冠宇, 詹鎮熊, 李盛安, 朱一民, 高成炎 含醣胺素之軟骨組織架構材料及其製作方法 第1265035號 中華民國發明專利 朱一民, 柯智升, 吳俊賢 學歷 美國 萊斯大學 化學工程 博士 ~ 1984.07 台灣 國立台灣大學 化學工程學系 學士 1974.09 ~ 1978.07 經歷 國立清華大學 化學工程學系 教授 1993.08 ~ 2009.02 國立清華大學 化學工程學系 副教授 1986.08 ~ 1993.07 美國萊斯大學 化學工程系 1985.06 ~ 1986.06

研究领域

■動物細胞培養 ■幹細胞培養及應用 ■微脂粒釋藥系統 ■聚酸酐材料之生醫應用

生物技術

近期论文

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2013 Tsao, C.K., Ko, C.Y., Yang, S.R., Yang, C.Y., Brey, E.M., Huang, S., Chu, I.M., Cheng, M.H., “An ectopic approach for engineering a vascularized tracheal substitute”, Biomaterials, Accepted (2013) 2013 Hong, D.W., Lai, P.L., Ku, K.L., Lai, Z.T., Chu, I.M*.,”Novel thermosensitive hydrogels based on methoxy polyethylene glycol-co-poly(lactic acid-co-aromatic anhydride) for cefazolin delivery”, Nanomed. Accepted ( 2013) 2013 Lin, P.Y., Chu, I.M., Hwang, S.M.* “A synthetic peptide-acrylate surface for production of an insulin-producing cells from human embryonic stem cells", Stem Cell. Develop. Accepted (2013) 2013 Shih, M.C., Tseng, S.H., Weng, Y.S., Chu, I.M., Liu, C.H*. “A microfluidic device mimicking acinar concentration gradients across the liver acinus”, Biomed. Microdevice., 767-780 (2013) 2013 Hong, D.W., Lai, P.L., Ku, K.L., Lai, Z.T., Chu, I.M*., “Biodegradable in situ gel-forming controlled vancomycin delivery system based on a thermosensitive mPEG-PLCPPA hydrogel “, Polym. Degrad. Stab. 98, 1578-1585 (2013) 2013 Lin, P.Y., Yang YC, Hung SH, Lee SY, Chu, I.M., Hwang, S.M*. “Cryopreservation of human embryonic stem cells by a programmed freezer with an oscillating magnetic field”, Cryobiology, 66, 256-260 (2013) 2013 Peng, S., Yang, S.R., Peng, Y.S., Chu, I.M.*, “Evaluation of a mPEG-polyester-based hydrogel as cell carrier for chondrocytes”, J. Biomed. Mat. Res. A, 101, 3311-3319 (2013) 2013 Peng, S., Yang, S.R., Peng, Y.S., Chu, I.M.*, “Evaluation of a mPEG-polyester-based hydrogel as cell carrier for chondrocytes”, J. Biomed. Mat. Res. A, 101, 3311-3319 (2013) 2013 Shih, M.C., Tseng, S.H., Weng, Y.S., Chu, I.M., Liu, C.H*. “A gel-free multi-well micro-fluidic device utilizing surface tension for cell culturing”, Sensor. Actuator. B, 177, 295-307 (2013) 2013 Lai, P.L., Lin, C.T.Y., Hong, D.W., Chang, Y.H., Chen, L.H., Chen, W.J., Chu, I.M.* “Development of bioactive thermosensitive polymer-ceramic composite as bone substitute”, Chem. Eng. Sci., 89, 133–141 (2013) 2013 Lai, P.L., Hong, D.W., Chu, I.M*. “The influences of polycaprolactone-grafted nano-particles on the properties of polycaprolactone composites with enhanced osteo-conductivity”, Composite Sci. Technol. 83, 64-71(2013) 2013 Ko, C.Y., Ku, K.L., Yang, S.R., Lin, T.Y., Peng, S., Peng, Y.S., Cheng, M.H., Chu, I.M*., “In vitro and in vivo co-culture of chondrocytes and bone marrow stem cells in photo-crosslinked PCL–PEG–PCL hydrogels enhances cartilage formation”, J. Tissue. Eng. Regen. Med. Accepted (2013) 2013 Chiang, P.R., Lin, T.Y., Tsai, H.C., Chen, H.L., Liu, S.Y., Chen, F.R., Hwang, Y.S., Chu, I.M*.,”Thermosensitive hydrogel from oligopeptide-containing amphiphilic block copolymer: effect of peptide functional group on self-assembly and gelation behavior “, Langmuir, 51, 15981-15991(2013) 2013 Ko, C.Y., Ku, K.L., Yang, S.R., Lin, T.Y., Peng, S., Peng, Y.S., Cheng, M.H., Chu, I.M.*, “Cartilage formation through alterations of amphiphilicity of poly (ethylene glycol)-poly(caprolactone) copolymer hydrogels", RCS Adv., 3, 25769-25779 (2013) 2013 Huang, J.J., Yang, S.R., Chu, I.M., Brey, E.M., Hsiao, H.Y., Cheng, M.H. “A comparative study of the chondrogenic potential between synthetic and natural scaffolds in an in vivo bioreactor”, Sci. Technol. Adv. Mater. 14, 054403 (2013) 2013 Hwang Y.S, Chiang P.R, Hong W.H, Chiao C.C, Chu I.M,, Hsiue, G.H., Shen, C.R*., ”Study in vivo intraocular biocompatibility of in situ gelation hydrogels: poly(2-ethyl oxazoline)-block-poly(ε-caprolactone)-block-poly(2-ethyl oxazoline) copolymer, matrigel and pluronic F127”. PLoS ONE 8(7): e67495. doi:10.1371/journal.pone.0067495 (2013) 2013 Chen, W.C. Wei, Y.H., Chu, I.M., Yao, C.L*. “Effect of chondroitin sulphate C on the in vitro and in vivo chondrogenesis of mesenchymal stem cells in crosslinked type II collagen scaffolds, J. Tissue Eng. Regen. Med., 7, 665–672 (2013) 2013 Lai, P.L., Hong, D.W., Liu, T.H., Lai, Z.T., Cheng, M.H., Chen, L.H., Chu, I.M*. “Validity of poly(1, 6-bis-(p-carboxyphenoxy hexane)-co-(sebacic anhydride)) copolymer in biomedical application”, J. Appl. Polym. Sci., 128, 3687-3695 (2013) 2012 Huang, T.Y., Lu, W.C., Chu, I.M.* “A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid”, Bioresource Technol., 123, 8-14 (2012) 2012 Lai, P.L.*, Tai, C.L., Chu, I.M., Fu, T.S., Chen, L.H., Chen, W.J., “Hypothermic manipulation of bone cement can extend the handling time during vertebroplasty” BMC Musculoskelet. Disorder. 13, 198 (2012) 2012 Hong, D.W., Lai, P.L., Chu, I.M.* "Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers" J. React. Func. Polym., 72, 846-855 (2012) 2012 Hus, S.P. Chu, I.M*., “Design of polyanionic nanocarriers based on modified poly (aspartic acid)s for oral administration: synthesis and characterization", J. Polym. Res. 19, 9913-9916 (2012) 2012 Hong, D.W., Lai, P.L., Chu, I.M.* “Effect of mixing ceramics with a thermosensitive biodegradable hydrogel as composite graft”, Composites B, 8, 3088-3095, (2012) 2012 Hus, S.P. Chu, I.M*. “Thermo- and pH-responsive polymersomes of poly (α,β-N-substituted-DL-aspartamide)s", J. Appl. Polym. Sci., 125, 133-144 (2012) 2011 Chen, C.F., Huang, L.Y., Chu, I.M.* “Controlled release of cyclosporine A from biodegradable amphiphilic diblock copolymer sol-gel drug delivery system”, J. Med. Biol. Eng., 31, 177-183 (2011) 2011 Chen, W.C., Wei, Y.H., Huang, J.B., Chu, I.M., Yao, C.L.* “Biological effects of oligo- saccharide chondroitin sulfate C on human articular chondrocytes”, Biomed. Eng.-Appl. Basis Comm. 23, 245-252 (2011) 2011 Hong, D.W., Liu, T.H., Chu, I.M*. “Encapsulation of curcumin by methoxy poly(ethylene glycol-b-aromatic anhydride) micelles", J. Appl. Polym. Sci., 122, 898-907 (2011) 2011 Hong, C.C*., Wang, C.Y., Peng, K.T., Chu, I.M., “A microfluidic chip platform with electrochemical carbon nanotube electrodes for pre-clinical evaluation of antibiotics nanocapsules”, Biosensor. Bioelectronic., 26, 3620-3626 (2011) 2011 Chen, C.F., Shen, H.H., Lin, T.Y., Yu, Y.J., Chen, W.C., Chu, I.M.*, “Studies on the preparation and characterization of mPEG-polyester biodegradable bioglue for bone defect repair”, J. Med. Biol. Eng., 31, 13-17 (2011) 2011 Chen, W. C., Yao, C.L., Chu, I.M., Wei, Y.H*., “Compare the effects of chondrogenesis by culture of human mesenchymal stem cells with various type of the chondroitin sulfate C”, J. Biosci. Bioeng., 111, 226-231 (2011) 2011 Chen, W. C., Yao, C.L., Wei, Y.H., Chu, I.M.*, “Evaluating osteochondral defect repair potential of autologous rabbit bone marrow cells on type II collagen scaffold”, Cytotechnol., 63, 13–23 (2011) 2010 Chen, C.F., Lin, C.T.Y., Chu, I.M.*, “Study of novel biodegradable thermo- sensitive hydrogels of methoxy-poly(ethylene glycol-)block-polyester diblock copolymers”, Polym. Int., 59, 1428-1435 (2010) 2010 Wang, H.M.*, Chen, C.Y., Chen, C.Y., Ho, M. L., Chou, Y.T., Chang, H.C., Wang, C.Z., Chu, I.M., “(-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant”, Bioorg. Med. Chem., 18, 5241-5247 (2010) 2010 徐誠駿, 劉倉豪, 朱一民* “聚乙二醇-聚癸二酸酐與聚乙二醇-聚乳酸共聚物混合微胞於薑黃素之藥物輸送研究”, 化工技術, 207, 102-114 (2010) 2010 Peng, K.T.*, Chen, C.F., Chu, I.M., Li, Y.M., Hsu, W.H., Hsu, R.W.W., Chang, P.J. “Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles”, Biomaterials, 31, 5227-5236 (2010) 2010 Lin, K.L., Yang, D.Y., Chu, I.M., Cheng, F.C., Chen, C,J., Ho, S.P., Pan, H.C.*, "Dura seal as a ligature in the anastomosis of rat sciatic nerve gap injury", J. Surg. Res., 16, 101-110 (2010) 2010 Wu, C.H., Ko, C.S., Huang, J.W., Huang, H.J., Chu, I.M.*, “Effects of exogenous glycosaminoglycans on human chondrocytes cultivated on type II collagen scaffolds”, J. Mater. Sci. Mater. Medicine, 21, 725-729 (2010) 2010 Chang, K.Y., Hung, L.H., Chu, I.M., Huang, L., Ko, C.S., Lee, Y.D.*, “The application of type II collagen and chondroitin sulfate grafted PCL porous scaffold in cartilage tissue engineering”, J. Biomed.Mater. Res. A , 92A, 712-723 (2010) 2009 Chen,T.W., Yao,C.L., Chu,I.M*., Chuang,T.L., Hsieh, T.B., Hwang,S.M., “Large generation of megakaryocytes from serum-free expanded human CD34(+) cells”, Biochem. Biophys. Res. Comm., 378, 112-117 (2009) 2009 Ko, C.S., Huang, J.P., Huang, C.W., Chu, I.M*., “Type II collagen-chondroitin sulfate-hyaluronan scaffold cross-linked by genipin for cartilage tissue engineering”, J. Biosci. Bioeng., 107, 177-182 (2009) 2009 Ko, C.S., Huang, J.P., Huang, C.W., Chu, I.M*., “Type II collagen-chondroitin sulfate-hyaluronan scaffold cross-linked by genipin for cartilage tissue engineering”, J. Biosci. Bioeng., 107, 177-182 (2009) 2009 T.H. Liu and I.M. Chu, "Degradation and localized drug release of polyanhydride microspheres and devices " Journal of Bioscience and Bioengineering, vol. 108, pp. S33-S34 2009. 2009 Lin, Y.J., Yen, C.N., Hu, Y.C., Wu, Y.C. Liao, C.J. Chu, I.M., “Chondrocytes culture in three-dimensional porous alginate scaffolds enhanced cell proliferation, matrix synthesis and gene expression”, J. Biomed. Mater. Res. A, 88A , 23-33 (2009) 2009 Y. J. Lin, C. N. Yen, Y. C. Hu, Y. C. Wu, C. J. Liao, and I. M. Chu, "Chondrocytes culture in three-dimensional porous alginate scaffolds enhanced cell proliferation, matrix synthesis and gene expression," Journal of Biomedical Materials Research Part A, vol. 88A, pp. 23-33, Jan 2009. 2009 C. S. Ko, J. P. Huang, C. W. Huang, and I. M. Chu, "Type II collagen-chondroitin sulfate-hyaluronan scaffold cross-linked by genipin for cartilage tissue engineering," Journal of Bioscience and Bioengineering, vol. 107, pp. 177-182, Feb 2009. 2009 T. W. Chen, C. L. Yao, I. M. Chu, T. L. Chuang, T. B. Hsieh, and S. M. Hwang, "Large generation of megakaryocytes from serum-free expanded human CD34(+) cells," Biochemical and Biophysical Research Communications, vol. 378, pp. 112-117, Jan 2 2009. 2009 T. W. Chen, S. M. Hwang, I. M. Chu, S. C. Hsu, T. B. Hsieh, and C. L. Yao, "Characterization and transplantation of induced megakaryocytes from hematopoietic stem cells for rapid platelet recovery by a two-step serum-free procedure," Experimental Hematology, vol. 37, pp. 1330-1339, Nov 2009. 2009 K. Y. Chang, L. H. Hung, I. M. Chu, C. S. Ko, and Y. D. Lee, "The application of type II collagen and chondroitin sulfate grafted PCL porous scaffold in cartilage tissue engineering," Journal of Biomedical Materials Research Part A, vol. 92A, pp. 712-723, 2009. 2008 Chang Y.C , Chu,I.M , “Methoxy poly(ethylene glycol)-b-poly(valerolactone) diblock polymeric micelles for enhanced encapsulation and protection of camptothecin” , European Polymer Journal44 (2008) 3922–3930 2008 Chen, T.W., Yao, C.L., Chu, I.M., Chuang, T.L., Hsieh, T.B., Hwang, S.M.,”Large generation of megakaryocytes from serum-free expanded human CD34(+) cells”, Biochem Biophys Res Commun. 2008 2008 Liu, S.H., Chu, I.M., Pan, I.H., ”Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes”, J Enzyme Inhib Med Chem. 23(4), 526-534 (2008) 2008 Su, C.H., Fu, C.C., Chang, Y.C., Nair GR, Ye, J.L., Chu I.M., Wu, W.T., “Simultaneous estimation of chlorophyll a and lipid contents in microalgae by three-color analysis”, Biotechnol Bioeng. 99(4), 1034-1039 (2008) 2008 Lee WC, Chu I.M., “Preparation and degradation behavior of polyanhydrides nanoparticles.” J Biomed Mater Res B Appl Biomater. 2008 Jan;84(1):138-46. 2008 Wu, P.H., Nair GR, Chu, I.M., Wu, W.T., “High cell density cultivation of Escherichia coli with surface anchored transglucosidase for use as whole-cell biocatalyst for alpha-arbutin synthesis”, J Ind Microbiol Biotechnol. 35(2), 95-101 (2008) 2007 Liu, S.H., Pan, I.H., Chu, I.M. “Inhibitory effect of p-hydroxybenzyl alcohol on tyrosinase activity and melanogenesis”, Biol. Pharm. Bull., 30, 1135-1139 (2007) 2007 Ko, C.S., Wu, C.H., Huang, H.H., Chu, I.M. “Genipin cross-linking of type II collagen- chondroitin sulfate-hyaluronan scaffold for articular cartilage therapy”, J. Med. Biol. Eng., 27, 7-14 (2007) 2007 Hsieh, H.J., Tung, K.Y., Nair, G.R., Chu, I.M., Wu, W.T., “Production of ascorbic acid glucoside by alginate-entrapped mycelia of Aspergillus niger”, Appl.Microbiol. Biotechnol., 77, 53-60 (2007) 2007 Su, W.T., Liao, Y.F., Chu, I.M., “Observation of fibroblast motility on a micro-grooved hydrophobic elastomer substrate with different geometric characteristics”, Micron, 38, 278–285 (2007) 2007 Zheng, Y., Yeh, C.W., Yang, C.D., Jeng, S.S., Chu, I.M., ”On the local optimal solutions of metabolic regulatory networks using information guided genetic algorithm approach and clustering analysis “, J. Biotechol. 131, 159-167 (2007) 2006 Su, W.T., Chu, I.M., Yang, J.Y., Lin, C.D., “The geometric pattern of a pillared substrate influences the cell-process distribution and shapes of fibroblasts”, Micron, 37, 699-706 (2006) 2006 Lee, W. C., Li, Y. C., Chu, I.M., “Amphiphilic poly(D,L-lactic acid)/poly(ethylene glycol)/ poly(D,L-lactic acid) nanogels for controlled release of hydrophobic drugs”, Macromol. Biosci., 6, 846–854 (2006) 2006 Yao, C.L., Feng, Y.H., Lin, X.Z., Chu, I.M., Hsieh, T.B., Hwang, S.M., “Characterization of serum-free ex vivo-expanded hematopoietic stem cells derived from human umbilical cord blood CD133(+) cells”, Stem Cells Develop., 15, 70-78 (2006) 2005 Chan, C.K., Chu, I.M., “In vitro release of incorporated model compounds in poly(sebacic anhydride-co-ethylene glycol)”, Eur. Polymer J., 41,14031409 (2005) 2004 C.K. Chan, I.M. Chu, C.F Ou and Y.W. Lin, (2004). Interfacial interactions and their influence to phase behavior in poly(vinyl pyrrolidone)/silica hybrid materials prepared by sol-gel process. Material Lett. 58:2243-2247 2004 Ko, C.S., Chu, I.M., “Immobilized cells biocatalyst for the production of S-acetylthio-2-methylpropanic acid”, Enzyme Microb. Technol. 35, 619-623 (2004) 2004 C.L. Yao, C.H. Liu, I.M. Chu, S.M Huang and Z.B. Hsieh, (2004). A systematic strategy to optimize ex vivo expansion medium for human hematopoietic stem cells derived from umbilical cord blood mononuclear cells. Exp. Hematol. 32:720-727 2004 C.K. Chan and I.M. Chu, (2004). In vitro degradation of poly(sebacic anhydride-co- ethylene glycol). Material. Chem. Phys. 88:59-66. 2004 W.T. Su, C.Y. Yang, C.D Lin and I.M. Chu, (2004). Control Cell Behavior on Physical Topographical Surface. Jap. J. Appl. Phys. 43:3906-3809. 2003 Chan, C.K., Chu, I.M., “Crystalline and Dynamic Mechanical Behaviors of Synthesized Poly(Sebacic Anhydride-co-Ethylene Glycol)”, Biomaterials, 24, 47-54 (2003) 2003 Chou, T.H., Chu, I.M., ”Thermodynamic Characteristics of DSPC/DSPE-PEG2000 Mixed Monolayers on the Water Subphase at Different Temperatures”, Colloid.Surf. B 27, 333 – 344 (2003) 2003 T.H Chou, S.C. Chen and I.M. Chu, (2003). Effect of Composition on the Stability of Liposomal Irinotecan Prepared by a pH Gradient Method. J. Biosci. Bioeng. 95:405-408. 2003 S.C. Wu, C.H.Yu, C.W. Lin and I.M. Chu, (2003). The domain III fragment of Japanese encephalitis virus envelope protein: mouse immunogenicity and liposome adjuvanticity. Vaccine 21:2516-2522. 2003 Chan, C.K., Chu, I.M., “Stability and depolymerization of poly(sebacic anhride) under high moisture environment”, J. Appl. Polym. Sci., 89 1423-1429 (2003) 2003 C.L. Yao, C.H. Liu, I.M. Chu, S.M Huang, Z.B.Hsieh, (2003). Factorial deign with steepest ascend path to optimize media for cord blood stem cell cultivation. Enzyme Microb. Technol. 33:343-352. 2003 C.K. Chan and I.M. Chu, (2003). Synthesis and Characterization of Branched Poly (sebacic Acid) using Glycerol. J. Appl. Polym. Sci. 90:886-893. 2003 朱一民, (2003) 生化分離程序. 生化產業技術概論, 吳文騰主編, 清大出版社, 新竹, Chapter 13.

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