个人简介
Education
2001-2005 Ph.D., Bioinformatics, Affiliated with Department of Genetics, North Carolina State University, USA
1996-1998 M.S., Statistics, National Tsing Hua University, Taiwan
1991-1995 B.S., Mathematics, National Taiwan University, Taiwan
近期论文
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Ki-Hok Liao, Wing-Kai Hon, Chuan-Yi Tang, Wen-Ping Hsieh* (2018). MetaSMC: A Coalescent-based ShotgunSequence Simulator for Evolving Microbial Populations . Bioinformatics.(Accepted)
An-Shun Tai, Chien-Hua Peng*, Shih-Chi Peng, Wen-Ping Hsieh* (2018). Decomposing the subclonal structure oftumors with two-way mixture models on copy number aberrations. PLoS ONE13(12): e0206579.
Chien-Hua Peng, Chun-Ta Liao, Ka-Pou Ng, An-Shun Tai, Shih-Chi Peng, Jen-Pao Yeh, Shu-Jen Chen, Kuo-Chien Tsao, Tzu-Chen Yen *, and Wen-Ping Hsieh*. (2015) Somaticcopy number alterations detected by ultra-deep targeted sequencing predictprognosis in oral cavity squamous cell carcinoma. Oncotarget 2015 Aug 14;6(23):19891-906.
Shih-Chi Peng, Chun-Ta Liao,Chien-Hua Peng, Ann-Joy Cheng, Shu-Jen Chen, Chung-Guei Huang, Wen-Ping Hsieh*, Tzu-Chen Yen*. (2014) MicroRNAs miR-218, miR-125b,and let-7g Predict Prognosis in Patients with Oral Cavity Squamous CellCarcinoma. PLoS ONE, 9(7):e102403. doi: 10.1371/journal.pone.0102403
Yen-Jen Lin, Yu-Tin Chen, Shu-NiHsu, Chien-Hua Peng, Chuan-Yi Tang, Tzu-Chen Yen, Wen-Ping Hsieh* (2014) HaplotypeCN: Copy number haplotype inferencewith Hidden Markov Model and localized haplotype cluster. PLoS ONE 9(5): e96841. doi:10.1371/journal.pone.0096841
Pei-Wen Tsai, Yu-Ting Chen,Cheng-Yao Yang, Hsueh-Fen Chen, Te-Sheng Tan, Tzung-Wei Lin, Wen-Ping Hsieh*, Chung-Yu Lan* (2014) The role of Mss11 in Candidaalbicans biofilm formation. Molecular Genetics and Genomics 289(5):807-19.
Yu-Chao Wang, I-Chun Tsai, CheLin, Wen-Ping Hsieh, Chung-YuLan, Yung-Jen Chuang and Bor-Sen Chen. (2014) "Essential FunctionalModules for Pathogenic and Defensive Mechanisms in Candida albicansInfections," BioMed ResearchInternational, vol. 2014, Article ID 136130, 15 pages, 2014.doi:10.1155/2014/136130.
Lai CC, Yeh YH, Hsieh WP, Kuo CT, Wang WC, etal. (2013) Whole-Exome Sequencing to Identify a Novel LMNA Gene MutationAssociated with Inherited Cardiac Conduction Disease. PLoS ONE 8(12): e83322.doi:10.1371/journal.pone.0083322
Peng CH; Jiang YZ; Tai AS; Liu CB;Peng SC; Liao CT; Yen TC; Hsieh WP*. (2013) Causal inference of gene regulation with subnetwork assembly fromgenetical genomics data. NucleicAcids Research; doi: 10.1093/nar/gkt1277.
Wang YC, Lin C, Chuang MT, Hsieh WP, Lan CY, Chuang YJ,Chen BS. (2013) Interspecies protein-protein interaction network construction forcharacterization of host-pathogen interactions: a Candidaalbicans-zebrafish interaction study. BMC Syst Biol. 2013 Aug 16;7:79.doi: 10.1186/1752-0509-7-79.
Chen YY, Chao CC, Liu FC, Hsu PC,Chen HF, Peng SC, Chuang YJ, Lan CY, Hsieh WP, Wong DS. (2013) Dynamictranscript profiling of Candida albicans infection in zebrafish: apathogen-host interaction study. PLoS One. 2013 Sep 03; 10.1371/ journal.pone.0072483
Lin YJ, Chang CT, Tang CY, and Hsieh WP*. (2013)Simpute: An Efficient Solution for Dense Genotypic Data. BioMedResearch International, Volume 2013, Article ID 813912
Chen YT, Lin CY,Tsai PW, Yang CY, Hsieh WP, LanCY. (2011) Rhb1 regulates the expression of secreted aspartic protease 2through the TOR signaling pathway in Candida albicans. Eukaryotic Cell, doi: 10.1128/EC.05200-11
Peng CH, LiaoCT, Peng SC, Chen YJ, Cheng AJ, Juang JL, Tsai CY, Chen TC, Chuang YJ,Tang CY, Hsieh WP*, Yen TC*(2011) A Novel Molecular Signature Identified by Systems Genetics ApproachPredicts Prognosis in Oral Squamous Cell Carcinoma. PLoS One, 6(8): e23452.doi:10.1371/journal.pone.0023452
Hsieh WP*,Chu TM, Lin YM, Wolfinger RD. (2011) Kernel density weighted loessnormalization improves the performance of detection within asymmetricaldata. BMC Bioinformatics, 12:222
Hsu JT, Peng CH, Hsieh WP, Lan CY, Tang CY.(2011) A novel method to identify cooperative functional modules: studyof module coordination in the Saccharomyces cerevisiae cell cycle. BMC Bioinformatics, 12:281.
Chang PC, Fitzgerald LD, Hsia DA,Izumiya Y, Wu CY, Hsieh WP, LinSF, Campbell M, Lam KS, Luciw PA, Tepper CG, Kung HJ. (2011) Histonedemethylase JMJD2A regulates KSHV replication and is targeted by a viraltranscriptional factor. Journal ofVirology, doi:10.1128/JVI.02485-10
Wang YC, Lan CY, Hsieh WP, Murillo LA, AgabianN, Chen BS. (2010) Global screening of potential Candida albicans biofilm-relatedtranscription factors via network comparison. BMC Bioinformatics, 11:53
Hsieh WP*,Chu TM, and Wolfinger RD. (2007) Comparison of statistical performance ofunivariate and bivariate mixed models for Affymetrix probe level data. Journal of Statistical Computationand Simulation. 77(3) 251-264.
Passador-Gurgel G, Hsieh WP, Hunt P, Deighton N,Gibson G. (2007) Quantitative Trait Transcripts for Nicotine Resistance inDrosophila melanogaster. Naturegenetics, 39(2):264-8.
Hsieh WP,Passador-Gurgel G, Stone EA, Gibson G. (2007) Mixture modeling of transcript abundance classes in naturalpopulations. Genome Biology,8(6):R98
Tsai S, Mir B, Martin AC, EstradaJL, Bischoff SR, Hsieh WP,Cassady JP, Freking BA, Nonneman DJ, Rohrer GA, Piedrahita JA. (2006)Detection of transcriptional difference of porcine imprinted genes usingdifferent microarray platforms. BMCGenomics, 7:328.
Hsieh WP, Chu TM, Wolfinger RD, and Gibson G. (2003)Mixed model reanalysis of primate data suggests tissue and species biasesin oligonucleotide-based gene expression profiles. Genetics, 165: 747-757.
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