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Representative Publications
Kai, M., Lei, J. H., Valecha, M. V., Zhang, A., Xu, J., Wang, L., Lyu, X., Chen, S., Miao, Z., Zhang, X., Su, S., Shao, F., Rajendran, B. K., Bao, J., Zeng, J., Sun, H., Chen, P., Tan, K., Chen, Q., Wong, K. H., Xu, X., and Deng, C. (2020) NOTCH1 Activation Compensates BRCA1 Deficiency and Promotes Triple-Negative Breast Cancer Formation. Nat Commun (Accepted)
Tan, K., and Wong, K. H. (2019) RNA Polymerase II ChIP-Seq-a Powerful and Highly Affordable Method for Studying Fungal Genomics and Physiology. Biophysical Reviews 11, 79-82
Qin, L. G., Li, A., Tan, K., Guo, S. h., Chen, Y. Y., Wang, F., and Wong, K. H. (2019) Universal Plasmids to Facilitate Gene Deletion and Gene Tagging in Filamentous Fungi. Fungal Genet Biol 125, 28-35
Choi, G. C. G., Zhou, P., Yuen, C. T. L., Chan, B. K. C., Xu, F., Bao, S., Chu, H. Y., Thean, D., Tan, K., Wong, K. H., Zheng, Z. L., and Wong, A. S. L. (2019) Combinatorial Mutagenesis En Masse Optimizes the Genome Editing Activities of SpCas9. Nat Methods 16, 722-730
Zhang, B. Y., Lyu, J. F., Liu, Y. F., Wu, C. J., Yang, E. J., Pardeshi, L., Tan, K., Wong, K. H., Chen, Q., Xu, X. l., Deng, C. X., and Shim, J. S. (2018) BRCA1 Deficiency Sensitizes Breast Cancer Cells to Bromodomain and Extra-Terminal Domain (BET) Inhibition. Oncogene 37, 6341-6356
Veri, A., Miao, Z. Q., Shapiro, R., Tebbji, F., O’Meara, T., Kim, S. H., Colazo, J., Tan, K., Vyas, V., Whiteway, M., Robbins, N., Wong, K. H., and Cowen, L. (2018) Tuning Hsf1 Levels Drives Distinct Fungal Morphogenetic Programs with Depletion Impairing Hsp90 Function and Overexpression Expanding the Target Space. Plos Genet 14, e1007270
Liu, Y., Yang, E. J., Zhang, B. Y., Miao, Z. Q., Wu, C. J., Lyu, J. F., Tan, K., Poon, T. C. W., and Shim, J. S. (2018) PTEN Deficiency Confers Colorectal Cancer Cell Resistance to Dual Inhibitors of FLT3 and Aurora kinase A. Cancer Lett 436, 28-37
Xie, J. L., Qin, L. G., Miao, Z. Q., Grys, B., Diaz, J. D. L. C., Ting, K., Krieger, J., Tong, J. F., Tan, K., Leach, M., Ketela, T., Moran, M., Krysan, D., Boone, C., Andrews, B., Selmecki, A., Wong, K. H., Robbins, N., and Cowen, L. (2017) The Candida Albicans Transcription Factor Cas5 Couples Stress Responses, Drug Resistance and Cell Cycle Regulation. Nat Commun 8, 499
Leach, M. D., Farrer, R. A., Tan, K., Miao, Z., Walker, L. A., Cuomo, C. A., Wheeler, R. T., Brown, A. J., Wong, K. H., and Cowen, L. E. (2016) Hsf1 and Hsp90 Orchestrate Temperature-Dependent Global Transcriptional Remodelling and Chromatin Architecture in Candida Albicans. Nat Commun 7, 11704
Tan, K., Roberts, A. J., Chonofsky, M., Egan, M. J., and Reck-Peterson, S. L. (2014) A Microscopy-Based Screen Employing Multiplex Genome Sequencing Identifies Cargo-Specific Requirements for Dynein Velocity. Mol Biol Cell 25, 669-678
Downes, D. J., Chonofsky, M., Tan, K., Pfannenstiel, B. T., Reck-Peterson, S. L., and Todd, R. B. (2014) Characterization of the Mutagenic Spectrum of 4-Nitroquinoline 1-Oxide (4-NQO) in Aspergillus Nidulans by Whole Genome Sequencing. G3 (Bethesda) 4, 2483-2492
Egan, M. J., Tan, K., and Reck-Peterson, S. L. (2012) Lis1 Is an Initiation Factor for Dynein-Driven Organelle Transport. J Cell Biol 197, 971-982
Zhang, J., Tan, K., Wu, X., Chen, G., Sun, J., Reck-Peterson, S. L., Hammer, J. A., 3rd, and Xiang, X. (2011) Aspergillus myosin-V Supports Polarized Growth in the Absence of Microtubule-Based Transport. PLoS One 6, e28575
Pal, B., Chan, N. C., Helfenbaum, L., Tan, K., Tansey, W. P., and Gething, M. J. (2007) SCFCdc4-Mediated Degradation of the Hac1p Transcription Factor Regulates the Unfolded Protein Response in Saccharomyces Cerevisiae. Mol Biol Cell 18, 426-440
Oon, C. J., Chen, W. N., Goh, K. T., Mesenas, S., Ng, H. S., Chiang, G., Tan, C., Koh, S., Teng, S. W., Toh, I., Moh, M. C., Goo, K. S., Tan, K., Leong, A. L., and Tan, G. S. (2002) Molecular Characterization of Hepatitis B Virus Surface Antigen Mutants in Singapore Patients with Hepatocellular Carcinoma and Hepatitis B Virus Carriers Negative for HBsAg but Positive for anti-HBs and anti-HBc. J Gastroenterol Hepatol 17 Suppl, S491-496