个人简介

Education PhD Mechanical Engineering (Biomedical Direction), University of Sciences and Technology of China, Hefei, China (2002) Academic and Professional Experience 08/2017-present Associate Professor, Faculty of Health Sciences, University of Macau 08/2013-08/2017 Assistant Professor, Faculty of Health Sciences, University of Macau Research Field: Molecular Imaging and Neuroimaging. 10/2012-06/2013 Clinical Assistant Professor, Department of Psychology/School of Communication, Arizona State University Research Field: EEG-fMRI fusion 09/2007-10/2012 Research Assistant Professor, Biomedical Engineering Department, University of Florida. Research Field: Biomedical Imaging and Biomedical Optics 01/2005-09/2007 Postdoctoral Research Associate, Biomedical Engineering Department, University of Florida, Gainesville, FL32611. Research Field: Biomedical Imaging and Signal Processing 03/2004-01/2005 Postdoctoral Research Fellow, Department of Physics, Clemson University, SC29634 Research Field: Biomedical Optical Imaging 03/2002-03/2004 Postdoctoral Research Scientist, Institute of High performance Computing, National University of Singapore, Singapore 117523. Research Field: BioMEMS and Biomaterials Course Outlines HSCI3000 Neuroscience and Neurodegenerative Diseases Advanced Biomedical and Chemical Engineering

研究领域

Neurosciences and Neuroimaging Neuroimaging Brain Disorders and Brain Cognition Hyperscanning Optogenetics, Brain Intervention and Brain Modulation Biomedical Optics and Optical Molecular Imaging Diffuse Optical Tomography(DOT); Functional Near Infrared Spectroscopy (fNIRS); Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM); Optical Coherence Tomography(OCT); Photothermal and Photodynamic Therapy; Molecular Imaging and Cancer Nanomedicine;

Patents Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, International Application No. PCT/US2008/055894. METHOD AND APPARATUS FOR TOMOGRAPHIC IMAGING OF ABSOLUTE OPTICAL ABSORPTION COEFFICIENT IN TURBID MEDIA USING COMBINED PHOTOACOUSTIC AND DIFFUSING LIGHT MEASUREMENTS (WO/2009/011934) 一种融合光声显微，荧光显微和超声成像于一体的多模态显微成像系统。中国专利号201820951744.5。

近期论文

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Representative Publications Neurophotonics and Neuroscience Xu, S. Y., Lu, F. M., Wang, M. Y., Hu, Z. S., Zhang, J., Chen, Z. Y., Armada-da-Silva, P. A. S., and Yuan, Z. (2020) Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children with Down’s Syndrome: An fNIRS Study. Front Hum Neurosci 14, 6 Wang, M. Y., Zhang, Z. M., Miao, X. C., Lin, X. H., and Yuan, Z. (2020) Electrophysiological Evidence of Attentional Avoidance in Sub-Clinical Individuals with Obsessive-Compulsive Symptoms. IEEE Access 8, 91020-91027 Ieong, H. F.-h., and Yuan, Z. (2019) Desynchronized Lower Alpha Rhythms Were Associated with Functional Ischemia in the Prefrontal Cortex in Heroin Patients after Protracted Abstinence: A Concurrent EEG-fNIRS Study. Biol Psychiat 85, S295-S296 Ieong, H. F. H., Gao, F., and Yuan, Z. (2019) Machine Learning: Assessing Neurovascular Signals in the Prefrontal Cortex with Non-Invasive Bimodal Electro-Optical Neuroimaging in Opiate Addiction. Sci Rep 9, 18262 Hu, Z. S., Zhang, J., Zhang, L. Y., Xiang, Y. T., and Yuan, Z. (2019) Linking Brain Activation to Topological Organization in the Frontal Lobe as a Synergistic Indicator to Characterize the Difference between Various Cognitive Processes of Executive Functions. Neurophotonics 6, 025008 Hu, Z. S., Lam, K. F., and Yuan, Z. (2019) Effective Connectivity of the Fronto-Parietal Network During the Tangram Task in a Natural Environment. Neuroscience 422, 202-211 Hu, Z. S., Lam, K. F., Xiang, Y. T., and Yuan, Z. (2019) Causal Cortical Network for Arithmetic Problem-Solving Represents Brain’s Planning Rather Than Reasoning. Int J Biol Sci 15, 1148-1160 Wang, M. Y., Zhang, J., Lu, F. M., Xiang, Y. T., and Yuan, Z. (2018) Neuroticism and Conscientiousness Respectively Positively and Negatively Correlated with the Network Characteristic Path Length in Dorsal Lateral Prefrontal Cortex: A Resting-State fNIRS Study. Brain Behav, e01074 Wang, M. Y., Lu, F. M., Hu, Z. S., Zhang, J., and Yuan, Z. (2018) Optical Mapping of Prefrontal Brain Connectivity and Activation During Emotion Anticipation. Behav Brain Res 350, 122-128 Ren, H. H., Wang, M. Y., He, Y., Du, Z. C., Zhang, J., and Yuan, Z. (2018) A Novel Phase Analysis Method for Examining fNIRS Neuroimaging Data Associated with Chinese/English Sight Translation. Behav Brain Res 361, 151-158 Lin, X. H., Sai, L. Y., and Yuan, Z. (2018) Detecting Concealed Information with Fused Electroencephalography and Functional near-Infrared Spectroscopy. Neuroscience 386, 284-294 Lin, X. H., Lei, V. L. C., Li, D. F., and Yuan, Z. (2018) Which Is More Costly in Chinese to English Simultaneous Interpreting, “Pairing” or “Transphrasing”? Evidence from an fNIRS Neuroimaging Study. Neurophotonics 5, 025010 Ieong, H. F. H., and Yuan, Z. (2018) Emotion Recognition and Its Relation to Prefrontal Function and Network in Heroin Plus Nicotine Dependence: A Pilot Study. Neurophotonics 5, 025011 Hu, Z. S., Zhang, J., Couto, T. A., Xu, S. Y., Luan, P., and Yuan, Z. (2018) Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex During Chinese Character Recognition. Brain Topogr 31, 1014-1028 Zhang, Z. M., Wang, M. Y., Guo, X. W., Miao, X. C., Zhang, T., Gao, D., and Yuan, Z. (2017) Attentional Avoidance of Threats in Obsessive Compulsive Disorder: An Event Related Potential Study. Behaviour Research and Therapy 97, 96-104 Zhang, Z. M., Wang, M., Miao, X. C., Li, Y. J., Hitchman, G., and Yuan, Z. (2017) Individuals with High Obsessive-Compulsive Tendencies or Undermined Confidence Rely More on External Proxies to Access Their Internal States. Journal of Behavior Therapy and Experimental Psychiatry 54, 263-269 Lu, F. M., Zhou, J. S., Wang, X. P., Xiang, Y. T., and Yuan, Z. (2017) Short-and Long-Range Functional Connectivity Density Alterations in Adolescents with Pure Conduct Disorder at Resting-State. Neuroscience 351, 96-107 Liu, C. H. M., Xin, Yuan, Z., Song, L. P., Jing, B., Lu, H. Y., Tang, L. R., Fan, J. F., Walter, M., Liu, C. Z., Wang, L. H., and Wang, C. Y. (2017) Decreased Resting-State Activity in the Precuneus Is Associated with Depressive Episodes in Recurrent Depression. The Journal of clinical psychiatry 78, E372-+ He, Y., Wang, M. Y., Li, D. F., and Yuan, Z. (2017) Optical Mapping of Brain Activation During the English to Chinese and Chinese to English Sight Translation. Biomed Opt Express 8, 5399-5411 Zhang, J., Li, Y. Y., Chen, H. F., Ding, J. R., and Yuan, Z. (2016) An Investigation of the Differences and Similarities between Generated Small-World Networks for Right-and Left-Hand Motor Imageries. Sci Rep-Uk 6, 36562 Liu, C. H., Liu, C. Z., Zhang, J. H., Yuan, Z., Tang, L. R., Tie, C. L., Fan, J., and Liu, Q. Q. (2016) Reduced Spontaneous Neuronal Activity in the Insular Cortex and Thalamus in Healthy Adults with Insomnia Symptoms. Brain Res 1648, 317-324 Yuan, Z. (2013) Combining Independent Component Analysis and Granger Causality to Investigate Brain Network Dynamics with fNIRS Measurements. Biomed Opt Express 4, 2629-2643 Yuan, Z. (2013) Fusion of fNIRS and fMRI Data: Identifying When and Where Hemodynamic Signals Are Changing in Human Brains. Front Hum Neurosci 7, 676 Optical Molecular Imaging Wang, D., Xue, B., Ohulchanskyy, T. Y., Liu, Y., Yakovliev, A., Ziniuk, R., Xu, M. Z., Song, J., Qu, J. L., and Yuan, Z. (2020) Inhibiting Tumor Oxygen Metabolism and Simultaneously Generating Oxygen by Intelligent Upconversion Nanotherapeutics for Enhanced Photodynamic Therapy. Biomaterials 251, 120088 Men, X. J., Wang, F., Chen, H. B., Liu, Y. B., Men, X. X., Yuan, Y., Zhang, Z., Gao, D. Y., Wu, C. F., and Yuan, Z. (2020) Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy. Adv Funct Mater, 1909673 Fan, X. x., Xu, M. z., Leung, E. L. H., Jun, C., Yuan, Z., and Liu, L. (2020) ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria. Nano-Micro Lett 12, 76 Zhang, B. Y., Wang, F., Zhou, H., Gao, D. Y., Yuan, Z., Wu, C. F., and Zhang, X. J. (2019) Polymer Dots Compartmentalized in Liposomes as Photocatalyst for in Situ Hydrogen Therapy. Angew Chem Int Edit 58, 2744-2748 Xu, H., Ohulchanskyy, T. Y., Yakovliev, A., Zinyuk, R., Song, J., Liu, L. W., Qu, J. L., and Yuan, Z. (2019) Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. Theranostics 9, 1323-1335 Wang, S. C., Sheng, Z. H., Yang, Z. G., Hu, D. H., Long, X. J., Feng, G., Liu, Y. B., Yuan, Z., Zhang, J. J., Zheng, H. R., and Zhang, X. J. (2019) Activatable Small-Molecule Photoacoustic Probes That Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease. Angew Chem Int Ed Engl 58, 12415-12419 Gao, D. Y., Zhang, B. Y., Liu, Y. B., Hu, D. H., Sheng, Z. H., Zhang, X. J., and Yuan, Z. (2019) Molecular Engineering of near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics. Theranostics 9, 5315-5331 Chang, K. W., Gao, D. Y., Qi, Q. F., Liu, Y. B., and Yuan, Z. (2019) Engineering Biocompatible Benzodithiophene-Based Polymer Dots with Tunable Absorptions as High-Efficiency Theranostic Agents for Multiscale Photoacoustic Imaging-Guided Photothermal Therapy. Biomater Sci-Uk 7, 1486-1492 Zhang, D., Xu, H., Zhang, X. L., Liu, Y. B., Wu, M., Li, J., Yang, H. H., Liu, G., Liu, X. L., Liu, J. F., and Yuan, Z. (2018) Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second near-Infrared Window Photochemotherapy. Acs Appl Mater Inter 10, 25203-25212 Sun, K., Yang, Y. K., Zhou, H., Yin, S. Y., Qin, W. P., Yu, J. B., Chiu, D., Yuan, Z., Zhang, X. J., and Wu, C. F. (2018) Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring Via a Smartphone. Acs Nano 12, 5176-5184 Gao, D. Y., Zhang, P. F., Liu, Y. B., Sheng, Z. H., Chen, H. J., and Yuan, Z. (2018) Protein-Modified Conjugated Polymer Nanoparticles with Strong near-Infrared Absorption: A Novel Nanoplatform to Design Multifunctional Nanoprobes for Dual-Modal Photoacoustic and Fluorescence Imaging. Nanoscale 10, 19742-19748 Gao, D. Y., Ji, X., Wang, J. L., Wang, Y. T., Li, D. L., Liu, Y. B., Chang, K. W., Qu, J. L., Zheng, J., and Yuan, Z. (2018) Engineering a Protein-Based Nanoplatform as an Antibacterial Agent for Light Activated Dual-Modal Photothermal and Photodynamic Therapy of Infection in Both the NIR I and II Windows. J Mater Chem B 6, 732-739 Chang, K. W., Liu, Y. B., Hu, D. H., Qi, Q. F., Gao, D. Y., Wang, Y. T., Li, D. L., Zhang, X. J., Zheng, H. R., Sheng, Z. H., and Yuan, Z. (2018) Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy. Acs Appl Mater Inter 10, 7012-7021 Zhang, J., Chen, H. B., Zhou, T., Wang, L. M., Gao, D. Y., Zhang, X. J., Liu, Y. B., Wu, C. F., and Yuan, Z. (2017) A PIID-DTBT Based Semi-Conducting Polymer Dots with Broad and Strong Optical Absorption in the Visible-Light Region: Highly Effective Contrast Agents for Multiscale and Multi-Spectral Photoacoustic Imaging. Nano Res 10, 64-76 Gao, D. Y., Sheng, Z. H., Liu, Y. B., Hu, D. H., Zhang, J., Zhang, X. J., Zheng, H. R., and Yuan, Z. (2017) Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for in Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging. Adv Healthc Mater 6 Chen, H. B., Zhang, J., Chang, K. W., Men, X. J., Fang, X. F., Zhou, L. B., Li, D. L., Gao, D. Y., Yin, S. Y., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Highly Absorbing Multispectral near-Infrared Polymer Nanoparticles from One Conjugated Backbone for Photoacoustic Imaging and Photothermal Therapy. Biomaterials 144, 42-52 Chang, K. W., Liu, Z. H., Fang, X. F., Chen, H. B., Men, X. J., Yuan, Y., Sun, K., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Enhanced Phototherapy by Nanoparticle-Enzyme Via Generation and Photolysis of Hydrogen Peroxide. Nano Lett 17, 4323-4329 Biomedical Optics and Optical Imaging Liu, Y. B., Zhang, L. Y., Li, S. S., Han, X. N., and Yuan, Z. (2018) Imaging Molecular Signatures for Clinical Detection of Scleroderma in the Hand by Multispectral Photoacoustic Elastic Tomography. J Biophotonics 11, e201700267 Liu, Y. B., Gao, D. Y., Xu, M. Z., and Yuan, Z. (2018) Multispectral Photoacoustic Imaging of Cancer with Broadband CuS Nanoparticles Covering Both NIR-I and NIR-II Biological Windows. J Biophotonics, e201800237 Zhang, J., Liu, J., Wang, L. M., Li, Z. Y., and Yuan, Z. (2017) Retroreflective-Type Janus Microspheres as a Novel Contrast Agent for Enhanced Optical Coherence Tomography. J Biophotonics 10, 878-886 Liu, Y. B., and Yuan, Z. (2016) Multi-Spectral Photoacoustic Elasticity Tomography. Biomed Opt Express 7, 3323-3334 Liu, Y. B., Jiang, H. B., and Yuan, Z. (2016) Two Schemes for Quantitative Photoacoustic Tomography Based on Monte Carlo Simulation. Med Phys 43, 3987-3997 Zhang, J., Ge, W., and Yuan, Z. (2015) In Vivo Three-Dimensional Characterization of the Adult Zebrafish Brain Using a 1325 Nm Spectral-Domain Optical Coherence Tomography System with the 27 Frame/S Video Rate. Biomed Opt Express 6, 3932-3940 Yuan, Z., Zhang, J., Wang, X. D., and Li, C. Q. (2014) A Systematic Investigation of Reflectance Diffuse Optical Tomography Using Nonlinear Reconstruction Methods and Continuous Wave Measurements. Biomed Opt Express 5, 3011-3022 Yuan, Z., and Jiang, H. (2012) A Calibration-Free, One-Step Method for Quantitative Photoacoustic Tomography. Med Phys 39, 6895-6899 Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) High-Resolution X-Ray Guided Three-Dimensional Diffuse Optical Tomography of Joint Tissues in Hand Osteoarthritis: Morphological and Functional Assessments. Med Phys 37, 4343-4354 Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) Image-Guided Optical Spectroscopy in Diagnosis of Osteoarthritis: A Clinical Study. Biomed Opt Express 1, 74-86 Yuan, Z., and Jiang, H. (2009) Quantitative Photoacoustic Tomography. Philos Trans A Math Phys Eng Sci 367, 3043-3054 Yuan, Z., and Jiang, H. (2009) Simultaneous Recovery of Tissue Physiological and Acoustic Properties and the Criteria for Wavelength Selection in Multispectral Photoacoustic Tomography. Opt Lett 34, 1714-1716 Yuan, Z., Hu, X. H., and Jiang, H. (2009) A Higher Order Diffusion Model for Three-Dimensional Photon Migration and Image Reconstruction in Optical Tomography. Phys Med Biol 54, 65-88 Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2008) Tomographic X-Ray-Guided Three-Dimensional Diffuse Optical Tomography of Osteoarthritis in the Finger Joints. J Biomed Opt 13, 044006 Yuan, Z., Zhang, Q., Sobel, E., and Jiang, H. (2007) Three-Dimensional Diffuse Optical Tomography of Osteoarthritis: Initial Results in the Finger Joints. J Biomed Opt 12, 034001 Yuan, Z., Wang, Q., and Jiang, H. (2007) Reconstruction of Optical Absorption Coefficient Maps of Heterogeneous Media by Photoacoustic Tomography Coupled with Diffusion Equation Based Regularized Newton Method. Opt Express 15, 18076-18081 Yuan, Z., and Jiang, H. (2007) Three-Dimensional Finite-Element-Based Photoacoustic Tomography: Reconstruction Algorithm and Simulations. Med Phys 34, 538-546 Yuan, Z., Zhang, Q., and Jiang, H. (2006) Simultaneous Reconstruction of Acoustic and Optical Properties of Heterogeneous Media by Quantitative Photoacoustic Tomography. Opt Express 14, 6749-6754 Yuan, Z., and Jiang, H. (2006) Quantitative Photoacoustic Tomography: Recovery of Optical Absorption Coefficient Maps of Heterogeneous Media. Appl Phys Lett 88 Yuan, Z., Wu, C., Zhao, H., and Jiang, H. (2005) Imaging of Small Nanoparticle-Containing Objects by Finite-Element-Based Photoacoustic Tomography. Opt Lett 30, 3054-3056

学术兼职

Senior Member of SPIE Senior Member of OSA Senior Member of China Biomedical Engineering Society Senior Member of China Biomedical Optics Society Committee Members of China Biomedical Engineering Society Associate Editor of BMC Medical Imaging Associate Editor of Frontiers in Human Neuroscience Editorial Member of Quantitative Imaging in Medicine and Surgery Special issue Editor for Biomedical Research International Special issue Editor for Journal of Innovative Optical Health Sciences Special issue Editor for Frontiers in Human Neuroscience Special issue Editor for Biomed Research International Guess Associate Editor of Medical Physics