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Representative Publications
Zhang, B. Y., Lyu, J. F., Yang, E. J., Liu, Y. F., Wu, C. J., Pardeshi, L., Tan, K. L., Chen, Q., Xu, X. L., Deng, C. X., and Shim, J. S. (2020) Class I Histone Deacetylase Inhibition Is Synthetic Lethal with BRCA1 Deficiency in Breast Cancer Cells. Acta Pharm Sin B 10, 615-627
Liu, Y. F., Yang, E. J., Shi, C. X., Mou, P. K., Zhang, B. Y., Wu, C. J., Lyu, J. F., and Shim, J. S. (2020) Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT. Int J Biol Sci 16, 1774-1784
Lyu, J. F., Yang, E. J., and Shim, J. S. (2019) Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer. Cells 8, E389
Zhang, B. Y., Lyu, J. F., Liu, Y. F., Wu, C. J., Yang, E. J., Pardeshi, L., Tan, K., Wong, K. H., Chen, Q., Xu, X. l., Deng, C. X., and Shim, J. S. (2018) BRCA1 Deficiency Sensitizes Breast Cancer Cells to Bromodomain and Extra-Terminal Domain (BET) Inhibition. Oncogene 37, 6341-6356
Wu, C. J., Lyu, J. F., Yang, E. J., Liu, Y. F., Zhang, B. Y., and Shim, J. S. (2018) Targeting AURKA-CDC25C Axis to Induce Synthetic Lethality in ARID1A-Deficient Colorectal Cancer Cells. Nat Commun 9, 3212
Lyu, J. F., Yang, E. J., Head, S., Ai, N., Zhang, B. Y., Wu, C. J., Li, R. J., Liu, Y. F., Chakravarty, H., Zhang, S. L., Tam, K. Y., Dang, Y. J., Kwon, H. J., Ge, W., Liu, J. O., and Shim, J. S. (2018) Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking. Int J Biol Sci 14, 1175-1185
Liu, Y., Yang, E. J., Zhang, B. Y., Miao, Z. Q., Wu, C. J., Lyu, J. F., Tan, K., Poon, T. C. W., and Shim, J. S. (2018) PTEN Deficiency Confers Colorectal Cancer Cell Resistance to Dual Inhibitors of FLT3 and Aurora kinase A. Cancer Lett 436, 28-37
Lyu, J. F., Yang, E. J., Head, S., Ai, N., Zhang, B. Y., Wu, C. J., Li, R. J., Liu, Y. F., Yang, C., Dang, Y. J., Kwon, H. J., Ge, W., Liu, J. O., and Shim, J. S. (2017) Pharmacological Blockade of Cholesterol Trafficking by Cepharanthine in Endothelial Cells Suppresses Angiogenesis and Tumor Growth. Cancer Lett 409, 91-103
Head, S., Shi, W., Yang, E. J., Nacev, B., Hong, S., Pasunooti, K., Li, R. J., Shim, J. S., and Liu, J. O. (2017) Simultaneous Targeting of Npc1 and Vdac1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis. Acs Chem Biol 12, 174-182
Shim, J. S., Li, R. J., Bumpus, N., Head, S., Pasunooti, K. K., Yang, E. J., Lv, J. f., Shi, W., and Liu, J. O. (2016) Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole. Clin Cancer Res 22, 2709-2720
Du, B. W., and Shim, J. S. (2016) Targeting Epithelial–Mesenchymal Transition (Emt) to Overcome Drug Resistance in Cancer. Molecules 21, 965
Cho, Y. S., Yen, C. n., Shim, J. S., Kang, D. H., Kang, S. W., Liu, J. O., and Kwon, H. J. (2016) Antidepressant Indatraline Induces Autophagy and Inhibits Restenosis Via Suppression of mTOR/S6 Kinase Signaling Pathway. Sci Rep-Uk 6, 34655
Wang, G. L., Rajpurohit, S., Delaspre, F., Walker, S., White, D., Ceasrine, A., Kuruvilla, R., Li, R. j., Shim, J. S., Liu, J. O., Parsons, M., and Mumm, J. (2015) First Quantitative High-Throughput Screen in Zebrafish Identifies Novel Pathways for Increasing Pancreatic Β-Cell Mass. Elife 4, e08261
Shim, J. S., Li, R. J., Lv, J. F., Head, S., Yang, E. J., and Liu, J. O. (2015) Inhibition of Angiogenesis by Selective Estrogen Receptor Modulators through Blockade of Cholesterol Trafficking Rather Than Estrogen Receptor Antagonism. Cancer Lett 362, 106-115
Head, S. A., Shi, W., Zhao, L., Gorshkov, K., Pasunooti, K., Chen, Y., Deng, Z., Li, R. j., Shim, J. S., Tan, W., Hartung, T., Zhang, J., Zhao, Y., Colombini, M., and Liu, J. O. (2015) Antifungal Drug Itraconazole Targets Vdac1 to Modulate the Ampk/mTOR Signaling Axis in Endothelial Cells. Proceedings of the National Academy of Sciences 112, E7276-E7285
Wang, M. H., Shim, J. S., Li, R. J., Dang, Y. J., He, Q. L., Das, M., and Liu, J. O. (2014) Identification of an Old Antibiotic Clofoctol as a Novel Activator of Unfolded Protein Response Pathways and an Inhibitor of Prostate Cancer. Brit J Pharmacol 171, 4478-4489
Shim, J. S., and Liu, J. O. (2014) Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs. Int J Biol Sci 10, 654-663
Kamiyama, H., Rauenzahn, S., Shim, J. S., Karikari, C. A., Feldmann, G., Hua, L., Kamiyama, M., Schuler, F. W., Lin, M. T., Beaty, R. M., Karanam, B., Liang, H., Mullendore, M. E., Mo, G., Hidalgo, M., Jaffee, E., Hruban, R. H., Jinnah, H. A., Roden, R. B., Jimeno, A., Liu, J. O., Maitra, A., and Eshleman, J. R. (2013) Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice. Clin Cancer Res 19, 1139-1146
Choi, S. M., Kim, Y., Shim, J. S., Park, J. T., Wang, R. H., Leach, S. D., Liu, J. O., Deng, C., Ye, Z., and Jang, Y. Y. (2013) Efficient Drug Screening and Gene Correction for Treating Liver Disease Using Patient-Specific Stem Cells. Hepatology 57, 2458-2468
Shim, J. S., Rao, R., Beebe, K., Neckers, L., Han, I., Nahta, R., and Liu, J. O. (2012) Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir. J Natl Cancer Inst 104, 1576-1590
Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S. J., Anders, R. A., Liu, J. O., and Pan, D. (2012) Genetic and Pharmacological Disruption of the TEAD-YAP Complex Suppresses the Oncogenic Activity of YAP. Genes Dev 26, 1300-1305
Rovira, M., Huang, W., Yusuff, S., Shim, J. S., Ferrante, A. A., Liu, J. O., and Parsons, M. J. (2011) Chemical Screen Identifies FDA-Approved Drugs and Target Pathways That Induce Precocious Pancreatic Endocrine Differentiation. Proc Natl Acad Sci U S A 108, 19264-19269
Platz, E. A., Yegnasubramanian, S., Liu, J. O., Chong, C. R., Shim, J. S., Kenfield, S. A., Stampfer, M. J., Willett, W. C., Giovannucci, E., and Nelson, W. G. (2011) A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment. Cancer Discov 1, 68-77
Shim, J. S., Matsui, Y., Bhat, S., Nacev, B. A., Xu, J., Bhang, H. E., Dhara, S., Han, K. C., Chong, C. R., Pomper, M. G., So, A., and Liu, J. O. (2010) Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer. J Natl Cancer Inst 102, 1855-1873
Shim, J. S., Lee, H. K., Park, H. M., Kim, J. O., Kim, E. K., Hwang, K. H., Kim, K. T., Park, S. W., Lee, J. H., and Kwon, H. J. (2005) Development of Anangiogenesis-Focused cDNA Chip and Validation of Its Functionality. Exp Mol Med 37, 365-370
Shim, J. S., Lee, J., Park, H. J., Park, S. J., and Kwon, H. J. (2004) A New Curcumin Derivative, HBC, Interferes with the Cell Cycle Progression of Colon Cancer Cells Via Antagonization of the Ca2+/Calmodulin Function. Chem Biol 11, 1455-1463
Shim, J. S., Lee, H. S., Shin, J., and Kwon, H. J. (2004) Psammaplin A, a Marine Natural Product, Inhibits Aminopeptidase N and Suppresses Angiogenesis in Vitro. Cancer Lett 203, 163-169
Shim, J. S., and Kwon, H. J. (2004) Chemical Genetics for Therapeutic Target Mining. Expert Opin Ther Targets 8, 653-661
Shim, J. S., Kim, D. H., and Kwon, H. J. (2004) Plakoglobin Is a New Target Gene of Histone Deacetylase in Human Fibrosarcoma HT1080 Cells. Oncogene 23, 1704-1711
Shim, J. S., Kim, J. H., Cho, H. Y., Yum, Y. N., Kim, S. H., Park, H. J., Shim, B. S., Choi, S. H., and Kwon, H. J. (2003) Irreversible Inhibition of CD13/aminopeptidase N by the Antiangiogenic Agent Curcumin. Chem Biol 10, 695-704