近期论文
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Representative Publications
Selected publications (Total >100 papers, cited more than 4000 times. 12 papers cited >100 times, coresspoding author*)
Zeng, Z.; Xu, J.; Zheng, W*., Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox biology 2017, 12, 625-633. IF 9.04.
Chong, C.-M.; Zheng, W*., Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling. Redox biology 2016, 9, 50-56. IF 9.04.
Zheng, W*.; Meng, Q.; Wang, H.; Yan, F.; Little, P. J.; Deng, X.; Lin, S., IGF-1-mediated survival from induced death of human primary cultured retinal pigment epithelial cells is mediated by an Akt-dependent signaling pathway. Molecular neurobiology 2018, 55 (3), 1915-1927. IF 6.17
Liao, R.; Yan, F.; Zeng, Z.; Wang, H.; Qiu, K.; Xu, J.; Zheng, W*., Insulin‐like growth factor‐1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone‐induced oxidative injury. British Journal of Pharmacology 2018, 175 (1), 125-139. IF 6.85
Afroz, R.; Cao, Y.; Rostam, M. A.; Ta, H.; Xu, S.; Zheng, W.; Osman, N.; Kamato, D.; Little, P. J., Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis. Pharmacology & therapeutics 2018, 187, 88-97. IF 10.6
Zheng, W*; Chong, C.-M.; Wang, H.; Zhou, X.; Zhang, L.; Wang, R.; Meng, Q.; Lazarovici, P.; Fang, J., Artemisinin conferred ERK mediated neuroprotection to PC12 cells and cortical neurons exposed to sodium nitroprusside-induced oxidative insult. Free Radical Biology and Medicine 2016, 97, 158-167. IF 6.34.
Liao, R.; Yan, F.; Zeng, Z.; Farhan, M.; Little, P.; Quirion, R.; Srivastava, L. K.; Zheng, W*., Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway. Molecular neurobiology 2017, 54 (9), 6931-6943. IF 6.17
Kamato, D.; Mitra, P.; Davis, F.; Osman, N.; Chaplin, R.; Cabot, P.; Afroz, R.; Thomas, W.; Zheng, W.; Kaur, H.; Brimble, M.; Little, P., Gaq proteins: molecular pharmacology and therapeutic potential. Cell Mol Life Sci, 2017, 74(8): 1379-1390. IF 6.721
Zeng, Z.; Wang, D.; Gaur, U.; Rifang, L.; Wang, H.; Zheng, W*., H2O2 attenuates IGF-1R tyrosine phosphorylation and its survival signaling properties in neuronal cells via NR2B containing NMDA receptor. Oncotarget 2017, 8 (39), 65313. IF 5.168
Zeng, Z.; Wang, X.; Bhardwaj, S. K.; Zhou, X.; Little, P. J.; Quirion, R.; Srivastava, L. K.; Zheng, W*., The atypical antipsychotic agent, clozapine, protects against corticosterone-induced death of PC12 cells by regulating the Akt/FoxO3a signaling pathway. Molecular neurobiology 2017, 54 (5), 3395-3406. IF 6.17
Yan, F.; Wang, H.; Gao, Y.; Xu, J.; Zheng, W*., Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage. ACS chemical neuroscience 2017, 8 (8), 1713-1723. IF 4.3
Wang, B.; Bao, S.; Zhang, Z.; Zhou, X.; Wang, J.; Fan, Y.; Zhang, Y.; Li, Y.; Chen, L.; Jia, Y.; Li, J.; Li, M.; Zheng, W., et al. A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer’s disease in Hong Kong Chinese population. Neurobiology of Aging 2018, 68, 160.e1-160.e7. IF 5.15
PJ, Little.; MD, Hollenberg.; D, Kamato.; W, Thomas.; J, Chen.; T, Wang.; Zheng, W.; N, Osman., Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR‐1 signalling. British journal of pharmacology 2016,173(20):2992-3000 IF 6.84.
Wang, H.; Farhan, M.; Xu, J.; Lazarovici, P.; Zheng, W*., The involvement of DARPP-32 in the pathophysiology of schizophrenia. Oncotarget 2017, 8(32), 53791-53803. IF 5.168
Wang, H.; Quirionc, R.; Littled, P. J.; Cheng, Y.; Feng, Z. P.; Sun, H.S.; Xu, J.; Zheng, W*, Forkhead box O transcription factors as possible mediators in the development of major depression. Neuropharmacology 2015, 99; 527-537. IF 5.03 (Invited review to WH)
Wang, H.; Zhang. Q; Wen, Q.; Lazarovici, P.; Jiang, H and Zheng, W*., Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway. Cell signal 2012, 24:17-24 IF 3.844 (“The 100 Most Influential International Academic Paper in China in 2012” by “Institute of Scientific and Technical information of China”, cited 105 times).
Zeng, ZW.; Wang, HT.; Fu, Shang.; Zheng, LH.; Peter, J.; Remi, Quirion and Zheng, W*., Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways [J] . Psychopharmacology, 2015, 1-10. IF 3.56
Wang, H.; Duan, X.; Ren, Y.; Liu, Y.; Huang, M.; Liu, P.; Wang, R.; Gao, G.; Zhou, L.; Feng, Z.; Zheng, W*., FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells. Mol Neurobiol 2013, 47(1):24-36. IF 5.73 (Major Research paper of the year by Glover medical study).
Zheng, W*.; Wang, H.; Zeng, Z.; Lin, J.; Little, P. J.; Srivastava, L. K,.; Quirion, R., The possible role of the Akt signaling pathway in schizophrenia. Brain Research 2012, 1470:145-158 IF 2.929 (Invited review to WH).
Burch, ML.; Zheng, W.; Little, PJ., Smad linker region phosphorylation in the regulation of extracellular matrix synthesis.Cell Mol Life Sci. 2011, 68:97-107. IF 7.04
Zheng, W.; Quirion, R., Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons. J Biol Chem 2009, 284:855-61. IF 4.279
Zheng, W.; Quirion R., Comparative intercellular signaling of IGF-1 and BDNF in hippocampal neurons and the role of PI3K/Akt pathway in cell survival. J. Neurochem 2004, 89:844-852. IF 4.834
Zheng, W.; Kar S, Quirion R., Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 (FoxO3a) is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons. Mol Pharmacol 2002, 62:225-233. IF 5.297
Zheng, W.; Kar, S.; Quirion R., Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 (FoxO3a) is mediated by Akt kinase in PC12 cells. J Biol Chem. 2000, 275:39152-39158. IF 7.258
Zheng, W.; Kar, S.; Quirion, R., Stimulation of protein kinase C modulates insulin-like growth factor-1-induced Akt activation in PC12 cells. J Biol Chem 2000, 275:13377-13385. IF 7.258
Bastianetto, S.; Zheng, W.; Quirion, R., Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons. British journal of pharmacology 2000, 131 (4), 711-720. IF 6.84
Zheng, W.; Bastianetto, S.; Mennicken, F.; Ma, W.; Kar, S., Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures. Neuroscience 2000,115 (1), 201-211. IF 3.504
Bastianetto, S.; Zheng, W.; Quirion, R., The Ginkgo biloba Extract (EGb 761) Protects and Rescues Hippocampal Cells Against Nitric Oxide‐Induced Toxicity: Involvement of Its Flavonoid Constituents and … Journal of neurochemistry 2000, 74 (6), 2268-2277. IF 4.87
Zheng, W.; Kar. S.; Quirion, R., FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling. Journal of neurochemistry 2002, 80 (6), 1049-1061 IF 4.89
Wang, H.; Lazarovici, P.; Zheng, W*., Forkhead box protein O, a family of transcription factors integrating diverse biological functions. Encyclopedia of Signaling Molecules, 2nd Edition 2018, 1821-1836 (Invited book for WH)