孟雪莲 - 辽宁大学

个人简介

孟雪莲，女，博士、教授、硕士生导师。2002年毕业于辽宁大学，获环境学学士学位，2005年毕业于辽宁大学，获环境科学硕士学位，2008年毕业于沈阳药科大学，获药理学博士学位。2008年至今，于辽宁大学从事药学研究及教学工作。主要从事防治神经退行性疾病的药物筛选及机制研究，抗炎免疫药理、抗自由基药理研究。主持“国家自然科学基金项目”、“辽宁省教育厅一般项目”、 “辽宁省科技厅优秀人才培育计划项目” 、“辽宁省科技厅自然科学基金项目” 、“辽宁省教育协会教改项目”、“辽宁大学青年科研基金项目”及多项横向科研课题的研究

研究领域

1.抗神经退行性疾病的药物筛选及作用机理研究 2.抗炎、抗肿瘤药理学研究

近期论文

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Meng XL, Chen ML, Chen CL, Gao CC, Li C, Wang D, Liu HS, Xu CB. Bisbenzylisoquinoline alkaloids of lotus (Nelumbo nucifera Gaertn.) seed embryo inhibit lipopolysaccharide-induced macrophage activation via suppression of Ca2+-CaM/CaMKII pathway. Food and Agricultural Immunology. 2019, 30(1): 878–896. Meng XL, Chen CL, Liu YY, Su SJ, Gou JM, Huan FN, Wang D, Liu HS, Ben SB, Lu J. Selenoprotein SELENOK Enhances the Migration and Phagocytosis of Microglial Cells by Increasing the Cytosolic Free Ca2+ Level Resulted from the Up-Regulation of IP3R. Neuroscience. 2019, 406: 38-49. Chen ML, Gou JM, Meng XL*, Chen CL, Liu XN. Cepharanthine, a bisbenzylisoquinoline alkaloid, inhibits lipopolysaccharide-induced microglial activation. Pharmazie. 2019, 74: 606-610. Meng XL, Zheng LC, Liu J, Gao CC, Qiu MC, Liu YY, Lu J, Wang D, Chen CL. Inhibitory effects of three bisbenzylisoquinoline alkaloids on lipopolysaccharide-induced microglial activation. RSC Advances. 2017, 7: 18347-18357. Meng XL, Zhang HL, Feng LL, Chen ML, Liu YY, Yu X, Huan FN, Lu J, Wang D, Liu HS, Chen CL. Selenoprotein SelK increases the secretion of insulin from MIN6 β cells. RSC Advances, 2017, 7: 35038-35047. Ma XP, Li XZ, Li WL, Wang D, Xu CB, Meng XL*. Identification and characterization of a cold-adapted and halotolerant nitrobenzene-degrading bacterium. RSC Advances. 2015, 5: 80276-80282. Xu CB, Gu JL, Ma XP, Dong T, Meng XL*. Investigation on the interaction of pyrene with bovine serum albumin using spectroscopic methods. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2014，125：391-395. Meng XL, Yang JY, Chen GL, Wang LH, Zhang LJ, Wang S, Li J, Wu CF. Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships. Chemico-Biological Interactions. 2008, 174: 51-59. Meng XL, Yang JY, Chen GL, Zhang LJ, Wang LH, Li J, Wang JM, Wu CF. RV09, a novel resveratrol analogue, inhibit NO and TNF-α production by LPS-activated microglia. International Immunopharmacology. 2008, 8: 1074-1082. Meng XL, Chen GL, Yang JY, Wang S, Wu CF, Wang JM. Inhibitory effect of a novel resveratrol derivative on nitric oxide production in lipopolysaccharide-activated microglia. Pharmazie, 2008, 63: 671-675.