陈曦 - 南方科技大学

个人简介

工作经历 2019 至今南方科技大学生物系助理教授 2016 至 2019 维康桑格研究所高级研究员 2013 至 2016 欧洲生物信息研究所博士后 2012 至 2013 曼彻斯特大学生命科学系研究助理学习经历 2009 至 2012 曼彻斯特大学生命科学系博士 2005 至 2009 北京大学医学部医学实验专业本科

研究领域

(1) 单细胞表观遗传以及转录组测序技术开发 (2) 基因组学数据的挖掘以及生物信息分析 (3) 以T细胞和干细胞为模型，研究转录因子以及染色质复合物在控制细胞命运决定以及记忆中的作用和机

近期论文

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Henriksson, J.*, Chen, X.*, Gomes, T., Ullah, U., and Meyer, K.B. (2019). Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation. Cell 176, 1–15. Zhang, W.*, Chronis, C.*, Chen, X.*, Zhang, H., Spalinskas, R., Pardo, M., Chen, L., Wu, G., Zhu, Z., Yu, Y., et al. (2019). The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell 24, 138–152.e8. Chen, X., Miragaia, R.J., Natarajan, K.N., and Teichmann, S.A. (2018). A rapid and robust method for single cell chromatin accessibility profiling. Nat. Commun. 9, 5345. Jia, G.*, Preussner, J.*, Chen, X.*, Guenther, S., Yuan, X., Yekelchyk, M., Kuenne, C., Looso, M., Zhou, Y., Teichmann, S., et al. (2018). Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. Nat. Commun. 9, 4877. Hagai, T., Chen, X., Miragaia, R.J., Rostom, R., Gomes, T., Kunowska, N., Henriksson, J., Park, J.-E., Proserpio, V., Donati, G., et al. (2018). Gene expression variability across cells and species shapes innate immunity. Nature 563, 197–202. Pramanik, J., Chen, X., Kar, G., Henriksson, J., Gomes, T., Park, J.-E., Natarajan, K., Meyer, K.B., Miao, Z., McKenzie, A.N.J., et al. (2018). Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Genome Med. 10, 76. Chen, X., Ji, Z., Webber, A., and Sharrocks, A.D. (2016). Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. Nucleic Acids Res. 44, 1566–1578. Yu, Y., Tsang, J.C.H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L.S., Lu, L., et al. (2016). Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 539, 102–106. Aguilar-Martinez, E., Chen, X., Webber, A., Paul Mould, A., Seifert, A., Hay, R.T., and Sharrocks, A.D. (2015). Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin. Proc. Natl. Acad. Sci. U. S. A. 112, E4854–E4863. Wiseman, E.F., Chen, X., Han, N., Webber, A., Ji, Z., Sharrocks, A.D., and Ang, Y.S. (2015). Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma. Mol. Cancer 14, 69. Chen, X., Müller, G.A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A.D., and Engeland, K. (2013). The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol. Cell. Biol. 33, 227–236. Chen, X., Teichmann, S.A., and Meyer, K.B. (2018). From Tissues to Cell Types and Back: Single-Cell Gene Expression Analysis of Tissue Architecture. Annu. Rev. Biomed. Data Sci. 1, 29-51. Chen, X., Love, J.C., Navin, N.E., Pachter, L., Stubbington, M.J.T., Svensson, V., Sweedler, J.V., and Teichmann, S.A. (2016). Single-cell analysis at the threshold. Nat. Biotechnol. 34, 1111–1118. Vieira Braga, F.A.*, Teichmann, S.A., and Chen, X.* (2016). Genetics and immunity in the era of single-cell genomics. Hum. Mol. Genet. 25, R141–R148.