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个人简介

工作经历 2014—至今,南方科技大学生物系,副教授 2007-2014, 中国科学院广州生物医药与健康研究院,研究员 1999-2007, 德国哥廷根大学医学院博士后 1989-1995, 西北师范大学生物系,助教、讲师 教育背景 1999年,获德国Essen大学动物生理系博士学位 1989年,获西北师范大学生物系硕士学位 1986年,获西北师范大学生物系学士学位

研究领域

1. 胰腺发育与再生的分子机理 2. 癌症动物模型

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Shi, Z., Xin, H., Tian, D., Lian, J., Wang, J., Liu, G., Ran, R., Shi, S., Zhang, Z., Shi, Y., Deng, Y., Hou, C., and Chen, Y. 2019. Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system. FASEB J. 33, 6962-6968. 2. Shi, Z., Tian, D., Xin, H., Lian, J., Guo, X., and Chen, Y. 2017. Targeted integration of genes in Xenopus tropicalis. Genesis 55(1-2). 3. Shi, Z., Wang, F., Cui, Y., Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., and Chen, Y. 2015. Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis. FASEB J.29, 4914-4923. 4. Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., and Chen, Y. 2014. Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development 141, 707-714. 5. Zhao, H., Han, D., Dawid, I.B., Pieler, T., and Chen, Y. 2012. Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos. Proc. Natl. Acad. Sci. U S A. 109,8594-8599. 6. Lei, Y., Guo, X., Liu, Y., Cao, Y., Deng, Y., Chen, X., Cheng, C.H., Dawid, I.B., Chen, Y., and Zhao, H. 2012. Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc. Natl. Acad. Sci. U S A. 109, 17484-17489. 7. Wen, L., Yang, Y., Wang, Y., Xu, A., Wu, D., and Chen, Y. 2010. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Dev. Dyn. 239, 2198-2207. 8. Afelik, S., Chen, Y. and Pieler, T. 2006. Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. Genes Dev. 20, 1441-1446. 9. Chen, Y., Pan, F. C., Brandes, N., Afelik, S., Sölter, M. and Pieler, T. 2004. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev. Biol. 271, 144-160. 10. Hollemann, T., Chen, Y., Grunz, H. and Pieler, T. 1998. Regionalized metabolic activity establishes boundaries of retinoic acid signalling. EMBO J. 17, 7361-7372.

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