魏志毅 - 南方科技大学

个人简介

工作经历 2013年至今，南方科技大学生物系, 副教授/实验室PI， 2009 – 2013年，香港科技大学生命科学部, 研究助理教授 2007 – 2009年，华盛顿大学（美国西雅图）医学院, 博士后研究员学习经历博士，生物化学与分子生物学，中国科学技术大学，2007年学士，生物学，中国科学技术大学，2002年

研究领域

疾病相关的神经发育的分子机制功能性膜结构域的组装机制胞内运输机制蛋白质机器

近期论文

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Li,H.*,Deng,Y.*,Sun,K.,Yang,H.,Liu,J.,Wang,M.,Zhang,Z.,Lin,J.,Wu,C.#,Wei,Z.#,Yu,C.# (2017) Structural basis of kindlin-mediated integrin recognition and activation. Proc Natl Acad Sci U S A. published ahead of print July 24, 2017,doi: 10.1073/pnas.1703064114 （2017） Wei ZY*, Xu ZW* et al. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase. Nucleic Acids Res. Feb 18;44(3):1247-55（2016） Zhao HT, Sheng G, Wang J, Wang M, Bunkoczi G, Gong WM, Wei ZY#, Wang YL#. Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli. Nature. 515:147-150 (2014) Li YJ*, Wei ZY*, Yan Y, Wan Q, Du QS, Zhang MJ. Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. Proc Natl Acad Sci USA. 111:17444-17449. (2014) Wang C*, Wei ZY*, Chen KY, Ye F, Yu C, Bennett V, Zhang MJ. Structural basis of diverse membrane target recognitions by ankyrins. Elife. 3. (2014) Wei ZY#, Liu XT, Yu C, Zhang MJ#. Structural basis of cargo recognitions for class V myosins. Proc Natl Acad Sci USA.110: 11314-11319. (2013) Wang C, Yu C, Ye F, Wei ZY#, Zhang MJ#. Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function. Proc Natl Acad Sci USA. 109:4822-4827 (2012) Wei ZY, Zheng SL, Spangler SA, Yu C, Hoogenraad C, Zhang MJ. Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures. Mol Cell. 43:586-598 (2011) Wei ZY, Yan J, Lu Q, Pan LF, Zhang MJ. Cargo Recognition Mechanism of Myosin X Revealed by the Structure of its Tail MyTH4-FERM Tandem in Complex with the DCC P3 Domain. Proc Natl Acad Sci USA. 108:3572-3577 (2011) Wu L, Pan LF, Wei ZY, Zhang MJ. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science. 331:757-60 (2011) Liu W, Wen WY, Wei ZY, Yu J, Ye F, Liu CH, Hardie RC, Zhang MJ. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Cell. 145:1088-1101 (2011) Cheng ZH, Biechele T, Wei ZY, Morrone S, Moon RT, Wang LG, Xu WQ. Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol. 18:1204-1210 (2011) Wang R*, Wei ZY*, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen ZL, Zhang MJ. Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor. Mol Cell. 27: 692-703 (2009) Yu C, Feng W, Wei ZY, Miyanoiri Y, Zhao YX, Zhang MJ. Myosin VI Undergoes Cargo-Mediated Dimerization. Cell. 138: 537-548 (2009)