姬生健 - 南方科技大学

个人简介

工作经历 2014-现在南方科技大学生物系，副教授 2008-2014 美国康乃尔大学威尔医学院药理学系历任博士后，research associate，研究助理教授（faculty） 2003-2007 美国约翰-霍普金斯大学医学院神经科学系博士后学习经历 1994-1998 烟台大学生物化学系生物化学专业学士 1998-2003 北京大学生命科学学院生物化学与分子生物学专业博士

研究领域

各种信号传导途径，特别是神经元轴突的靶组织激活的逆向信号途径，调控神经发育的分子机制。 mRNA在轴突中的局部翻译控制神经发育和再生的机制。 mRNA的转录后调控控制神经系统发育的机理

近期论文

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Mengru Zhuang, Xinbei Li, Junda Zhu, Jian Zhang, Fugui Niu, Fanghao Liang, Mengxian Chen, Duo Li, Peng Han, Sheng-Jian Ji*. The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Research 2019, doi: 10.1093/nar/gkz157. Published online Mar 7th, 2019. Jun Yu#, Mengxian Chen#, Haijiao Huang#, Junda Zhu, Huixue Song, Jian Zhu, Jaewon Park, Sheng-Jian Ji*. Dynamic m6A modification regulates local translation of mRNA in axons. Nucleic Acids Research 2018, 46(3): 1412-1423. Published online Nov 23rd, 2017. Sheng-Jian Ji, Samie R. Jaffrey*. Axonal transcription factors: Novel regulators of growth cone-to-nucleus signaling. Developmental Neurobiology 2014, 74(3): 245-258. Dilek Colak, Sheng-Jian Ji, Bo Torben Porse, Samie R. Jaffrey*. Regulation of axon guidance by nonsense-mediated mRNA decay. Cell 2013, 153(6): 1252-1265. Sheng-Jian Ji, Samie R. Jaffrey*. Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron 2012, 74(1): 95-107. Breset A. Walker#, Sheng-Jian Ji#, Samie R. Jaffrey*. Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG. Journal of Neuroscience 2012, 32(41): 14442-14447. Sheng-Jian Ji, Goran Periz, Shanthini Sockanathan*. Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities. Development 2009, 136 (2): 231-240. Sheng-Jian Ji#, Binquan Zhuang#, Crystal Falco, André Schneider, Karin Schuster-Gossler, Achim Gossler, Shanthini Sockanathan*. Mesodermal and neuronal retinoids regulate the induction and maintenance of forelimb spinal motor neuron subtype identity. Developmental Biology 2006, 297(1): 249-261. Sheng-Jian Ji, Ying-Chun Lu, Jian-Xun Feng, Gang Wei, Jun Li, Yong-Hui Shi, Qiang Fu, Di Liu, Jing-Chu Luo, Yu-Xian Zhu*. Isolation and analyses of genes preferentially expressed during early cotton fiber development by subtractive PCR and cDNA array. Nucleic Acids Research 2003, 31(10): 2534-2543. Sheng Jian Ji, Feng Liu, Er Qiu Li, Yu Xian Zhu*. Recombinant scorpion insectotoxin AaIT kills specifically insect cells but not human cells. Cell Research 2002, 12(2): 143-150. Shengjian Ji, Yingchun Lu, Jun Li, Gang Wei, Xiujuan Liang, Yuxian Zhu*. A b-tubulin-like cDNA expressed specifically in elongating cotton fibers induces longitudinal growth of fission yeast. Biochemical and Biophysical Research Communications 2002, 296(5): 1245-1250. Jian-Xun Feng, Sheng-Jian Ji, Yong-Hui Shi, Yu Xu, Gang Wei, Yu-Xian Zhu*. Analysis of five differentially expressed gene families in fast elongating cotton fiber. Acta Biochimica et Biophysica Sinica 2004, 36(1): 51-57.