研究领域
1）杀虫基因cry基因和相关代谢途径的表达调控。建立了芽胞期重要转录因子的突变体，并利用这些遗传材料明确了cry1Ac和cry8Ea基因的转录调控机制，为新型杀虫微生物制剂的研制提供了表达元件及思路。重点研究了Bt Sigma54因子控制的代谢途径相关基因簇的表达调控，发现了一些特殊的表达调控机制，丰富了对这一领域的认识，同时为从代谢途径角度提高Cry蛋白产量奠定了基础。 2）Bt的遗传与发育研究。重点针对Cry蛋白在田间应用中紫外辐射失活的问题，从芽胞形成晚期调控网络入手，解析母细胞的裂解机制，已发现一种相关水解酶，为通过遗传改造阻断母细胞裂解，从而保护晶体（Cry蛋白）提供了理论基础。同时发现一株具有特殊表型的苏云金芽胞杆菌菌株，其产晶体在非芽胞细胞中，它的分化及cry基因的表达调控机制的解析将为新型制剂研制开辟新的途径，同时丰富对原核细胞分化的认识。 3）Bt与害虫互作研究。通过转录组和蛋白组分析Bt在侵染害虫过程中特异表达基因，发现其适应宿主、生存竞争及毒力相关机制
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Chao Deng, Leyla Slamti, Ben Raymond, Guiming Liu, Christelle Lemy, Myriam Gominet, Jingni Yang, Hengliang Wang, Qi Peng, Jie Zhang, Didier Lereclus*, Fuping Song*. (2014) Division of labour and terminal differentiation in a novel Bacillus thuringiensis strain. 2014. The ISME Journal. doi:10.1038/ismej.2014.122. IF=8.9
Changmei Zhou, Qi Peng, Lixin Du, Changlong Shu, Jie Zhang, Fuping Song*. (2014) Screening of cry-type promoters with strong activity and application in Cry protein encapsulation in a sigK mutant. Applied Microbiology and Biotechnology. doi:10.1007/s00253-014-5874-5. IF=3.4
Zhe Zhang, Min Yang, Qi Peng, Jie Zhang, Fuping Song*. (2014) Transcription of the lysine-2,3-aminomutase gene at the kam locus of Bacillus thuringiensis subsp. kurstaki HD73 is controlled by both Sigma54 and SigmaK factor. Journal of Bacteriology. doi: 10.1128/JB.01675-14. IF=3.9
Guiming Liu, Chao Deng, Lai Song, Qi Peng, Jie Zhang，Didier Lereclus and Fuping Song*. 2014. Draft Genome Sequence of Bacillus thuringiensis strain LM1212 isolated from the cadaver of an Oryctes gigas larva in Madagascar. Genome announcements. 2014 May 29;2(3). pii: e00516-14. doi: 10.1128/genomeA.00516-14.
Changlong Shu, Jingtao Zhang, Guihua Chen, Gemei Liang, Kanglai He, Neil Crickmore,Dafang Huang, Jie Zhang*, Fuping Song*. (2013) Use of a pooled clone method to isolate a novel Bacillus thuringiensis Cry2A toxin with activity against Ostrinia furnacalis. Journal of Invertebrate Pathology 114 (2013) 31–33. IF=2.6
Jingni Yang, Qi Peng, Zhen Chen, Chao Deng, Changlong Shu, Jie Zhang, Dafang Huang, Fuping Song*. (2013) Transcriptional Regulation and Characteristics of a Novel N-acetylmuramoyl-L-alanine Amidase Gene Involved in Bacillus thuringiensis Mother Cell Lysis. Journal of Bacteriology (195): 2887-2897. IF=3.9
Changlong Shu, Huiqin Su, Jie Zhang, Kanglai He, Dafang Huang,Fuping Song*. (2013) Characterization of cry9Da4, cry9Eb2, and cry9Ee1genes from Bacillus thuringiensis strain T03B001. Applied Microbiology and Biotechnology 97(22):9705-13. IF=3.4
Guiming Liu, Lai Song, Changlong Shu, Pinshu Wang, Chao Deng, Qi Peng, Didier Lereclus, Xumin Wang, Dafang Huang, Jie Zhang, Fuping Song*.(2013) Complete Genome Sequence of Bacillus thuringiensis subsp. kurstakiStrain HD73. Genome announcements. 01/2013; 1(2):e0008013.
Song Fuping*, Peng Qi, Brillard, J., Buisson, C., de Been, M., Abee, T., Broussolle, V., Huang Dafang, Zhang Jie, Lereclus, D., and Nielsen-Leroux, C*. (2012) A multicomponent sugar phosphate sensor system specifically induced in Bacillus cereus during infection of the insect gut. FASEB J . 26, 3336-3350. IF=5.7
Du Lixin, Qiu Lili, Peng Qi, Lereclus Didier, Zhang Jie, Song Fuping*,and Huang Dafang*. (2012) Identification of the promoter in the intergenic region between orf1 and cry8Ea1 controlled by Sigma H factor. Appl Environ Microbiol. 78, 4164-4168. IF=3.8
Yang Hui, Wang Pinshu, Peng Qi, Rong Rong, Liu, Chunxia, Lereclus Didier, Zhang Jie, Song Fuping*, and Huang Dafang* (2012) The cry1Ac gene is weakly transcribed in non-sporulating Bacillus thuringiensis cells. Appl Environ Microbiol. 78(18): p. 6466-74. IF=3.8
Yang Hui, Song Fuping*, Zhang Jie, Huang Dafang*. In vivofluorescence observation of parasporal inclusion formation in Bt. SCIENCE CHINA Life Sciences. 2010. 53(9): 1106-1111. IF=1.6
Li Zhu, Qi Peng, Fuping Song*, Yanan Jiang, Changpo Sun, Jie Zhang and Dafang Huang*. 2010. The structure and regulation of the gab gene cluster involved in the GABA shunt controlled by a σ54 2 factor in Bacillus thuringiensis. Journal of Bacteriology. 192(1): 346-355. IF=3.8
Changlong Shu, Guixin Yan, Rongyan Wang, Jie Zhang, Dafang Huang,Fuping Song*. 2009. Characterization of a novel cry8 gene specific to Melolonthidae pests: Holotrichia oblita. Appl Microbiol Biotechnol. 84: 701–707. IF=3.4
Changlong Shu, Hong Yu, Rongyan Wang, Shuliang Fen, Xudong Su, Dafang Huang, Jie Zhang, Fuping Song*. 2008. Characterization of two novel cry8 genes from Bacillus thuringiensis Strain BT185. Current Microbiology.58: 389-392. IF=1.8
Shu C., Zhang J., Huang D., Song F*. 2007. Improving toxicity ofBacillus thuringiensis strain contains the cry8Ca gene specific to Anomala corpulenta larvae. Current Microbiology, 55: 492-496. IF=1.8
Liu J., Zhang J., Huang D., Song F*. 2007. Identification of vip3A-type genes from Bacillus thuringiensis strains and characterization of a novel vip3A-type gene. Letters in Applied Microbiology, 45: 432–438. IF=1.6
Su XuDong, Shu ChangLong, Zhang Jie, Huang DaFang, Tan JianXin,Song FuPing*, 2007, Identification and Distribution of Bacillus thuringiensisIsolates from Primeval Forests in Yunnan and Hainan Provinces and Northeast Region of China, Agricultural Sciences in China, 6(11):1345-1351. IF=0.4
Hong Yu, Jie Zhang, Dafang Huang, Jiguo Gao, Fuping Song*. 2006. Characterization of Bacillus thuringiensis strain Bt185 toxic to the Asian cockchafer: Holotrichia parallela. Current Microbiology. 53:13-17. IF=1.8
Fuping Song, Jie Zhang, Dafang Huang et al. 2003. Identification ofcry1I-type genes from Bacillus thuringiensis strains and charaterization of a novel cry1I-type gene. Applied and Environmental Microbiology. 69(9): 5207-5211. IF=3.8
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