张智军 - 中国科学院苏州纳米技术与纳米仿生研究所 -

个人简介

1984年和1987年在西北大学分获学士和硕士学位。1998－1999年北京大学化学与分子工程学院，博士后。1999－2001年日本名古屋大学物质科学国际研究中心，日本学术振兴会（JSPS）特别研究员。2001－2004年在加拿大国家研究院Steacie分子科学研究所，NSERC研究员。2004-2005年在加拿大McGill大学生物医学工程系，研究助理。2006-2007在加拿大国家研究院工业材料研究所，研究助理。2007年底回国受聘中国科学院苏州纳米技术与纳米仿生研究所研究员、课题组长。目前任纳米生物医学研究部副主任，苏州纳米所学位委员会委员，中国毒理学会理事，江苏省侨界专家委员会委员。担任JACS, Adv. Mater.等30多个国际学术刊物的审稿人，以及捷克国家科技基金会、葡萄牙国家科技基金会和香港研究资助局等海外基金评审专家。回国后先后承担了国家自然科学基金、国家科技部973重大研究计划以及中国科学院重点部署项目等科研课题。长期从事纳米材料的制备及其在生物医学等领域的应用研究。在Nature Materials, Nano Letters, Advanced Materials以及Biomaterials等国际学术刊物发表论文60余篇，引用2300余次。获美国专利1项、中国专利7项。

研究领域

（1）新型纳米载药系统和纳米诊疗一体化平台的构建。（2）纳米支架材料用于调控干细胞自我更新与定向分化的研究。（3）纳米生物学效应

近期论文

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49. Ma, Y. F.; Huang, J.; Song, S. J.; Chen, H. B.*; Zhang, Z. J.* Cancer-Targeted Nanotheranostics: Recent Advances and Perspectives (Invited Review), Small, 2016, accepted. 48. Tu, X. L.; Wang, L. N.; Jin, W.; Wang, B.; Tang, Y. D.; Shi, J.; Zhang, Z. J.; Chen, Y.* 3D printed PEGDA microstructures for gelatin scaffold integration and neuron differentiation, Microelectronic Engineering, 2016, accepted. 47. Ma, Y. F.; Wang, H. M., Yan, D.; Wei, Y. Q.; Cao, Y. H.; Yi, P. W.; Zhang, H. L.; Deng, Z. W.; Dai, J. W.; Liu, X. T.; Luo, J. X.; Zhang, Z. J.;* Sun, S. Q.;* Guo, H. C.* Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2, Sci. Rep., 2016, 6, 23392; doi: 10.1038/ srep23392. 46. Liang, H.; Li, X. R.; Wang, B.; Chen, B.; Zhao, Y. N.; Sun, J.; Zhuang, Y.; Shen, H.; Zhang, Z. J.; Dai, J. W.* A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix, Sci. Rep. 2016, 6, 18205, doi: 10.1038/srep18205. 45. Tu, X. L.; Wang, L. N.; Cao, Y. H.; Ma, Y. F.; Shen, H.; Zhang, M. X; Zhang, Z. J.* Efficient cancer ablation by combined photothermal and enhanced chemo- therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites, Carbon, 2016, 97, 35-44. 44. Shen, H.; Liu, M.; Zhang, Z. J.* Biodegradable poly(aminoester)-mediated p53 gene delivery for cancer therapy, J. Nanosci. Nanotechnol. 2016, 16, 2210-2217. 43. Zhang, Y.; Shen, T. T.; Deng, X.; Ma, Y. F.; Wang, L. N.; Peng, Y.; Wu, J.; Zhang, Z. J.; Liu, W. S.; Tang, Y. Design of a versatile nanocomposite for ‘seeing’ drug release and action behaviour, J. Mater. Chem. B, 2015, 3, 8449-8458. (Front cover) 42. Shen, H.; Ma, Y. F.; Luo, Y.; Liu, X. Y.; Zhang, Z. J.*; Dai, J. W.* Directed osteogenic differentiation of mesenchymal stem cell in three-dimensional biodegradable methylcellulose-based hydrogel scaffold, Colloids and Surfaces B: Biointerfaces, 2015, 135, 332-338. 41. Liang, H.; Li, X. R.; Chen, B.; Wang, B.; Zhao, Y. N.; Zhuang, Y.; Shen, H.; Zhang, Z. J.; Dai, J. W*. A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy, J. Controlled Release, 2015, 209, 101-109. 40. Huang, J.; Guo, M.; Ke, H. T.; Zong, C.; Ren, B.*; Liu, G.; Shen, H.; Ma, Y. F.; Wang, X. Y.; Zhang, H. L.; Deng, Z. W.; Chen, H. B.*; Zhang, Z. J.* Rational design and synthesis of magnetic gold nanoflowers for efficient cancer theranostics, Advanced Materials, 2015, 27, 5049-5056. 39. Luo, Y.; Shen, H.; Fang, Y. X.; Cao, Y. H.; Huang, J.; Dai, J. W.*; Shi, X. Y.*; Zhang, Z. J.* Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on electrospun graphene oxide-incorporated poly (lactic-co-glycolic acid) nanofibrous mats, ACS Appl. Mater. Interfaces, 2015, 7, 6331–6339. 38. Song, S. J.; Ma, Y. F.*; Shen, H.; Zhang, M. X.; Zhang, Z. J.*, Removal and recycling of ppm level methylene blue from natural water with graphene oxide, RSC Advances, 2015, 5, 27922 - 27932. 37. Zhang, M. X.; Cao, Y. H.; Wang, L. N.; Ma, Y. F.; Tu, X. L.; Zhang, Z. J*, Manganese doped iron oxide theranostic nanoparticles for combined T1 magnetic resonance imaging and photothermal therapy, ACS Appl. Mater. Interfaces, 2015, 7, 4650-4658. 36. Huang, J.; Wu, Y. J.; Wang, D. D.; Ma, Y. F.; Yue, Z. K.; Lu, Y. T.; Zhang, M, X.; Zhang, Z. J.; Yang, P.* Silicon phthalocyanine covalently functionalized N-doped ultra-small reduced graphene oxide decorated with Pt nanoparticles for hydrogen evolution from water, ACS Appl. Mater. Interfaces, 2015, 7, 3732–3741. 35. Guo, M.; Huang, J.; Shen, H.: Ma, Y. F.; Zhang, M. X.; Zhu, A.; Li, Y. L.; He, H.; Wang, Y. Y.; Tian, X.; Ge, C. C.; Zhang, Z. J.;* Chen, H. B.* Near-infrared fluorescent cyanine-grafted graphene oxide with enhanced intrinsic photothermal performance for in vivo tumor eradication (Frontispiece), Advanced Functional Materials, 2015, 25, 59–67. 34. Ding, Z. J.; Zhang, Z. J.; Ma, H. W.; Chen, Y. Y. In vitro hemocompatibility and toxic mechanism of graphene oxide on human peripheral blood T lymphocytes and serum albumin, ACS Appl. Mater. & Interfaces, 2014, 6, 19797-19807. 33. Ding, X. G.; Liow, C.; Zhang, M. X.; Huang, R. J.; Li, C. Y.; Shen, H.; Liu, M. Y.; Zou, Y.; Gao, N.; Zhang, Z. J.; Li, Y. G.; Wang, Q. B.; Li, S. Z.; Jiang, J. Surface plasmon resonance enhanced light absorption and photothermal therapy in the second near-infrared window, J. Am. Chem. Soc., 2014, 136, 15684-15693. 32. Cao, Y. H.; Ma, Y. F.; Wang, H. M.; Zhang, M. X.; Tu, X. L.; Shen, H.; Dai, J. W.; Guo, H. C.; Zhang, Z. J.* Ultra-small graphene oxide-supported gold nanoparticles as adjuvant improves humoral and cellular immunity in mouse, Advanced Functional Materials, 2014, 24, 6963–6971. 31. Xiao, Q. B.; Li, Y. F.; Li, F. J.; Zhang, M. X.; Zhang, Z. J.; Lin, H. Z.* Upconverting nanocomposite biosensors based on smart-polymer-switchable FRET: the case of efficient ratiometric temperature sensing using red/near-infrared dual emission, Nanoscale, 2014, 6, 10179-10186. 30. Ma, Y. F.; Shen, H,; Tu, X. L.; Zhang, Z. J.* Accessing in vivo toxicity of graphene materials: current methods and future outlook (Invited Review), Nanomedicine, 2014, 9, 1565-1580. 29. Liu, W. N.; Wen, S. H.; Jiang. L. Y.; An, X.; Zhang, M. X.; Wang, H.; Zhang, Z. J.; Zhang, G. X.*; Shi, X. Y.* PLGA hollow microbubbles loaded with iron oxide nanoparticles and doxorubicin for dual-mode US/MR imaging and drug delivery, Current Nanoscience, 2014, 10, 543-552. 28. Chong, Y.; Ma , Y. F.; Shen, H.; Zhou, X.; Xu, J. Y.; Fan, S. J.*; Zhang, Z. J.* In vitro and in vivo toxicity of graphene quantum dots, Biomaterials, 2014, 35, 5041-5048. 27. Zhang, L. M.; Xia, K.; Bai, Y. Y.; Lu, Z. X.; Tang, Y. J.; Deng, Y.; Chen, J.; Qian, W. P.; Shen, H.; Zhang, Z. J.; Ju, S. H.; He, N. Y.* Synthesis of Gold Nanorods and Their Functionalization with Bovine Serum Albumin for Optical Hyperthermia, J. Biomed. Nanotechnol. 2014, 10, 1440-1449. 26. Tu, X. L.; Ma, Y. F.; Cao, Y. H.; Zhang, M. X.; Zhang, Z. J.* PEGylated carbonnanoparticles for efficient in vitro photothermal cancer therapy, J. Mater. Chem. B, 2014, 2, 2184-2192 25. Zhang, M. X.; Cao, Y. H.; Chong, Y.; Zhang, H. L.; Deng, Z. W.; Hu, C. H.; Zhang, Z. J.* Graphene oxide based theranostic platform for T1-weighted magnetic resonance imaging and drug delivery, ACS Appl. Mater. Interface, 2013, 5, 13325-13332. 24. Shen, H.; Liu, M.; Chong, Y.; Huang, J.; Zhang, Z. J.* Synthesis, protein delivery, and in vitro and in vivo toxicity of a biodegradable poly(aminoester), Toxicology Research, 2013, 2, 379-387. 23. Cao, Y. H.; Chong, Y.; Shen, H.; Zhang, M. X.; Zhu, Y. M.; Zhang, Z. J.* Combination of TNF-α and Graphene Oxide-Loaded BEZ235 to Enhance Apoptosis of PIK3CA Mutant Colorectal Cancer Cells, J. Mater. Chem. B, 2013, 1, 5602-5610. 22. Huang, J.; Zong, C.; Shen, H.; Liu, X. J.; Ren, B.;* Zhang, Z. J.* Intracellular Tracking of Drug Release from Graphene Oxide by Surface-Enhanced Raman Spectroscopy, Nanoscale, 2013, 5, 10591-10598. 21. Liu, G.; Shen, H.; Mao, J. N.; Zhang, L. M.; Jiang, Z.; Sun, T.; Lan, Q.;* Zhang, Z. J.* Transferrin modified graphene oxide for glioma-targeted drug delivery: in vitro and in vivo evaluations, ACS Appl. Mater. Interfaces, 2013, 5, 6909-6914. 20.Wang, A. X.; Pu, K. F.; Dong, B.; Liu, Y.; Zhang, L. M.; Zhang, Z. J; Duan, W.; Zhu, Y. M.* Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells. Journal of Applied Toxicology, 2013, 33, 1156-1164. 19. Zhang, L. M.; Wang, Z. L.; Lu, Z. X.; Shen, H.; Huang, J.; Zhao, Q. H.; Liu, M.; He, N. Y.;* Zhang, Z. J.* PEGylated Reduced Graphene Oxide as a Superior ssRNA Delivery System, J. Mater. Chem. B，2013, 1, 749-755.（Front cover） 18. Shen, H.; Liu, M.; He, H. X.; Zhang, L. M.; Huang, J.; Chong, Y.; Dai, J. W.; Zhang, Z. J.* PEGylated Graphene Oxide-Mediated Protein Delivery for Cell Function Regulation, ACS Appl. Mater. & Interfaces, 2012, 4, 6317-6323. 17. Chen, W. H.; Cao, Y. H.; Liu, M.; Zhao, Q. H.; Huang, J.; Zhang, H. L.; Deng, Z. W.; Dai, J. W.; Williams, D. F.; Zhang, Z. J.* Rotavirus Capsid Surface Protein VP4-Coated Fe3O4 Nanoparticles: A Theranostic Nanoplatform for Efficient Cellular Imaging and Drug Delivery, Biomaterials, 2012, 33, 7895-7902. 16. Huang, J.; Zong, C.; Shen, H.; Liu, M.; Chen, B.; Ren, B.; Zhang, Z. J.*, Mechanism of Cellular Uptake of Graphene Oxide Studied by Surface-Enhanced Raman Spectroscopy, Small, 2012, 8, 2577-2584. 15. Zhang, L. M.; Xing, Y. D.; He, N. Y.; Zhang, Y.; Lu, Z. X.; Zhang, J. P.; Zhang, Z. J.* Preparation of Graphene Quantum Dots for Bioimaging Application, J.Nanosci. Nanotechnol. 2012, 12, 2924-2928. 14. Shen, H.；Zhang L. M.; Liu M.; Zhang, Z. J.* Biomedical Applications of Graphene (Review), Theranostics, 2012, 3(2), 283-294. 13. Liu, M.; Chen, B.; Huang, J.; Zhang, L. M.; Zhang, Z. J.* Polyamidoamine-Grafted Multiwalled Carbon Nanotubes for Gene Delivery: Synthesis, Transfection and Intracellular Trafficking, Bioconjugate Chem. 2011, 22, 2237-2243. 12. Chen, W. H.; Yi, P. W.; Zhang, Y.; Zhang, L. M.; Deng, Z. W.; Zhang, Z. J.* Composites of Aminodextran-Coated Fe3O4 Nanoparticles and Graphene Oxide for Cellular Magnetic Resonance Imaging, ACS Appl. Mater. Interfaces 2011, 3, 4085-4091. 11. Chen, B.; Liu, M.; Zhang, L. M.; Huang, J.; Yao, J. L.;* Zhang, Z. J.* Polyethylenimine- Functionalized Graphene Oxide as an Efficient Gene Delivery Vector, J. Mater. Chem. 2011, 21, 7736-7741. 10. 张燚, 陈彪, 杨祖培,* 张智军,* Fe3O4磁性纳米粒子-氧化石墨烯复合材料的可控制备及结构与性能表征,物理化学学报，2011, 27, 1261-1266. 9. Wang, L.; Wang, D.; Dong, X. Y.; Zhang, Z. J.; Pei, X. F.; Chen, X. J.; Chen, B.; Jin, J. Layered assembly of graphene oxide and Co-Al layered double hydroxide nanosheets as electrode materials for supercapacitors, Chem. Commun. 2011, 47, 3556-3558. 8. Zhao, Q. H.; Chen, W. H.; Chen, Y. D.; Zhang, L. M.; Zhang, J. P.; Zhang, Z. J.* Self-Assembled Virus-like Particles from Rotavirus Structural Protein VP6 for Targeted Drug Delivery, Bioconjugate Chem. 2011, 22, 346-352. 7. Zhang, Y.; Chen, B.; Zhang, L. M.; Huang, J.; Chen, F. H.; Yang, Z. P.; Yao, J. L.; Zhang, Z. J.* Controlled assembly of Fe3O4 magnetic nanoparticles on graphene oxide, Nanoscale 2011, 3, 1446-1450. (Top 10 most accessed articles in Nanoscale in February, 2011) 6. Zhang, L. M.; Lu, Z. X.; Zhao, Q. H.; Huang, J.; Shen, H.; Zhang, Z. J.* Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI–grafted graphene oxide, Small 2011, 7, 460-464. (Highlighted by Wiley-VCH MaterialsViewsChina, March 6, 2011). 5. 沈贺，张立明，张智军*，石墨烯在生物医学领域的应用（特邀综述）, 东南大学学报(医学版), 2011, 30, 218-223. 4. Chen, F. H.; Zhang, L. M.; Chen, Q. T.; Zhang, Y.; Zhang, Z. J.* Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell, Chem Comm. 2010, 46, 8633-8635. (Top 10 most accessed articles in Chem Comm in October, 2010) 3. Huang, J.; Zhang, L. M.; Chen, B.; Ji, N.; Chen, F. H.; Zhang, Y.; Zhang, Z. J.* Nanocomposites of size-controlled gold nanoparticles and graphene oxide: Formation and applications in SERS and catalysis, Nanoscale 2010, 2, 2733-2738. 2. Zhang, L. M.; Xia, J. G.; Zhao, Q. H.; Liu, L. W.; Zhang, Z. J.* Functional graphene oxide as nanocarriers for controlled loading and targeted delivery of mixed anticancer drugs, Small，2010, 6, 537-544. (Top 10 most accessed articles in Small in January, 2010). 1. Geng X. M.; Niu L.; Xing Z. Y.; Song R. S.; Liu G. T.; Sun M. T.; Cheng G. S.; Zhong H. J.; Liu Z. H.; Zhang Z. J.; Sun L. F.; Xu H. X.; Lu L.; and Liu L. W. Aqueous-processable noncovalent graphene and quantum dots composites for transparent and flexible optoelectronic films, Advanced Materials 2010, 22, 638-642. (Top 5 most accessed articles in Advanced Materials in December, 2009).