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个人简介

2014-至今,副教授,南京大学,医学院转化医学中心实验室主任 2013-2014,访问学者,美国哈佛大学,医学院 2008-2013,讲师/副研究员教授, 南京大学医学院 2006-2008,讲师,南京师范大学,生命科学学院分子细胞生物学研究所

研究领域

肝脏代谢类疾病机制研究,天然性药物筛选

近期论文

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1.Jia, W.-J., Jiang, S., Tang, Q.-L., Shen, D., Xue, B., Ning, W., and Li, C.-J. (2016) Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation. The American Journal of Pathology doi:10.1016/j.ajpath.2016.01.021 2.Lai, S.-S., Zhao, D.-D., Cao, P., Lu, K., Luo, O.-Y., Chen, W.-B., Liu, J., Jiang, E.-Z., Yu, Z.-H., and Lee, G , Gao X*, Li C-J*, Xue B* (2016) PP2Acα positively regulates the termination of liver regeneration in mice through the AKT/GSK3β/Cyclin D1 pathway. Journal of hepatology 64, 352-360(co-corresponding author) 3. Jiang, S., Shen, D., Jia, W. J., Han, X., Shen, N., Tao, W., Gao, X., Xue, B., and Li, C. J. (2016) GGPPS‐mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation. The Journal of pathology 238, 109-119(co-corresponding author) 4. Tao, W., Wu, J., Zhang, Q., Lai, S.-S., Jiang, S., Jiang, C., Xu, Y., Xue, B., Du, J., and Li, C.-J. (2015) EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription. Scientific reports DOI: 10.1038/srep15212 5. Tao, W., Wu, J., Xie, B.-X., Zhao, Y.-Y., Shen, N., Jiang, S., Wang, X.-X., Xu, N., Jiang, C., and Chen, S. Gao X, Xue B*, Li C-J*, (2015) Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway. Journal of Biological Chemistry 290, 20086-20097 (co-corresponding author) 6. Xu, N., Shen, N., Wang, X., Jiang, S., Xue, B., and Li, C-J. (2015) Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation. Science China Life Sciences 58, 328-335 7. Lai, S., Yuan, J., Zhao, D., Shen, N., Chen, W., Ding, Y., Yu, D., Li, J., Pan, F., and Zhu, M. Li C-J*, Xue B* (2015) Regulation of mice liver regeneration by early growth response-1 through the GGPPS/RAS/MAPK pathway. The international journal of biochemistry & cell biology 64, 147-154(co-corresponding author.) 8. Chen, W.-B., Lai, S.-S., Yu, D.-C., Liu, J., Jiang, S., Zhao, D.-D., Ding, Y.-T., Li, C.-J*., and Xue, B*. (2015) GGPPS deficiency aggravates CCl 4-induced liver injury by inducing hepatocyte apoptosis. FEBS letters 589, 1119-1126(co-corresponding author) 9. Shen, N., Jiang, S., Lu, J.-M., Yu, X., Lai, S.-S., Zhang, J.-Z., Zhang, J.-L., Tao, W.-W., Wang, X.-X., and Xu, N. Xue, B., and Li, C (2015) The constitutive activation of Egr-1/C/EBPa mediates the development of type 2 diabetes mellitus by enhancing hepatic gluconeogenesis. The American journal of pathology 185, 513-523(co-corresponding author) 10. Yu, D.-c., Liu, J., Chen, J., Shao, J.-j., Shen, X., Xia, H.-g., Li, C.-j., Xue, B*., and Ding, Y.-t*. (2014) GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis. BMC cancer 14, 248(co-corresponding author) 11. Lin, X., Zheng, W., Liu, J., Zhang, Y., Qin, H., Wu, H., Xue, B., Lu, Y., and Shen, P. (2013) Oxidative stress in malignant melanoma enhances Tumor Necrosis Factor-α secretion of tumor-associated macrophages that promote cancer cell invasion. Antioxidants & redox signaling 19, 1337-1355 12. Dai, G., Qian, Y., Chen, J., Meng, F.-L., Pan, F.-Y., Shen, W.-G., Zhang, S.-Z., Xue, B., and Li, C.-J. (2013) Calmodulin activation of polo-like kinase 1 is required during mitotic entry. Biochemistry and Cell Biology 91, 287-294 13. Tao, W., Shi, J.-F., Zhang, Q., Xue, B., Sun, Y.-J., and Li, C.-J. (2013) Egr-1 enhances drug resistance of breast cancer by modulating MDR1 expression in a GGPPS-independent manner. Biomedicine & Pharmacotherapy 67, 197-202 14. Lai, S.-S., Xue, B., Yang, Y., Zhao, L., Chu, C.-s., Hao, J.-y., and Wen, C.-j. (2012) Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE. Cancer genetics 205, 552-562(co-first author) 15. Shen, N., Shao, Y., Lai, S.-S., Qiao, L., Yang, R.-L., Xue, B., Pan, F.-Y., Chen, H.-Q., and Li, C.-J. (2011) GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation. The American journal of pathology 179, 2740-2750 16. Shen, N., Yu, X., Pan, F.-Y., Gao, X., Xue, B.*, and Li, C.-J*. (2011) An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. Journal of Biological Chemistry 286, 14508-14515(co-corresponding author) 17. Yu, X., Shen, N., Zhang, M. L., Pan, F. Y., Wang, C., Jia, W. P., Liu, C., Gao, Q., Gao, X., and Xue, B*. Li C-J*. .(2011) Egr‐1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. The EMBO journal 30, 3754-3765(co-corresponding author)

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