张秀莉 - 中国科学院大连化学物理研究所 -

研究领域

一直从事天然产物的分离分析与先导化合物的发现的研究工作。针对天然产物种类的多样性，建立了10万级的天然产物样品库；针对天然产物成分的复杂性，重点开展了二维液相色谱方法和寡糖极性物质分离方法研究；针对活性模型的多样性，重点开展了癌症、镇痛、心血管、痛风等重大疑难疾病的活性化合物的筛查和制备工作

近期论文

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Wang J.X., Wang C.R., Guo Z.M., Dong X.F., Xiao Y.S., Xue X.Y., Zhang X.L.?, Liang X.M.?, A novel method for characterization and comparison ofreversed-phase column selectivity, Journal of Chromatography A, xxx (2014) xxx–xxx. Zhang X.L., Deng H.Y., Xiao Y.S., Xue X.Y., Ferrie A.M., Tran E., Liang X.M.*, Fang Y. *,Label-free cell phenotypic profiling identifies pharmacologically active compounds in two traditional Chinese medicinal plants. RSC Advances, 2014, 4, 26368. Wang J.X., Kong S., Yan J.Y., Jin G.W., Guo G.M., Shen A.J., Xu X.Y., Zhang X.L.?, Zou L.J.?, Liang X.M. Hydrophilic interaction liquid chromatography-solid phase extraction directly combined with protein precipitation for the determination of triptorelin in plasma, Journal of Chromatography B, 960 (2014) 214–221. Guo X.J., Zhang X.L.?, Guo Z.M., Liu Y.F., Shen A.J., Jin G.W., Liang X.M. Hydrophilic interaction chromatography for selective separation ofisomeric saponins, Journal of Chromatography A, 1325 (2014) 121– 128. Zhang Y., Wang C.R., Wang L., Parks G.S., Zhang X.L., Guo G.M., Ke Y.X., Li K.W., Kim M.K., Vo B., Borrelli E., Ge G.B., Yang L., Wang Z.W., Garcia-Fuster M., Luo Z.D., Liang X.M. *, Civelli O*, A Novel Analgesic Isolated from a Traditional Chinese Medicine, Current Biology, 24, 117, 2014. Long Z., Guo Z.M., Xue X.Y., Zhang X.L.*, Nordahl L., Liang X.M.*, Selective separation and purification of highly polar basic compounds using a silica-based strong cation exchange stationary phase, Analytica Chimica Acta, ,804, 304, 2013. Xu J.Y., Zhang X.L.*, Guo Z.M., Yan J.Y., Yu L, Li X.L., Xue X.Y., Liang X.M.*, Orthogonal separation and identification of long-chain peptides from scorpion Buthus martensi Karsch venom by using two-dimensional mixed-mode reversed phase-reversed phase chromatography coupled to tandem mass spectrometry, Analyst, 138, 1835, 2013. Guo X.J., Zhang X.L.*, Feng J.T., Guo Z.M., Xiao Y.S., Liang X.M. *, Purification of saponins from leaves of Panax notoginseng using preparative two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography, Analytical and Bioanalytical Chemistry, 405(10), 3413, 2013. Wang C.R., Guo Z.M., Long Z., Zhang X.L.*, Liang X.M.*, Overloading study of basic compounds with a positively charged C18 column in liquid chromatography, Journal of Chromatography A, 1281, 60, 2013. Zhang Y., Xu J.Y., Wang Z.W., Zhang X.L, Liang X.M.*, Civelli O*, BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom, Plos One, 7(7), 1, 2012. Zeng, J., Zhang, X.L., Guo, Z.M., Feng, J.T., Xue, X.Y.*, Liang, X.M.*, Separation and identification of flavonoids from complex samples using off-line two-dimensional liquid chromatography tandem mass spectrometry, Journal of Chromatography A, 1220, 50,2012. Xu J.Y., Zhang X.L.*, Guo Z.M., Yan J.Y., Yu L, Li X.L.*, Xue X.Y., Liang X.M., Short-chain peptides identification of scorpion Buthus martensi Karsch venom by employing high orthogonal 2D-HPLC system and tandem mass spectrometry, Proteomics, 12(19-20, SI), 3076, 2012. Long Z., Wang C.R., Guo Z.M. *, Zhang X.L. Nordahl L., Liang X.M. *, Strong cation exchange column allow for symmetrical peak shape and increased sample loading in the separation of basic compounds, Journal of Chromatography A, 1256, 67,2012. Fu Q, Guo Z.M.*, Zhang X.L., Liu Y.F., Liang X.M.*, Comprehensive characterization of Stevia Rebaudiana using two-dimensional reversed-phase liquid chromatography/ hydrophilic interaction liquid chromatography, Journal of Separation Science, 35(14), 1821,2012. Cai X.M., Guo Z.M., Xue X.Y., Xu J.Y., Zhang X.L.*, Liang X.M., Two-dimensional liquid chromatography separation of peptides using reversed- phase/weak cation-exchange mixed-mode column in first dimension. Journal of Chromatography A, 1228, 242, 2012. Zhang X.L., Liu Y.F., Guo Z.M., Feng J.T., Dong J., Fu Q., Wang C.R., Xue X.Y., Xiao Y.S., Liang X.M., The herbalome—an attempt to globalize Chinese herbal medicine, Analytical and Bioanalytical Chemistry, 402,573,2012. Long Z., Wang C.R., Guo Z.M., Zhang X.L. Nordahl L., Zeng J., Zeng J.G,Liang X.M.*, A non-aqueous solid phase extraction method for alkaloid enrichment and its application in the determination of hyoscyamine and scopolamine. Analyst, 137, 1451,2012. Cai, X.M., Dong, J., Zou, L.J., Xue, X.Y., Zhang, X.L.*, Liang, X.M.*, Metabonomic Study of Lung Cancer and the Effects of Radiotherapy on Lung Cancer Patients: Analysis of Highly Polar Metabolites by Ultraperformance HILIC Coupled with Q-TOF MS, Chromatographia, 74, 391,2011. Cai, X. M.; Wang, C. R.; Xu, J. Y.; Xue, X. Y., Zhang, X. L.*;Liang, X. M. Application of matrix solid-phase dispersion methodology to the extraction of endogenous peptides from porcine hypothalamus samples for MS and LC-MS analysis Journal of Chromatography B 879,657,2011. Dong, J., Yu, L., Zhang, X.L., Xue, X.Y., Guo, Z.M.*, Liang, X.M.*, Protein separation on a polar-copolymerized C(8) stationary phase, Analytical and Bioanalytical Chemistry, 399,3415,2011.