董毅 - 中国医学科学院药物研究所 -

个人简介

教育背景 2003.09-2007.07 内蒙古大学，应用化学，学士 2007.09-2010.07 华南理工大学，应用化学，硕士 2011.09-2014.07 北京协和医学院，博士工作经历 2014.07-2016.07 清华大学药学院，博士后 2016.07-2018.09 中国医学科学院药物研究所，助理研究员 2018.09至今中国医学科学院药物研究所，副研究员

研究领域

1.趋化因子受体拮抗剂的设计、合成及活性评价 2.模式识别受体激动剂、拮抗剂的设计、合成、活性评价及相关应用 3.有机合成方法学研究

近期论文

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1. Y. Dong, X. Zhang, J. Chen, W. Zou, S. Lin, H. Xu*. Switching the site-selectivity of C–H activation in aryl sulfonamides containing strongly coordinating N-heterocycles. Chem. Sci. 2019, 10, 8744−8751 (cover paper). DOI: 10.1039/c9sc03691a 2. Y. Dong, S. Wang, C. Wang, Z. Li, Y. Ma*, G. Liu*. Antagonizing NOD2 signaling with conjugates of paclitaxel and muramyl dipeptide derivatives sensitizes paclitaxel therapy and significantly prevents tumor metastasis. J. Med. Chem. 2017, 60, 1219−1224. DOI: 10.1021/acs.jmedchem.6b01704 3. Y. Dong, J. Chen, Y. Cui, L. Bao, H. Xu*. Cp*RhIII-catalyzed sulfonamide-directed ortho arene C−H carbenoid functionalization with pyridotriazoles. Org. Lett. 2020, 22, 772−775 (cover paper). DOI: 10.1021/acs.orglett.9b03904 4. J. Yang, X. Hu, Z. Liu, X. Li, Y. Dong*, G. Liu*. Cp*CoIII-catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives. Chem. Commun. 2019, 55, 13840−13843. DOI: 10.1039/c9cc07173c 5. Y. Dong, J. Chen, H. Xu*, Rhodium(III)-catalyzed sulfonamide directed ortho C–H carbenoid functionalization via metal carbene migratory insertion. Chem. Commun. 2019, 55, 2027−2030 (cover paper). DOI: 10.1039/c8cc08837c 6. Y. Dong, J. Chen, H. Xu*, Rhodium(III)-catalyzed directed amidation of unactivated C(sp3)–H bonds to afford 1,2-amino alcohol derivatives. Chem. Commun. 2018, 54, 11096−11099 (cover paper). DOI: 10.1039/c8cc05637d 7. Y. Dong, G. Liu*. Auxiliary-assisted palladium-catalyzed direct C(sp3)−H sulfonamidation to afford 1,2-amino alcohol derivatives. J. Org. Chem. 2017, 82, 3864−3872. DOI: 10.1021/acs.joc.6b02975 8. Y. Dong, N. Du, X. Li, L. Zheng, G. Liu*. Tandem chloropalladation/cyclization and dearomative cyclization toward functionalized tricyclic bridged [3.2.1] skeleton compounds. Org. Lett. 2015, 17, 4110−4113. DOI: 10.1021/acs.orglett.5b02076 9. Y. Dong, G. Liu*. Rh-catalyzed sulfonic acid group directed ortho C–H olefination of arenes. Chem. Commun. 2013, 49, 8066−8068. DOI: 10.1039/c3cc44690e