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个人简介

简历 2019/01 –现在,中国科学院昆明植物研究所,植物化学与西部植物资源可持续利用国家重点实验室,研究员。 2010/07 -2018/12,中国科学院昆明植物研究所,植物化学与西部植物资源可持续利用国家重点实验室,助理研究员,副研究员。 2005/09-2010/06,天津大学,化学工程专业,硕士、博士 2000/09-2004/07,常州大学,化学工程与工艺专业,学士

研究领域

长期从事糖化学、糖类药物及糖生物材料的研发等相关基础及应用基础研究,在活性糖类天然产物的提取纯化及工艺优化、半合成修饰与改造、结构确证与质量研究、活性筛选评价与作用机制以及药代药效等研究方面积累了丰富研究经验,取得了系列原创性成果

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

[1] Xiao Zhang, Huiying Liu, Wang Yao, Lisha Lin, Jinhua Zhao, Mingyi Wu*, Zhongjun Li*, Synthesis of fucosylated chondroitin sulfate nonasaccharide as a novel anticoagulant targeting intrinsic factor xase complex, Angew. Chem. Int. Ed. 2018, 57: 12880–12885 [# first author, * Corresponding author] [2] Longyan Zhao(#), Mingyi Wu(#), Chuang Xiao, Lian Yang, Lutan Zhou, Na Gao, Zi Li, Jun Chen, Jianchao Chen, Jikai Liu*, Hongbo Qian*, Jinhua Zhao*, Discovery of an intrinsic tenase complex inhibitor: pure nonasaccharide from fucosylated glycosaminoglycan, Proc. Natl. Acad. Sci. USA, 2015, 112(27):8284–8289. [3] Li Xu(#), Na Gao(#), Chuang Xiao, Lisha Lin, Steven W. Purcell, Mingyi Wu*, Jinhua Zhao*, Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition, European Journal of Medicinal Chemistry, 2018, 154: 133–143. [4] Feineng Shang(#), Na Gao(#), Ronghua Yin, Lisha Lin, Chuang Xiao, Lutan Zhou, Zi Li, Steven W. Purcell, Mingyi Wu*, Jinhua Zhao*, Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors, European Journal of Medicinal Chemistry, 2018, 148: 423–435. [5] Xiao Zhang, Wang Yao, Xiaojiang Xu, Huifang Sun, Jinhua Zhao, Xiangbao Meng, Mingyi Wu*, Zhongjun Li*, Synthesis of fucosylated chondroitin sulfate glycoclusters: a robust route to novel anticoagulant agents, Chemistry–A European Journal, 2018, 24: 1694–1700. [6] Feineng Shang(#), Rongrong Mou(#), Zhidong Zhang(#), Na Gao, Lisha Lin, Zhongkun Li, Mingyi Wu*, Jinhua Zhao*, Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors, Carbohydrate Polymers, 2018, 195: 257–266. [7] Jie Liu, Lutan Zhou, Zhicheng He, Na Gao, Feineng Shang, Jianping Xu, Zi Li, Zengming Yang*, Mingyi Wu*, Jinhua Zhao*, Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica, Carbohydrate Polymers, 2018, 181: 433–441. [8] Ronghua Yin, Lutan Zhou, Na Gao, Zi Li, Longyan Zhao, Feineng Shang, Mingyi Wu*, Jinhua Zhao*, Oligosaccharides from depolymerized fucosylated glycosaminoglycan: structures and minimum size for intrinsic factor Xase complex inhibition, Journal of Biological Chemistry, 2018, 293: 14089–14099. [9] Lisha Lin, Li Xu, Chuang Xiao, Lutan Zhou, Na Gao, Mingyi Wu*, Jinhua Zhao*, Plasma contact activation by a fucosylated chondroitin sulfate and its structure-activity-relationship study, Glycobiology, 2018, 28: 754–764. [10] Wenjiao Yang, Ying Cai, Ronghua Yin, Lisha Lin, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber, International Journal of Biological Macromolecules, 2018, 115: 1055–1062. [11] Ying Cai, Wenjiao Yang, Ronghua Yin, Lutan Zhou, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer, Carbohydrate Research, 2018, 464: 12–18. [12] Xiaomei Li, Lan Luo, Ying Cai, Wenjiao Yang, Lisha Lin, Zi Li, Na Gao, Steven W. Purcell, Mingyi Wu*, Jinhua Zhao*,Structural elucidation and biological activity of a highly regular fucosylated glycosaminoglycan from the edible sea cucumber Stichopus herrmanni, Journal of Agricultural and Food Chemistry, 2017, 65: 9315–9323. [13] Jie Liu, Feineng Shang, Zengming Yang, Mingyi Wu*, Jinhua Zhao *, Structural analysis of a homogeneous polysaccharide from Achatina fulica, International Journal of Biological Macromolecules, 2017, 98: 786–792. [14] Chuang Xiao, Wu Lian, Lutan Zhou, Na Gao, Li Xu, Jun Chen, Mingyi Wu *, Wenlie Peng*, Jinhua Zhao*, Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors, Thrombosis Research, 2016, 146: 59–68. [15] Mingyi Wu, Li Xu, Longyan Zhao, Chuang Xiao, Na Gao, Lan Luo, Lian Yang, Zi Li, Lingyun Chen*, Jinhua Zhao*, Structural analysis and anticoagulant activities of the novel sulfated fucan possessing a regular well-defined repeating unit from sea cucumber. Marine Drugs, 2015, 13(4): 2063–2084. [16] Mingyi Wu (#), Dandan Wen (#), Na Gao, Chuang Xiao, Lian Yang, Li Xu, Wu Lian, Wenlie Peng, Jianmin Jiang*, Jinhua Zhao*, Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase, European Journal of Medicinal Chemistry, 2015, 92: 257–269. [17] Wu Lian (#), Mingyi Wu (#), Ning Huang, Na Gao, Chuang Xiao, Zi Li, Yongtang Zheng*, Wenlie Peng*, Jinhua Zhao*, Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope, Biochimica et Biophysica Acta, 2013, 1830: 4681–4691. [18] Lan Luo (#), Mingyi Wu (#), Li Xu, Wu Lian, Jiangying Xiang, Feng Lu, Na Gao, Jinhua Zhao*, Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers, Marine Drugs, 2013, 11: 399–417. [19] Mingyi Wu, Rong Huang, Dandan Wen, Na Gao, Jiangbo He, Zi Li, Jinhua Zhao *, Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas, Carbohydrate Polymers, 2012, 87(1): 862–868. [20] Na Gao (#), Mingyi Wu (#), Shao Liu, Wu Lian, Zi Li, Jinhua Zhao *, Preparation and characterization of O-acylated fucosylated chondroitin sulfate from sea cucumber, Marine Drugs, 2012, 10: 1647–1661. [21] Mingyi Wu, Shimin Xu, Jinhua Zhao*, Hui Kang, and Hui Ding, Physicochemical Characteristics and anticoagulant activities of low molecular weight fractions by free radical depolymerization of a fucosylated chondroitin sulfate from sea cucumber Thelenota ananas, Food Chemistry, 2010, 122(3): 716–723.

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