罗宏 - 中国科学院昆明植物研究所 -

个人简介

1994.9－1998.7 四川大学高分子材料，理学学士。 1998.8－2001.6 源兴电脑科技有限开发公司，电脑部件研发，研发组长。 2001.9－2006.7 云南大学微生物专业，理学博士。 2007.1－2015.7美国密歇根州立大学美国能源部植物研究所，资深助理研究员。 2015.9－至今中国科学院昆明植物研究所，副研究员

研究领域

基因组：通过多基因组与转录组的有机结合准确标定基因簇与合成基因岛等。基因功能：应用遗传学、生物化学和分子生物学等方法对基因功能进行研究。代谢途径解析与进化研究：综合应用各种方法确定基因在代谢中的功能与地位，确定代谢途径的整体运行规律，通过比较基因组与系统发育方法研究代谢途径的演化。人工环肽库：通过人工改变前体基因、操纵后修饰基因等方法构建大型功能环肽库，在此基础上筛选功能环肽

近期论文

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Lüli Y J, Cai Q, Chen Z H, Sun H, Zhu X T, Li X, Yang Z L, Luo H*. 2019. Genome of lethal Lepiota venenata and insights into the evolution of toxin-biosynthetic genes. BMC Genomics 20, 198. Luo H*, Cai Q, Lüli YJ, Li X, Sinha, R, Hallen HE, Yang, ZL. 2018. The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes. IMA Fungus 9(2): 225-242. H. Luo*, et al., 2015. Production of 15N-labeled α-amanitin in Galerina marginata. Toxicon，103，60-64 H. Luo, S. Y. Hong, R. M. Sgambelluri, E. R. Angelos, X. Li, and J. D. Walton. 2014. Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis. Chem. Biol. 21: 1610-1617 R. Riley, A. A. Salamova, D. W. Brown, L. G. Nagy, D. Floudas, B. W. Heldd, A. Levasseur, V. Lombardf, E. Moring, R. Otillar, E. A. Lindquist, H. Sun, K. M. LaButtia, J. Schmutz, h, D. Jabbour, H. Luo, S. E. Baker, A. G. Pisabarro, J. D. Walton, R. A. Blanchette, B. Henrissat, F. Martin, D. Cullen, D. S. Hibbett, and I. V. Grigoriev. 2014. Extensive sampling of basidiomycete genomes demonstrates inadequacy of the white-rot/brown-rot paradigm for wood decay fungi. Proc. Natl. Acad. Sci. USA 111: 9923-9928 R. M. Sgambelluri, S. Epis, D. Sassera, H. Luo, E. R. Angelos, and J. D. Walton. 2014. Profiling of amatoxins and phallotoxins in the genus Lepiota by liquid chromatography combined with UV Absorbance and mass spectrometry. Toxins 6: 2336-2347 J. D. Walton, H. Luo, and H. E. Hallen-Adams. 2012. Cyclic peptides from poisonous mushrooms. Method. Enzymol. 516: 63-76 H. Luo, H. E. Hallen-Adams, J. S. Scott-Craig, and J. D. Walton. 2012. Ribosomal biosynthesis of α-amanitin in Galerina marginata. Fung. Genet. Biol. 49: 123-129 H. Luo, H. E. Hallen-Adams, J. S. Scott-Craig, and J. D. Walton. 2010. Co-localization of amanitin and a candidate toxin-processing prolyl oligopeptidase in Amanita basidiocarps. Eukaryotic Cell 9: 1891-1900 J. D. Walton, H. E. Hallen-Adams, and H. Luo. 2010. Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms. Pept. Sci. 94: 659-664 H. Luo, H. E. Hallen, and J. D. Walton. 2009. Processing of the phalloidin proprotein by prolyl oligopeptidase from the mushroom Conocybe albipes. J. Biol. Chem. 284: 18070-18077 H. E. Hallen, H. Luo, J. S. Scott-Craig, and J. D. Walton. 2007. Gene family encoding the major toxins of lethal Amanita mushrooms. Proc. Natl. Acad. Sci. USA 104: 19097-19101 H. Luo, Y. J. Liu, L. Fang, X. Li, N. H. Tang, and K. Q. Zhang. 2007. Coprinus comatus damages nematode cuticles mechanically with spiny balls and produces potent toxins to immobilize nematodes. Appl. Environ. Microbiol. 73(12): 3916-3923 L. Li, M. Mo, Q. Qu, H. Luo, and K. Q. Zhang. 2007. Compounds inhibitory to nematophagous fungi produced by Bacillus sp. strain H6 isolated from fungistatic soil. Eur. J. Plant. Pathol. 117: 329-340 H. Luo, X. Li, Y. Pan, G. H. Li, and K. Q. Zhang. 2006. Acanthocytes of Stropharia rugosoannulata function as a nematode-attacking device. Appl. Environ. Microbiol. 72(4): 2982-2987 X. Li, H. Luo, and K. Q. Zhang. 2005. A new species of Harposporium parasitic on nematodes. Can. J. Bot. 83: 558-562 H. Luo, M. H. Mo, X. W. Huang, X. Li, and K. Q. Zhang. 2004. Coprinus comatus: A basidiomycete fungus forms novel spiny structures and infects nematodes. Mycologia 96: 1218-1225