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个人简介

2007.8-今: 中国科学院昆明植物研究所,研究员(2017.1起:二级研究员) 2004.10-2008.1: 德国马普化学生态研究所,博士后/洪堡学者 2004.3-2004.9:香港中文大学中医中药研究所,博士后 2001.9-2004.2:中国科学院昆明植物研究所,助研、副研 1996.9-2001.8:中国科学院昆明植物研究所,植物化学,博士 1992.9-1996.7:云南大学化学系,化学专业,学士

研究领域

植物天然产物化学、生物功能与生物合成:主要运用植物化学、分析化学、生物化学、细胞和分子生物学等手段,以及首创单细胞植物化学研究新技术方法LMD-cryoNMR-UPLC/MS/MS,揭示植物特殊结构(如腺毛、特定细胞等)中的天然产物及其生物功能,在此基础上发现独特天然活性物质,对具有新颖结构和重要生物功能的天然产物开展其生物合成和作用机理等研究。

近期论文

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Kai Guo, Yan Liu, Shihong Luo, Yanchun Liu, Desen Li, Wenyuan Li, Shenghong Li*. “Detoxification of plant aromatic abietanoids via cleavage of the benzene ring into 11,12-seco-diterpene polyenes by a specialist insect of Leucosceptrum canum”. Organic Letters, 2020, 22: 126-129. Hao Geng, Yanchun Liu, Desen Li, Chaojiang Xiao, Yan Liu, Xiaonian Li, Shenghong Li*. “Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides”. Phytochemistry, 2020, 173: 112325. Ting Tang, Chunhuan Li, Desen Li, Shuxi Jing, Juan Hua, Shihong Luo, Yan Liu*, Shenghong Li*. “Peltate glandular trichomes of Colquhounia vestita harbor diterpenoid acids that contribute to plant adaptation to UV radiation and cold stresses”. Phytochemistry, 2020, 172: 112285. Wenyuan Li, Yan Liu, Yutian Lin, Yanchun Liu, Kai Guo, Xiaonian Li, Shihong Luo*, Shenghong Li*. “Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis”. Phytochemistry, 2020, 170: 112198. Yan Liu, Shuxi Jing, Shihong Luo, Shenghong Li*. “Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis”. Natural Product Reports, 2019, 36: 626-665. Yonghong Chen, Jiangbo He, Xue Bai, Xiaonian Li, Lanfeng Lu, Yanchun Liu, Keqin Zhang*, Shenghong Li*, Xuemei Niu*. “Unexpected biosynthesis of fluorescein-like arthrocolins against resistant strains in an engineered Escherichia coli”. Organic Letters, 2019, 21: 6499-6503. Kai Guo, Yanchun Liu, Yan Liu, Shihong Luo, Wenyuan Li, Xiaonian Li, Shenghong Li*. “Diversified abietane family diterpenoids from the leaves of Leucosceptrum canum and their cytotoxic activity”. Phytochemistry, 2019, 157: 43-52. Fei Luo, Yi Ling, Desen Li, Ting Tang, Yanchun Liu, Yan Liu*, Shenghong Li*. “Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana”. Phytochemistry, 2019, 162: 121-128. Ling Feng, Yu Zhang, Yanchun Liu, Yan Liu, Shihong Luo, Chunshuai Huang, Shenghong Li*. “Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum”. Bioorganic & Medicinal Chemistry, 2019, 27: 442-446. Chunhuan Li, Jiayao Zhang, Xiuyun Zhang, Shenghong Li*, Jinming Gao*. “An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years”. European Journal of Medicinal Chemistry, 2019, 166: 400-416. Yi Ling, Linlin Teng, Juan Hua, Desen Li, Shihong Luo, Yanchun Liu, Yan Liu*, Shenghong Li*. “Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis”. Chinese Journal of Natural Medicines, 2019, 17: 0892-0899 Guowei Zheng, Shihong Luo, Shifei li, Juan Hua, Weiqi Li*, Shenghong Li*. “Specialized metabolites from Ageratina adenophora and their inhibitory activities against pathogenic fungi”. Phytochemistry, 2018, 148: 57-62. Yu Zheng, Chaojiang Xiao, Kai Guo, Ying Wang, Yan Liu, Shihong Luo, Xiaonian Li, Shenghong Li*. “Lobarioid A, unusual antibacterial depsidone possessing an eight-membered diether ring from the edible lichen Lobaria sp”. Tetrahedron Letters, 2018, 59: 743-746. Linlin Teng, Tianyang Song, Zifei Xu, Xiao Liu, Rong Dai, Yonghong Chen, Shenghong Li*, Keqin Zhang*, Xuemei Niu*. “Selected mutations revealed intermediates and key precursors in the biosynthesis of polyketide-terpenoid hybrid sesquiterpenyl epoxy-cyclohexenoids”. Organic Letters, 2017, 19: 3923-3926. Juan Hua, Yan Liu, Chaojiang Xiao, Shuxi Jing, Shihong Luo*, Shenghong Li*. “Chemical profile and defensive function of the latex of Euphorbia peplus”. Phytochemistry, 2017, 136: 56-64. Chaojiang Xiao, Yanchun Liu, Shihong Luo, Juan Hua, Yan Liu*, Shenghong Li*. “Localisation of two bioactive labdane diterpenoids in the peltate glandular trichomes of Leonurus japonicas by laser microdissection coupled with UPLC-MS/MS”. Phytochemical Analysis, 2017, 28: 404-409.6. Juan Hua, Shihong Luo, Yan Liu, Yanchun Liu, Yanyun Tan, Ling Feng, Chaojiang Xiao, Keqin Zhang*, Shenghong Li*, Xuemei Niu*. “New bioactive macrocyclic diterpenoids from Euphorbia helioscopia”. Chemistry & Biodiversity, 2017, 14: e1700327. (Cover Article) Yan Liu, Shihong Luo, Axel Schmidt, Jonathan Gershenzon, Guodong Wang, Guiling Sun, Marcus Grant, Ce Kuang, Minjie Yang, Shuxi Jing, Chunhuan Li, Bernd Schneider, Shenghong Li*. “A geranylfarnesyl diphosphate synthase provides the precursor for sesterterpenoid (C25) formation in the glandular trichomes of the mint species Leucosceptrum canum”. The Plant Cell, 2016, 28: 804-822. (Cover Article) Fengwei Ma, Bing Xia, Shihong Luo, Shenghong Li*, Yan Zhou*. “Analysis of the lithiated leucosceptroids from Leucosceptrum canum to facilitate their identification and differentiation by electrospray ionization tandem mass spectrometry”. Rapid Communications in Mass Spectrometry, 2016, 30 (Suppl. 1): 100-110. Ying Wang, Shihong Luo, Juan Hua, Yan Liu, Shuxi Jing, Xiaonian Li, Shenghong Li*. “Capitate glandular trichomes of Paragutzlaffia henryi harbor new phytotoxic labdane diterpenoids”. Journal of Agricultural and Food Chemistry, 2015, 63: 10004-10012.

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