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个人简介

1992年山东大学微生物系微生物学专业毕业,获理学学士学位;2001年北京大学生命科学院分子细胞生物学专业毕业,获理学博士学位;2001-2004年在美国哈佛大学医学院从事博士后研究工作;2004-2008年在美国德州大学西南医学中心从事博士后研究工作。2008年6月起任中科院上海生科院生物化学与细胞生物学研究所研究员,研究组长

研究领域

由细胞信号转导通路介导的对环境刺激的应答,不仅维持着细胞正常代谢,而且还决定了细胞生长、增殖、分化、机体发育等生命活动的方方面面,同时信号转导的异常也将导致人类各种严重疾病的发生,如发育疾病、癌症、代谢类疾病等等。Hedgehog(Hh)信号通路作为进化上最为保守的信号转导通路之一,控制了脊椎动物以及非脊椎动物众多发育过程中细胞的生长及分化,在人类发育和疾病发生发展中至关重要。本实验室综合利用细胞生物学、发育生物学、生物化学、分子生物学、遗传学等技术手段和方法,在分子、细胞及动物整体等多个层次研究Hh及其相关信号通路的分子机制在发育、干细胞干性维持、组织器官损伤修复及肿瘤发生发展中生物学功能

近期论文

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Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Jialin Fan, Hao Chen, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang and Yun Zhao*. UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing. EMBO Reports. 2017, e201643289. (*Corresponding author) Yuhong Han, Yue Xiong, Xuanming Shi, Jiang Wu, Yun Zhao* and Jin Jiang*. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. PLoS Biology. 2017, 15(8):e2002063. (*Corresponding author) Shuo Zhang, Chenyu Pan, Xiangdong Lv, Wei Wu, Hao Chen, Wenqing Wu, Hailong Wu, Lei Zhang, and Yun Zhao*. Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis. Scientific Reports. 2017, 7: 5101. (*Corresponding author) Xu Xiao, Jing-jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-ping Qiu, Yue Xiong, Lian-fang Yang, Hai-wei Cui, Xiao-long He, Lei Yin, Wei Qi, Catherine C.L. Wong, Yun Zhao, Bo-liang Li, Wen-wei Qiu and Bao-liang Song. Cholesterol modification of Smoothened is required for Hedgehog signaling. Molecular Cell. 2017, 66(1):154-162. Jiajun Xu, Xue Hao, Meng-Xin Yin, Yi Lu, Yunyun Jin, Jinjin Xu, Ling Ge, Wenqing Wu, Margaret Ho, Yingzi Yang, Yun Zhao and Lei Zhang. Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. Development. 2017, 144: 1510-1517. Yi Hao, Qinbo Zhou, Jing Ma, Yun Zhao, and Shusheng Wang. miR-146a is upregulated during retinal pigment epithelium (RPE)/choroid aging in mice and represses IL-6 and VEGF-A expression in RPE cells. J Clin Exp Ophthalmol. 2016, 7(3): 562. Lin Fu, Hailong Wu, Steven Y Cheng, Daming Gao, Lei Zhang and Yun Zhao*. Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway. eLIFE. 2016, 5:e15690. (*Corresponding author) Xiangdong Lv, Zhijun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Wei* and Yun Zhao*. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Research. 2016, 26:529-542. (*Corresponding author) Xiangdong Lv, Chenyu Pan, Zhao Zhang, Yuanxin Xia, Hao Chen, Shuo Zhang, Tong Guo, Hui Han, Haiyun Song, Lei Zhang and Yun Zhao*. SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis. Development. 2016, 143(10):1655-1662. (*Corresponding author) Shimin Wang, Yi Lu, Mengxin Yin, Chao Wang, Wei Wu, Jinhui Li, Wenqing Wu, Lianxin Hu, Yun Zhao and Lei Zhang. Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal. Journal of Biological Chemistry. 2016, 291:7926-7937. Chao Wang, Meng-Xin Yin, Wei Wu, Liang Dong, Shimin Wang, Yi Lu, Jinjin Xu, Wenqing Wu, Sheng Li, and Yun Zhao and Lei Zhang. Taiman acts as a co-activator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration. Cell Discovery. 2016, 2:16006. Lianxin Hu, Jiajun Xu, Meng-Xin Yin, Liguo Zhang, Yi Lu, Wenqing Wu, Zhaoyu Xu, Margaret S. Ho, Guanjun Gao, Yun Zhao and Lei Zhang. Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded. Cell Discovery. 2016, 2:15047. Hui Han, Jialin Fan, Yue Xiong, Wenqing Wu, Yi Lu, Lei Zhang and Yun Zhao*. Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription. Scientific Reports. 2016, 6:18937. (*Corresponding author) Hui Wang, Zaijun Ma, Kongyan Niu, Yi Xiao, Xiaofen Wu, Chenyu Pan, Yun Zhao, Kai Wang, Yaoyang Zhang and Nan Liu. Antagonistic roles between Nibbler and Hen1 modulate piRNA 3' ends in Drosophila. Development. 2016, 143(3):530-539. Chunying Liu, Yue Xiong, Jing Feng, Lei Zhang and Yun Zhao*. Sqh is involved in the regulation of Ci stability in Hh signaling pathway. Journal of Molecular Cell Biology. 2015, 7:584-587. (*Corresponding author) Liang Dong, Jinhui Li, Hongling Huang, Meng-Xin Yin, Jinjin Xu, Peixue Li, Yi Lu, Wenqing Wu, Hang Yang, Yun Zhao and Lei Zhang. Growth suppressor lingerer regulates bantam microRNA to restrict organ size. Journal of Molecular Cell Biology. 2015, 7(5):415-428. Qian Hao, Shi Jiao, Zhubing Shi, Chuanchuan Li, Xia Meng, Zhen Zhang, Yanyan Wang, Xiaomin Song, Wenjia Wang, Rongguang Zhang, Yun Zhao, Catherine CL Wong and Zhaocai Zhou. A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO Journal. 2015, 34(23):2903-2920. Zhao Zhang, Yanyan Wang, Chuanchuan Li, Zhubing Shi, Qian Hao, Wenjia Wang, Xiaomin Song, Yun Zhao, Shi Jiao and Zhaocai Zhou. The transitional endoplasmic reticulum ATPase p97 regulates the alternative nuclear factor NF-κB signaling via partial degradation of the NF-κB subunit p100. Journal of Biological Chemistry. 2015, 290(32):19558-19568. Lin Fu, Xiangdong Lv, Yue Xiaong and Yun Zhao*. Investigation of protein-protein interactions and conformational changes in Hedgehog signaling pathway by FRET. Methods in Molecular Biology, Hedgehog Signaling Protocols (Second Edition, Springer Science). 2015, 1322:61-70. (*Corresponding author) Zizhang Zhou, Xia Yao, Shuang Li, Yue Xiong, Xiaohua Dong, Yun Zhao#, Jin Jiang# and Qing Zhang#. Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling. Developmental Cell. 2015, 34(1):58-72. (#Co-senior author)

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