张永莲 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

1935年2月20日生于上海市，九三学社社员。1957年9月毕业于上海复旦大学化学系。1957年至今在中国科学院上海生化细胞所进行科研(研究实习员，助理研究员，副研究员，研究员，科学院院士)。从事放射生物学、激素对基因转录调控，近十年来进行精子在附睾中成熟的分子机制研究。1983-1999年间在英国ICRF、美国Chicago大学、Wisconsin大学(Madison)、North Carolina大学、荷兰ERUSMUS大学、澳大利亚Sydney大学等进行合作科研。从1993年至今，先后获得国家自然科学三等奖和二等奖、中科院自然科学一等奖、第二届科技十大女杰、上海市自然科学一等奖和科技功臣和何梁何利生命科学奖等

研究领域

主要从事雄激素对真核基因转录调控机制研究和睾丸生精过程中及附睾对精子成熟过程中的基因表达程序的调控，现集中在附睾功能基因组研究

近期论文

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P. Li, H. C. Chan, B. He, S. C. So, Y. W. Chung, Q. Shang, Y. D. Zhang, and Y. L. Zhang. 2001. An antimicrobial peptide gene found in the male reproductive system of rats. Science. 291(5509): 1783-1785. Q. Liu, K. G. Hamil, P. Sivashanmugam, G. Grossman, R. Soundararajan, A. J. Rao, R. T. Richardson, Y. L. Zhang, M. G. O’Rand, P. Petrusz, F. S. French, and S. H. Hall. 2001. Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human. Endocrinology. 142(10): 4529-4539. Y. X. Hu, J. Y. Guo, L. Shen, Y. Chen, Z. C. Zhang, and Y. L. Zhang. 2002. Get effective polyclonal antisera in one month. Cell Res. 12(2): 157-160. K. G. Hamil, Q. Liu, P. Sivashanmugam, S. Yenugu, R. Soundararajan, G. Grossman, R. T. Richardson, Y. L. Zhang, M. G. O’Rand, P. Petrusz, F. S. French, and S. H. Hall. 2002. Cystatin 11: a new member of the cystatin type 2 family. Endocrinology. 143(7): 2787-2796. Y. Hu, Z. Zhou, C. Xu, Q. Shang, Y. D. Zhang, and Y. L. Zhang. 2003. Androgen down-regulated and region-specific expression of germ cell nuclear factor in mouse epididymis. Endocrinology. 144(4): 1612-1619. C. X. Zhou, Y. L. Zhang, L. Xiao, M. Zheng, K. M. Leung, M. Y. Chan, P. S. Lo, L. L. Tsang, H. Y. Wong, L. S. Ho, Y. W. Chung, and H. C. Chan. 2004. An epididymis-specific beta-defensin is important for the initiation of sperm maturation. Nat Cell Biol. 6(5): 458-464. J. S. Zhang, Q. Liu, Y. M. Li, S. H. Hall, F. S. French, and Y. L. Zhang. 2006. Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray. Mol Cell Endocrinol. 250(1-2): 169-177. H. X. Yuan, A. H. Liu, L. Zhang, H. Zhou, Y. Wang, H. Zhang, G. Wang, R. Zeng, Y. L. Zhang, and Z. J. Chen. 2006. Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. J Proteome Res. 5(2): 299-307. H. Diao, C. Y. Guo, D. H. Lin, and Y. L. Zhang. 2007. Intein-mediated expression is an effective approach in the study of beta-defensins. Biochem Biophys Res Commun. 357(4): 840-846. C. F. Zhu, Q. Liu, L. Zhang, H. X. Yuan, W. Zhen, J. S. Zhang, Z. J. Chen, S. H. Hall, F. S. French, and Y. L. Zhang. 2007. RNase9, an androgen-dependent member of the RNase A family, is specifically expressed in the rat epididymis. Biol Reprod. 76(1): 63-73. J. Y. Li, H. Y. Wang, J. Liu, Q. Liu, J. S. Zhang, F. C. Wan, F. J. Liu, S. H. Jin, and Y. L. Zhang. 2008. Transcriptome analysis of a cDNA library from adult human epididymis. DNA Res. 15(3): 115-122. Y. C. Zhou, M. Zheng, Q. X. Shi, L. Zhang, W. Zhen, W. Y. Chen, and Y. L. Zhang. 2008. An epididymis-specific secretory protein HongrES1 critically regulates sperm capacitation and male fertility. PLoS One. 3(12): e4106. W. Zhen, P. Li, B. He, J. Y. Guo, and Y. L. Zhang. 2009. The novel epididymis-specific beta-galactosidase-like gene Glb1l4 is essential in epididymal development and sperm maturation in rats. Biol Reprod. 80(4): 696-706. D. M. Cao, Y. Li, R. Yang, Y. Wang, Y. C. Zhou, H. Diao, Y. Zhao, Y. L. Zhang, and J. Lu. 2010. Lipopolysaccharide-induced epididymitis disrupts epididymal beta-defensin expression and inhibits sperm motility in rats. Biol Reprod. 83(6): 1064-1070. S. G. Hu, G. X. Yao, X. J. Guan, Z. M. Ni, W. B. Ma, E. M. Wilson, F. S. French, Q. Liu, and Y. L. Zhang. 2010. Research resource: Genome-wide mapping of in vivo androgen receptor binding sites in mouse epididymis. Mol Endocrinol. 24(12): 2392-2405. Y. Zhao, H. Diao, Z. M. Ni, S. G. Hu, H. G. Yu, and Y. L. Zhang. 2011. The epididymis-specific antimicrobial peptide beta-defensin 15 is required for sperm motility and male fertility in the rat (Rattus norvegicus). Cell Mol Life Sci. 68(4): 697-708. C. M. Wang, C. Y. Huang, Y. H. Gu, Y. C. Zhou, Z. M. Zhu, and Y. L. Zhang. 2011. Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system. Glycobiology. 21(2): 225-234. Y. Chen, C. Chu, Y. C. Zhou, Y. F. Ru, H. R. Chen, F. Chen, Q. J. He, Y. L. Zhang, L. L. Zhang and J. L. Shi. 2011. Reversible pore-structure evolution in hollow silica nanocapsules: large pores for siRNA delivery and nanoparticle collecting. Small. 7(20): p. 2935-44. M. J. Ni, Z. H. Hu, Q. Liu, M. F. Liu, M. H. Lu, J. S. Zhang, L. Zhang and Y. L. Zhang. 2011. Identification and characterization of a novel non-coding RNA involved in sperm maturation. PLoS One. 6(10): e26053. Y. L. Zhang, J. S. Zhang, Y. C. Zhou, Y. Zhao and M. J. Ni. 2011. Identification of microRNAs and application of RNA interference for gene targeting in vivo in the rat epididymis. J Androl. 32(6): 587-91.