张荣光 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

1977年毕业于中国科技大学，1985-1988年美国芝加哥大学(Fellow, International Union against (Cancer, Geneva)，1988-1990年在美国耶鲁大学生物化学与分子生物学系作博士后研究工作，1990-2009年在美国阿贡国家实验室（ANL）先后为助理研究员、副研究员、研究员（Scientist），并相继担任生物部的结构生物学研究中心（SBC）资深研究员、美国中西部结构基因组学研究中心蛋白质晶体学部负责人、美国传染病结构基因中心晶体结构测定负责人。2009年回国，任中国科学院生物物理研究所研究员，中科院上海生化及细胞所研究员，从事结构生物学研究，并作为蛋白质科学研究上海设施建设副总工程师，参与上海光源生物大分子5线6站的建设。在Nature、Science 和 Cell 等国际著名学术刊物上发表SCI论文100余篇；作为第一作者，向蛋白质数据库(PDB)提交了200余个新的（氨基酸序列同源性低于30%）蛋白质晶体结构。

研究领域

同步辐射结构生物学方法与技术，神经干细胞不对称分裂过程的结构与功能研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Song, X., Yang, J, Hirbawi, J., Ye, S., Perera, H. D., Goksoy, E., Dwivedi, P., Plow, E.F., Zhang, RG*., and Qin, J*. A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Research. doi: 10.1038/cr.2012.97. (Epub ahead of print) Liu, Y., Zhu, Y., Ye, S., and Zhang, RG. Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation. Protein & Cell, 2012, 3:434-440. OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G., and Liu, Z. J, Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 2012, 36(6): 1073-1086. Kim Y, Joachimiak G, Ye Z, Binkowski TA, Zhang RG, Gornicki P, Callahan SM, Hess WR, Haselkorn R, Joachimiak A. Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria. Proc Natl Acad Sci U S A. 2011, 108:10109-14. Pardee KI, Xu X, Reinking J, Schuetz A, Dong A, Liu S, Zhang RG, Tiefenbach J, Lajoie G, Plotnikov AN, Botchkarev A, Krause HM, Edwards A. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS Biol. 2009, 7:e43. X He, J Zhou, M Bartlam, RG Zhang, J Ma, Z Lou, X Li, J Li, A Joachimiak, Z Zeng, R Ge, Z Rao & Y Liu. Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature, 2008, 454(7208): 1123-1126 VV Lunin, E Dobrovetsky, G Khutoreskaya, RG Zhang, A Joachimiak, DA Doyle, A Bochkarev, ME Maguire, AM Edwards & CM Koth. Crystal structure of the CorA Mg2+ transporter. Nature, 2006, 440 (7085): 833-837 M Shimaoka, T Xiao, JH Liu, YT Yang, YC Dong, CD Jun, A McCormack, RG Zhang, A Joachimiak, J Takagi, JH Wang & T Springer. Structures of the α LI domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell, 2003, 112: 99-111 JP Xiong, S Thilo, RG Zhang, A Joachimiak, SL Goodman & MA Arnaout. Crystal structure of integrin aVb3 in complex with an Arg-Gly-Asp ligand. Science, 2002, 296: 151-155 RG Zhang, T Pappas, J Brace, P Miller, T Oulmassov, J Molyneaux, J Anderson, J Bashkin, S Winans & A Joachimiak. Structure of a bacterial Quorum-Sensing Transcription factor Complexed with Pheromone and DNA. Nature, 2002, 417: 971-974 Xiong JP, Stehle T, Diefenbach B, Zhang RG, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science. 2001, 294:339-45. Z Otwinowski, RW Schevitz, RG Zhang, CL Lawson, RQ Marmorstein, A Joachimiak, B Luisi, & PB Sigler. Crystal structure of the Trp operator/repressor complex at atomic resolution. Nature, 1988, 335: 321-329 RG Zhang, A Joachimiak, CL Lawson, RW Schevitz, Z Otwinowski & PB Sigler. The crystal structure of the Trp aporepressor at 1.8 Å, showing how tryptophan enhances DNA affinity. Nature, 1987, 327: 591-597