曾艺 - 中国科学院上海生物化学与细胞生物研究所 -

研究领域

1) 发现各器官中成体干细胞的身份属性，包括乳腺、卵巢、血管、胰腺等； 2) 通过对比各成体干细胞，阐明干细胞“干性”的分子组成； 3) 发现成体干细胞新的微环境因子，阐明其调控干细胞的分子机理； 4) 研究干细胞关键调控分子在再生医学、癌症治疗中的调控变化

近期论文

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Yu QC, Verheyen EM,Zeng YA*. Mammary Development and Breast Cancer: A Wnt Perspective. Cancers. Jul 13;8(7).pii: E65. doi: 10.3390/cancers8070065. (2016) Yu QC, Song W, Wang D, Zeng YA*. Identification of blood vascular endothelial stem cells by the expression of protein C receptor. Cell Research. Jul 1. doi: 10.1038/cr.2016.85. (2016) Zeng L+, Cai C+, Li S, Yu QC, Wang W, Li Y, Chen J, Zhu X*, Zeng YA*. Essential roles of Cyclin Y-like 1 and Cyclin Y in dividing Wnt-responsive mammary stem/progenitor cells. PLOS Genetics. May 20;12(5):e1006055 (2016) WANGD+, Zeng YA*. Identification of Multipotent Mammary Stem Cells by Protein C Receptor Expression. Nature. Jan 1;517(7532):81-4 (2015) Cai C, Yu QC, Jiang W, Liu W, Song W, Yu H, Zhang L, Yang Y, Zeng YA*. R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal. Genes Dev. Sep 26;28: 2205–2218 (2014) Harburg G, Compton J, Liu W, Iwai N, Zada S, Marlow R, Strickland P, Zeng YA, Hinck L. SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling. Stem Cell Reports. Sep 9;3(3):385-93 (2014) Jan TA, Chai R, Sayyid ZN, van Amerongen R, Xia A, Wang T, Sinkkonen ST, Zeng YA, Levin JR, Heller S, Nusse R, Cheng AG. Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development. Mar;140(6):1196-206 (2013) Zeng YA*. Beyond nutrients and bonding: p63-positive progenitors in breast milk. Cell Cycle. Feb 15;10(4):579-8 (2011) Zeng YA and Nusse R*. Wnt proteins serve as self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell. Jun 4;6(6):568-77 (2010) Minear S, Leucht P, Jiang J, Liu B, Zeng A, Fuerer C, Nusse R, and Helms JA. Wnt proteins promote bone regeneration. Science Translational Medicine. Apr; 28;2(29):29ra30 (2010) Nusse R, Fuerer C, Ching W, Harnish K, Logan C, Zeng A, Ten Berge D, Kalani Y. Wnt Signaling and Stem Cell Control. Cold Spring HarbSymp Quant Biol. ;73:59-66 (2008) Zeng YA+, Rahnama M+, Wang S, Lee W, Verheyen EM*. Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding. PLoS ONE. Dec; 3(12):e3893 (2008) Zeng YA+, Rahnama M+, Wang, Sosu-Sedzorme W, Verheyen EM*. Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation.” Development. Jun; 134(11):2061-71 (2007) Zeng YA and Verheyen EM*. Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development.Development. Jun; 131(12):2911-20 (2004)