曾嵘 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

1995年毕业于湖南师范大学生物系；2000年毕业于中科院上海生物化学研究所，获生物化学与分子生物学博士学位；2000年-至今在中国科学院上海生命科学研究院生物化学与细胞生物学研究所蛋白质组研究分析中心工作，现为中心执行主任。2004年获得国家“杰出青年”基金，2005年获得中国青年女科学家奖，2005-2008年为国际人类蛋白质组组织(HUPO)理事会委员。2005年1月起担任Proteomics编委。2006年起担任Molecular and Cell Proteomics 编委。

研究领域

细胞内的蛋白质的表达，修饰，空间位置和相互作用是随时间，空间和环境因素动态变化的，因此用静态的或单一条件来进行研究显然不符合生命的动态性特征。更重要的是，蛋白质在各个层次上的变化可以相互影响，进而最终影响蛋白质或蛋白质群的功能。这种蛋白质多层次的变化总称为蛋白质动态行为。可以说，蛋白质的动态行为是生命复杂性，动态性和整体性的分子基础。研究如此复杂的蛋白质动态行为首先需要高通量，定量化和整体水平的研究技术

近期论文

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Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao S, Zhao GP. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 2010, 327:1004-7. Deng WJ, Nie S, Dai J, Wu JR, Zeng R*. Proteome, phosphoproteome and hydroxyproteome of liver mitochondria in diabetic rats at early pathogenic stages. Mol Cell Proteomics. 2010, 9:100-16. Wu YB, Dai J, Yang XL, Li SJ, Zhao SL, Tang JS, Zheng GY, Li YX, Wu JR, Zeng R*. Concurrent quantification of proteome and phosphoproteome to reveal system-wide association of protein phosphorylation and gene expression. Mol Cell Proteomics. 2009, 8:2809-26. Li H, Xing X, Ding G, Li Q,Wang C, Xie L, Zeng R*, Li Y. SysPTM - a systematic resource for proteomic research of post-translational modifications. Mol Cell Proteomics. 2009. 8:1839-49. Dai J, Wang LS, Wu YB, Sheng QH, Wu JR, Shieh CH, Zeng R*. Fully Automatic Separation and Identification of Phosphopeptides by Continuous pH-Gradient Anion Exchange Online Coupled with Reversed-Phase Liquid Chromatography Mass Spectrometry. J Proteome Res. 2009, 8:133-41. Li SJ, Peng M, Li H, Liu BS, Wang C, Wu JR, Li YX, Zeng R*. Sys-Body Fluid: a systematical database for human body fluid proteome research. Nucl. Acids Res. 2009, 37:D907-12. Ning ZB, Li QR, Dai J, Li RX, Shieh CH, Zeng R*. Fractionation of complex protein mixture by virtual three-dimensional liquid chromatography based on combined pH and salt steps. J Proteome Res. 2008, 7:4525-37. Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R*. Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry. J Proteome Res. 2007, 6: 250-62. Sheng QH, Wang LS, Dai J, Jiang XS, Li RX, Ma DJ, Li YX, Zeng R*, Wu JR. Comparison of a proteomic approach with a microarray-based approach to detect exons in the mouse genome. Nat Genet. 2006, 38:1223-4. Dai J, Shieh CH, Sheng QH, Zhou H, Zeng R*. Proteomic analysis with integrated multiple dimensional liquid chromatography/mass spectrometry based on elution of ion exchange column using pH steps. Anal Chem. 2005, 77:5793-9. Tu CJ, Dai J, Li SJ, Sheng QH, Deng WJ, Xia QC, Zeng R*. High-sensitivity analysis of human plasma proteome by immobilized isoelectric focusing fractionation coupled to mass spectrometry identification. J Proteome Res. 2005, 4:1265-73. Li Z, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Regulation of PTEN by Rho small GTPases. Nat Cell Biol. 2005, 7:399-404. Li C, Tan YX, Zhou H, Ding SJ, Li SJ, Ma DJ, Man XB, Hong Y, Zhang L, Li L, Xia QC, Wu JR, Wang HY, Zeng R*. Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers. Proteomics. 2005, 5:1125-39. Jiang XS, Tang LY, Dai J, Zhou H, Li SJ, Xia QC, Wu JR, Zeng R*. Quantitative analysis of severe acute respiratory syndrome (SARS)-associated coronavirus-infected cells using proteomic approaches: implications for cellular responses to virus infection. Mol Cell Proteomics. 2005, 4:902-13. Jiang XS, Dai J, Sheng QH, Zhang L, Xia QC, Wu JR, Zeng R*. A comparative proteomic strategy for subcellular proteome research: ICAT approach coupled with bioinformatics prediction to ascertain rat liver mitochondrial proteins and indication of mitochondrial localization for catalase. Mol Cell Proteomics. 2005, 4:12-34.