杨巍维 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

2001年获武汉大学学士学位，2007年获中科院上海生科院健康科学研究所博士学位，2008至2013年在美国安德森癌症中心（MD Anderson Cancer Center）做博士后研究，并成为奥德赛学者（Odyssey Fellow）。2013年8月起担任中科院生物化学与细胞生物学研究所研究员，研究组长，博士生导师

研究领域

1、癌症等重大疾病的代谢重编程机制 2、代谢小分子新功能 3、肿瘤微环境与肿瘤细胞代谢的交互调控

近期论文

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Wang X, Liu R, Zhu W, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G*, Yang W*. α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development. Molecular Cell, 2019 Aug 22;DOI:https://doi.org/10.1016/j.molcel.2019.07.007 Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G, Yang W*. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature; 2019 Jul; 571(7763):127-131. Liu R, Li W, Tao B, Wang X, Yang Z, Zhang Y, Wang C, Liu R, Gao H, Liang J, Yang W*. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nat Commun, 2019 Mar 1; 10(1):991. Jin G, Zhang Y, Cong W, Wu X, Wang X, Wu S, Wang S, Zhou W, Yuan S, Gao H, Yu G, Yang W*. Phosphoglucomutase 1 Inhibits Hepatocellular Carcinoma Progression by Regulating Glucose Trafficking. PLOS Biol, 2018, 16(10): e2006483. Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G, Liang J, Yang W*. Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis. Mol Cell, 2018 July; 71:1-15 Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W and Yang W*. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res, 2017 Mar; 27(3):329-351. Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W*, Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun, 2016 Aug 3; 7:12431. Yang W, Zheng Y, Xia Y, Ji H, Cote G, Aldape K, Chen X, Lu Z*. ERK1/2-dependent nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol, 2013 Jan; 15(1):124. Yang W, Xia Y, Zheng Y, Bu W, Yung W, Cote G, Aldape K, Li Y, Verma I, Chiao P, Lu Z*. EGFR-induced NF-kB activation upregulates PKM2 expression and promotes the Warburg effect. Mol Cell, 2012 Dec 14; 48(5):771-84. Yang W, Xia Y, Hawke D, Li X, Liang J., Xing D, Aldape K, Hunter T, Yung W, Lu Z*. PKM2 phosphorylates Histone H3 and promotes gene transcription and tumorigenesis. Cell, 2012 Aug 17; 150(4):685-96. Yang W, Xia Y, Ji H, Zheng Y., Liang J., Huang W, Gao X, Aldape K, and Lu Z*. Nuclear PKM2 regulates beta-catenin transactivation upon EGF stimulation. Nature, 2011 Dec 1; 480(7375):118-22.