孙丽明 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

2014-至今，研究员，中科院上海生物化学与细胞生物学研究所 2009-2014，博士后，美国西南医学中心/北京生命科学研究所 2005-2009，博士，北京生命科学研究所 2001-2005，学士，北京师范大学

研究领域

细胞坏死的分子基础与相关疾病机理

近期论文

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Zhang J, Yang Y, Zhou S, He X, Cao X, Wu C, Hu H, Qin J, Wei G, Wang H, Liu S* and Sun L*. Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling. Cell Death & Differentiation, 2019, DOI :10.1038/s41418-019-0441-3. Zhang J, Yang Y, He W, and Sun L*. Necrosome core machinery: MLKL. Cellular and Molecular Life Sciences, 2016,73, 2153-2163. (*Corresponding author) Sun L.* and Wang X. A new kind of cell suicide: mechanisms and functions of programmed necrosis. Trends in biochemical sciences, 2014, 39, 587-593 (*Corresponding author) Su L, Quade B, Wang H, Sun L, Wang X, and Rizo J. (2014) A Plug Release Mechanism for Membrane Permeation by MLKL. Structure, 2014, 22(10): 1489-1500 Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS, and Wang X. Mixed Lineage Kinase Domain-like protein MLKL Causes Necrotic Membrane Disruption Upon Phosphorylation by RIP3. Mol Cell, 2014, 54, 133-146. *Cover story. Story of this work was selected by Faculty of 1000 Biology Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, and Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell, 2012, 148, 213-227. *Research of this work was highlighted in Cell, Nature Reviews Molecular Cell Biology, and Chem. & Eng. News. Story of this work was selected by Faculty of 1000 Biology. Liao D, Sun L, Liu W, He S, Wang X, and Lei X. Necrosulfonamide Inhibits Necroptosis by Selectively Targeting the Mixed Lineage Kinase Domain-like Protein. Med. Chem. Commun., 2014, 5, 333-337. Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S, Shao F. Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature, 2013, 501, 242-6. Hildebrand JM, Sun L, and Silke J. An appointment with death,生死有时: 2013 Cold Spring Harbor Asia meeting ‘Mechanisms and Functions of Non- Apoptotic Cell Death’. Cell Death Differ, 2013, 20, 1593-4. Sun L, Wang H, Hu J, Han J, Matsunami H, and Luo M. Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. Proc Natl Acad Sci U S A, 2009, 106, 2041-2046. Luo M, Sun L, and Hu J. Neural detection of gases--carbon dioxide, oxygen--in vertebrates and invertebrates. Curr Opin Neurobiol, 2009, 19, 354-361.