刘默芳 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

分别于1991年、1994年在华东理工大学获学士、硕士学位，2000年在中科院上海生物化学研究所获博士学位。分别于2000 -2005年、2005-2006年在美国国家健康研究院癌症研究所 (National Cancer Institute, NIH)博士后研究、约翰霍浦金斯医学院遗传和分子生物学系任研究助理。2006-至今，中科院上海生化细胞所，先后担任co-PI、RNA研究技术平台主任、研究组长。入选2013年国家杰出青年科学基金。担任Journal of Biological Chemistry、Biology of Reproduction等期刊编委、中国生物化学与分子生物学会理事会常务理事及RNA专业委员会副主任

研究领域

实验室的主要兴趣在于了解非编码RNA的功能和作用机制，主要开展了miRNA在癌症发生中的功能机制、piRNA在哺乳动物精子发生中的功能机制等两方面的研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Li F, Yuan P, Rao M, Jin CH, Tang W, Rong YF, Hu YP, Zhang F, Wei T, Yin Q, Liang T, Wu L, Li J, Li D, Liu Y, Lou W, Zhao S*, Liu MF*. piRNA-independent Function of PIWIL1 as a Co-activator for Anaphase Promoting Complex/Cyclosome to Drive Pancreatic Cancer Metastasis. Nat CellBiol, 2020, March 16. https://doi.org/10.1038/s41556-020-0486-z. Wang X, Li ZT, Yan Y, Lin P, Tang W, Hasler D, Meduri R, Li Y, Hua MM, Qi HT, Lin DH, Shi HJ, Hui J, Li J, Li D, Yang JH, Lin J, Meister G, Fischer U, Liu MF*. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Mol Cell, 2020, 77:999-1013. Published as a Cover story. Dai P, Wang X, Gou LT, Li ZT, Wen Z, Chen ZG, Hua MM, Zhong A, Wang L, Su H, Wan H, Qian K, Liao L, Li J, Tian B, Li D, Fu XD, Shi HJ*, Zhou Y*, Liu MF*. Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis. Cell, 2019, 179:1566-1581. Highlighted by Nat Rev Mol Cell Biol；Recommended by F1000Prime；入选2019年中科院科技创新亮点成果. Dai P, Wang X, Liu MF*. A dual role of the PIWI/piRNA machinery in regulating mRNAs during mouse spermiogenesis. Sci China Life Sci, 2020, 63: 447-449. Wang X, Kang JY, Wei L, Yang X, Sun H, Yang S, Lu L, Yan M, Bai M, Chen Y, Long J, Li N, Li D, Huang J, Lei M, Shao Z, Yuan W, Zuo E, Lu K*, Liu MF*, Li J*. PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis. Development. 2019,146: dev175547. Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ*, Liu MF*. Ubiquitination-deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell, 2017,169:1090-1104. Highlighted by Nat Rev Urol and Reprod Biol; 入选2017年中国生命科学十大进展、中科院科技创新亮点成果. Zhang LF, Jiang S*, Liu MF*. MicroRNA regulation and analytical methods in cancer cell metabolism. Cell Mol Life Sci, 2017, 74:2929-2941. Yuan P, He XH, Rong YF, Cao J, Li Y, Hu Y, Liu Y, Li D, Lou W*, Liu MF*. KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis. Cancer Res, 2017, 77:100-111. He XH, Zhu W, Yuan P, Jiang S, Li D, Zhang HW, MF Liu*. miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells. Oncogene, 2016, 35:6015-6025. Zhang LF, Lou JT, Lu MH, Gao C, Zhao S, Li B, Liang S, Li Y, Li D, Liu MF*.Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma. EMBO J, 2015, 34:2671-2685. Zhang P, Kang JY, Gou LT, Wang J, Xue Y, Skogerboe G, Dai P, Huang DW, Chen R, Fu XD*, Liu MF*, He S*. MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. Cell Res, 2015, 25:193-207. Wang L, Zhang LF, Wu J, Xu SJ, Xu YY, Li D, Lou JT*, Liu MF*. IL-1β-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis. Cancer Res, 2014, 74:4720-4730. Gou LT, Dai P, Liu MF*. Small non-coding RNAs and male Infertility. WIREs RNA, 2014, 5:733-745. Gou LT, Dai P, Yang JH, Xue Y, Hu YP, Zhou Y, Kang JY, Wang X, Li H, Hua MM, Zhao S, Hu SD, Wu LG, Shi HJ, Li Y, Fu XD, Qu LH, Wang ED, Liu MF*. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res, 2014, 24:680-700. Published as a Cover story, highlighted by Cell Res; 入选中国科协“生命科学与基础医学10篇优秀论文”. Hu S, Zhu W, Zhang LF, Pei M, Liu MF*. MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer. Cell Res, 2014, 24:254-257. Zhao S, Gou LT, Zhang M, Zu LD, Hua MM, Hua Y, Shi HJ, Li Y, Li JS, Li DS, Wang ED*, Liu MF*. piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev Cell, 2013, 24:13-25. Highlighted by Dev Cell and Asian J Androl. Qiao M, Zu LD, He XH, Shen RL, Wang QC, Liu MF*. Onconase down-regulates microRNA expression through targeting microRNA precursors. Cell Res, 2012, 22:1199-202. Jiang S, Zhang LF, Zhang HW, Hu S, Lu MH, Liang S, Li B, Li Y, Li D, Wang ED, Liu MF*. A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase2 in breast cancer cells. EMBO J, 2012, 31:1985-1998. Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF*, Wang ED. MicroRNA-155 functions as an oncomiR in breast cancer by targeting the suppressor of cytokine signaling-1 gene. Cancer Res, 2010, 70: 3119-3127. Zhao S, Liu MF*. Mechanisms of miRNA-mediated gene regulation. Sci China C Life Sci, 2009, 52:1111-1116.