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个人简介

1993年7月毕业于江西农业大学畜牧兽医系,获理学学士学位;1996年7月毕业于扬州大学畜牧兽医学院,获理学硕士学位;2002年7月毕业于中国科学院动物研究所,获理学博士学位;2002年8月至2007年7月在美国洛克菲勒大学从事博士后研究;2007年8月起任中科院上海生科院生物化学与细胞生物学研究所研究员,研究组长。2012年获“杰出青年基金”支持,2013年入选“中青年科技创新领军人才”

研究领域

干细胞与胚胎发育

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Li Y & Li J*. Technical advances contribute to the study of genome imprinting. PLOS Genet 2019. (Invited review) Wang L & Li J*. ‘Artificial spermatid’-mediated genome editing. Biol Reprod 2019. (Invited review) Wang J#, Chen J#, Wu G#, Zhang H#, Du X#, Chen S, Zhang L, Wang K, Fan J, Gao S, Wu X, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y*, Li J*, Yun C* & Cheng H*. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes & Dev 2019 Mar 10. DOI: 10.1101/gad.322602.118 Song W, Wang R, Jiang W, Yin Q, Peng G, Yang R, Yu QC, Chen J, Li J, Cheung TH, Jing N & Zeng Y. Hormones induce the formation of luminal-derived basal cells in the mammary gland. Cell Res 2019 Jan 10. Li J* & Gao C*. Preface to the special topic on genome editing research in China. Nat Sci Rev 2019 Jiang Jing, Yan M, Li D & Li J*. Genome tagging project: tag every protein in mouse through “artificial spermatids”. Nat Sci Rev 2019 Lander E, Baylis F, Zhang F, Charpentier E, Berg P, Bourgain C, Friedrich B, Joung JK, Li J, Liu D, Naldini L, Nie JB, Qiu R, Schoene-Seifert B, Shao F, Terry S, Wei W & Winnacker EL. Adopt a moratorium on heritable genome editing. Nature 567(7747)(2019): 165-168. Wang Haoyi, Li J, Li W, Gao C & Wei W. CRISPR twins: China Academy responds. Nature 564(7736)(2018): 345. Li Qing, Li Y, Yang S, Huang S, Yan M, Ding Y, Tang W, Lou X, Yin Q, Sun Z, Lu L, Shi H, Wang H, Chen Y* & Li J*. CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development. Nat Cell Biol 20(11)(2018): 1315-1325. Epub 2018 Oct 01. Chen Yao, Zheng Y, Gao Y, Lin Z, Yang S, Wang T, Wang Q, Xie N, Hua R, Liu M, Sha J, Griswold MD, Li J*, Tang F* & Tong M*. Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis. Cell Res 28(9)(2018), 879-896. Epub 2018 Jul 30. Qu Chao, Yan M, Yang S, Wang L, Yin Q, Liu Y, Chen Y & Li J*. Haploid embryonic stem cells can be enriched and maintained by simple filtration. J Biol Chem 293 (14) (2018): 5230-5235. Li ZiYi, Huang M, Wang X, Zhu Y, Li J, Wong CCL & Fang Q. Nanoliter-scale oil-air-droplet chip-based single cell proteomic analysis. Anal Chem 90(8)(2018), 5430-5438. Epub 2018 Mar 27. Liu Wuqing, Li S, Zhang Y, Li J & Li Y. Efficient CRISPR-based genome editing using tandem guide RNAs and editable surrogate reporters. FEBS Open Bio 8(7)(2018), 1167-1175. Wang Xiukun & Li J*. An intermediate cell state allows rerouting of cell fate. J Biol Chem 292(46)(2017), 19133-19134. (Highlight). Wei Leixin, Wang X, Yang S, Yuan W* & Li J*. Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene-editing. J Genet Genomics 44(9)(2017), 461-463. Aug 12. Zheng Yi, Jongejan A, Mulder CL, Mastenbroek S, Repping S, Wang Y, Li J & Hamer G. Trivial role for NSMCE2 during in vitro proliferation and differentiation of male germline stem cells. Reproduction 154(3)(2017), 81-95. Li Haisen, Guo A, Xie Z, Tu W, Yu J, Wang H, Zhao J, Zhong C, Kang J, Li J, Huang S & Shen L. Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation. Sci Rep 7(1)(2017), 13222. Feng Su, Xing C, Shen T, Qiao Y, Wang R, Chen J, Liao J, Lu Z, Yang X, Abd-Allah SM, Li J, Jing N & Tang K. Abnormal paraventricular nucleus of hypothalamus and growth retardation associated with loss of nuclear receptor gene COUP-TFII. Sci Rep 7(1)(2017), 5282. Wang Yinghua, Ding Y & Li J*. CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Methods Mol Biol 1622(2017), 293-305. Zuo Erwei#, Cai Y-J#, Li K#, Wei Y#, Wang B-A#, Sun Y, Liu Z, Liu J, Hu X, Wei W, Huo X, Shi L, Tang C, Liang D, Wang Y, Nie Y-H, Zhang C-C, Yao X, Wang X, Zhou C, Ying W, Wang Q, Chen R-C, Shen Q, Xu G-L, Li J, Sun Q*, Xiong Z-Q* & Yang H*. One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. Cell Res 27(7)(2017), 933-945. Epub 2017 June 6.

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